I just want to be a quiet scholar

Chapter 473
After some conversation, Shen Qi was quite satisfied with Dr. Qu, and hoped that Dr. Qu could come to the center to develop and engage in the research of basic theoretical physics.

Dr. Qu is currently working at the Central South Institute of Mathematical Physics, Academy of Sciences. He promised Shen Qi that he would come to Yanda to report immediately after completing the formalities there.

After dealing with mathematics and physics, Shen Qi next cared about chemistry.

Regarding the benzazepine compound code-named C01B, Lao Yan had already completed a thesis and handed it over to Shen Qi.

The abstract of this paper is as follows:
"Study on the synthesis process of benzazepines, using benzazepines and nitrotrifluoromethanesulfonic acid as starting materials, through condensation, hydrolysis, nitration, substitution and other reactions, a new compound 4-oxidation-5- Phenyl-1-tetrahydro-3-methylene-4H-6-benzazepine.

After 10 steps of reaction, the target compound 4-oxo-5-phenyl-1-tetrahydro-3-methylene-4H-6-benzazepine was synthesized, and its structure was verified by H -NMR (proton nuclear magnetic resonance spectrum) and MS (mass spectrometry) confirmed that the total yield was 6%. "

The text of the thesis consists of two parts, the first part is "synthetic route", and the second part is "experimental part".

The synthetic route mainly talks about the synthetic strategy design of the target product C01B, citing some literatures as support to illustrate that such a strategic route design is reasonable.

The experimental part is subdivided into ten small sections from 2.1 to 2.10, which elaborate the specific experimental operation of the ten-step reaction in detail.

“2.6、采用2-二环己基-二苯基膦（0.27mol）在1，2-二甲氧基乙烷中，60摄氏度反应2h。在钯催化条件下，加入化学当量的叔丁醇钠……”

It has been refined to this extent, and any professional chemist can obtain the target product C01B by following the steps in the "Experimental Part".

Shen Qi saw that there were two authors of this paper, with Shen Qi in front and Yan Jun in the back.

Shen Qi revised the thesis, putting Yan Jun's name in the front and his own name in the back.

For the summary and text, Lao Yan wrote more rigorously, and Shen Qi had nothing to change.

This is a standard organic chemistry synthesis paper, which only describes the design of the synthetic route, the laboratory operation of each step reaction, the yield of each step and the total yield, and does not involve the content of pharmacology.

Toxicology, pharmacokinetics and other professional content need a lot of data support from animal experiments and clinical trials, and large-scale industrial production requires process chemistry teams to verify.

After all the above-mentioned things are completed, a drug can form the basic conditions for commercialization and have the possibility of being marketed.

Shen Qi positioned C01B as "a kind of chemical test product in the preliminary laboratory test stage". As for the practical use and scientific value of C01B, let's talk about it in the next paper.

Shen Qi and Lao Yan synthesized C10B in a 01-step reaction in the laboratory. This chemical name is 4-oxo-5-phenyl-1-tetrahydro-3-methylene- Shen Qi believes that 4H-6-benzazepine, a new type of test product, has the effect of smoking cessation. Of course, this needs further verification.

The total yield of 26.2% has the value of continuing research. After the paper is written, it should be sent out as soon as possible.

There are also so-called four major journals in the international chemical community, which are "Nature", "Science", "German Applied Chemistry" (ANGEWC), and "Journal of the American Chemical Society" (JACS).

"Nature" and "Science" are very real journals. They only give synthetic routes and do not give application value evaluation. Such chemical articles are difficult to be included.

Many of the chemical articles included in "Nature" and "Science" are not pure chemistry, but more like articles on pharmaceutical engineering or biochemistry.

This is very similar to the selection of the Nobel Prize in Chemistry in recent years. Many winners come from various interdisciplinary fields such as physical chemistry, medicinal chemistry, and biochemistry.

ANGEWC and JACS maintain relatively pure chemical properties, which can be seen from the IF value.

The IF value of "Nature" and "Science" is above 30 all year round, while ANGEWC and JACS hover between 10-15, and it is almost difficult to break through 15.

After careful consideration, Shen Qi asked Lao Yan to submit his thesis to JACS in the United States.

"It's so stupid that you voted for the top four for your first chemistry paper?" Lao Yan has published more than a dozen papers in his career, and the most important one was published in the "Chemical Perspectives" in the UK.

According to Shen Qi's grading system, if the four major chemical journals belong to the T0 level, then the level of "Chemical Perspectives" should be between T2 and T1.

"It's not me, but us." Shen Qi said, "Submit your manuscript, hurry up, send it out as soon as possible, and own the original intellectual property rights as soon as possible."

Lao Yan wrote down the synthesis steps of C01B in such detail that it can be regarded as teaching others to do experiments.

People copy it again according to this paper, and they can also get the target product with a comparable yield.

Therefore, it is necessary to send it out as soon as possible, and be the first to own the original intellectual property rights. In the future, others can quote it but not copy it in full, otherwise it will be academic plagiarism.

Mathematics, physics, chemistry, Shen Qi finished handling these tasks, and a day passed.

Ouye is waiting for delivery at home, and has not come to Yanda for work recently.

Shen Qi didn't need to pick up his wife from the hospital at five o'clock. He changed into sports clothes and sneakers, and went to the playground to do some exercise.

He hadn't made out with his wife for eight or nine months, had no lover outside, and didn't do any health care. How did Shen Qi get through this period of abstinence.

Exercise, work, distraction, sublimate inner desires, transform physical