I just want to be a quiet scholar

Chapter 453 Features
401 Lab.

Shen Qi showed some samples to Lao Yan: "I synthesized this. In theory, it is a medicine for treating immune diseases. After analysis, the ingredients are the same as Leluoxianfen, but the safety and toxicity of the medicine are the same. The physiology and drug metabolism properties need to be further verified through animal experiments."

"Can I see your route?" Lao Yan asked.

"Here." Shen Qi spread out a piece of paper on which Le Luoxianfen's road map was drawn.

The design of effective synthetic routes for complex organic molecules is one of the most difficult problems in organic chemistry. Route design is the first and most important step in the synthesis work.

In English materials, terms such as strategy and art are often seen in the description of organic synthesis route design, and organic synthesis route design has risen to the height of strategy and art.

The strategic route of Shen Qi’s version of Leluoxianfen started from the reaction of benzoate and amine, and ended in the metal-catalyzed coupling method to obtain Leluoxianfen with a relatively large steric hindrance. The total yield was 43%, and a total of 30-step route.

Lao Yan concentrated on studying Shen Qi's route design, and couldn't help but be overwhelmed: "The 30-step route can get a total yield of 43%, which is amazing."

Shen Qi felt a little regretful: "Indeed, there are too many routes. If you can control it within 20 steps, the total yield will be even more impressive. But there is no way, I am a copycat version of Le Luo Xian Fen, and it is impossible to follow the original strategy route. It is exactly the same as Eli Lilly, and I believe their route design must be simpler and the total yield higher.”

The strategic route design of organic synthesis is different from mathematics and physics calculations. Mathematics and physics have fixed formulas and theorems, while organic synthesis is more flexible.

Any synthetic route, as long as it can synthesize the desired compound, should be said to be reasonable.

However, there are very large differences between reasonable synthetic routes.The yield of each step of some synthetic routes is all higher, but the total yield is only less than 1%, because there are too many steps.

"Boss Shen, what do you need me to do?" Lao Yan habitually touched his pocket, his cigarettes were in his pocket.

Shen Qi reminded: "Hey, you're addicted to smoking again? It's been less than 30 minutes. Can you restrain yourself? You are a chemistry student. Don't you know that smoking in the laboratory is dangerous?"

"As soon as I entered the academic state, I wanted to smoke." Lao Yan still has professional ethics. He just touched the cigarette case and did not take it out.

"Condoclon, have you heard of it?" Shen Qi took out a bottle of medicine.

Lao Yan took the medicine bottle, opened the lid to look at the medicine inside, and looked at the instructions: "Condoclan, a Swiss medicine for treating anemia, this medicine is quite expensive."

Shen Qi gave the task: "This imported drug costs 1 yuan a bottle, old smoke, synthesize it."

Lao Yan asked in surprise, "Boss, are you kidding me?"

Shen Qi said seriously: "Do you think I'm joking?"

"Are you going to open a fake pharmaceutical factory?" Lao Yan wondered if he had been tricked into a black shop.

Shen Qi explained: "First, we only reverse-analyze and forward-synthesize. It's an experimental nature, and we don't open a pharmaceutical factory and don't sell it. Second, what we synthesize is not a counterfeit drug, at most it is a generic drug, and it will not enter the market. For research use only."

"Forward synthesis after reverse analysis, the imitation object is an extremely complex drug, which is almost challenging the limit of my academic ability." Lao Yan rubbed his hands solemnly, and said: "But for the establishment of the central smoking area, I accept this challenge."

"Okay, if you encounter any problems during the synthesis process, you can communicate with me." After arranging Lao Yan's tasks, Shen Qi went to the animal laboratory next door.

Before Lao Yan came to the center, Shen Qi had studied his past academic achievements, personal experience and other detailed information.

Lao Yan studied at Yan University College of Chemistry for undergraduate and postgraduate studies, and went to Stanford for a year as an exchange in the middle.

Although he doesn't have a Ph.D., Lao Yan has enough laboratory experience.

To Shen Qi's surprise, Lao Yan graduated with a master's degree at the age of 24 and is 28 years old this year. He has published as many as 15 chemical papers in four years, but he does not own a single chemical patent.

Many of the papers written by Lao Yan are wild and unconstrained, with grand wishes but difficult to implement.

Shen Qi felt that it wasn't that Lao Yan was a master but that Lao Yan was a man with ideas, imagination, and a bit of skin. From Lao Yan's homemade glove-shaped friction cigarette lighting material, he could see his character.

It doesn't matter whether Bo is a doctor or not if organic synthesis reaches a certain level. This experimental subject relies on imagination, observation, and logical deduction.Shen Qi thought that Lao Yan possessed these potentials, that's why he was hired.

"But this guy, Lao Yan, is really addicted to smoking." Shen Qi complained. Back then, Lao Yan's information stated "in good health and no bad habits." Two packs of cigarettes a day, is this still healthy?
Lao Tu, the administrator of the animal laboratory, said: "Many men who do scientific research smoke. I have stayed at Yanda for 20 years. Most of the men in science and engineering I met were not good at socializing and had no time to socialize. Science takes a lot of time. But people always need to relax. Drinking alcohol can hurt your mind, and a big drink also takes time, so there are many people who smoke. It’s good to smoke a cigarette for a few minutes and continue to study science after smoking.”

"I understand this, but I still advocate a healthy life and cultivate other interests and hobbies of scientific researchers." Most of the scientific researchers Shen Qi contacts are in this situation. Their social circles are small, and their social relationships are basically those around their majors except their parents and relatives. Colleagues and peers in the small circle.

Scientific researchers who devote themselves to learning and working on projects do not have much time to go to parties, go shopping, and go surfing. Their life trajectory is relatively monotonous, home-laboratory-home.

"Come on, Lao Tu." Shen Qi chatted with Lao Tu for a few words, and then entered the topic.

The theme is to inject Leluoxianfen into two female monkeys, Xiaohong and Xiaomei.

After the animals were anesthetized, they were injected with experimental drugs. This was basic practice. Shen Qi and Lao Tu worked together to get it done quickly.

Next, Shen Qi needs to conduct toxicology, pharmacokinetics, and drug metabolism tests on Xiaohong and Xiaomei on a regular basis. This process will last for several months, during which time some female mouse subjects will be added to obtain more sufficient experiments. data.

At five o'clock, Shen Qi drove to several courtyards to pick up Ouye and went home.

Ouye suddenly said: "Show me the 1017 baby names you think of."

Shen Qi: "In the glove box."

Ouye opened the glove box with great interest, saw a notebook, took it out and read it.

When a woman is three to four months pregnant, B-ultrasound can tell the sex of the fetus.

The country does not allow non-medical fetal sex identification, but Shen Qi and his wife must have a way to know the sex of the fetus in advance, if they want.

However, Shen Qi and Ouye decided to keep the suspense until the delivery in August, and they did not know the sex of the fetus in advance.

Looking at the list of baby names compiled by Shen Qi, Ouye was speechless.

The book says:
Boy, Shen differential, sedimentation, Shen number theory, Shen number fraction, Shen complex change, Shen change calculus...

Girl, heavy quantum, heavy atom, heavy proton, heavy neutron, heavy ion, heavy soliton...

Ouye completely understood the baby naming rules written by Shen Qi, so he just copied it from math books and physics books. No wonder he was able to copy out 1017 professional terms.

Although he understood, Ouye couldn't accept it.

"Shen Qi, can you be more serious!!!" Ouye roared, very emotional, and used three exclamation marks in succession.

"Honey, I'm serious!!!" Shen Qi used four exclamation marks, he wasn't joking, this was his real thought.

"Shen Qi, your uncle!" Ouye thumped the dashboard angrily, and she angrily scolded Shen Qi: "I'm a cheater, Shen scientist, you cheater!"

Shen Qi was still wronged: "Why did I cheat my baby? The baby name I chose is not good, is it too vulgar, or is the realm too low?"

"My colleague in the office next door gave birth to a boy named Liu Haoxuan. The baby girl downstairs in our house is named Zhang Zixuan." Ouye cited an actual case, and she said: "Husband, can we name our baby more mainstream?" ? Haoxuan, Zixuan, they sound pretty good."

Shen Qi has his theoretical basis: "Honey, you must believe in my professionalism and forward-looking vision. I have done mathematical statistics, and the Haoxuan and Zixuan you mentioned are the most frequent names for newborns today. , Haoxuan ranks first in male BB, and Zixuan ranks first in female BB. Haoxuan and Zixuan sound good now, but after a few years, the streets will be full of Mr. Haoxuan and Mrs. Zixuan, they are nothing special."

If you think about it, the frequency of Haoxuan and Zixuan is indeed too high. In a few years, there may be Haoxuan children 01~08 and Zixuan children 01~18 in the kindergarten. Parents of children will easily recognize them.Ouye is still insisting, but a little bit loose: "Then you name it with a branch of mathematics or a physical name, so it is distinctive?"

"It's really unique, but... super unorthodox, okay?" Ouye was speechless. If her child was named Shen Shulun, Shen Shufen or something, it would be fair to say that she would become a top student when she grows up. What if she was a student? Scum, that would be very embarrassing.

Shen Qi asked: "Honey, if you had to choose one from my name list, what would you choose? Of course, as the mother of the child, you have the right to overturn all my plans. Shen Haoxuan and Shen Zixuan sound good too. If you Adhere to Haoxuan and Zixuan's mainstream and popular plans, and I will respect your choice."

(End of this chapter)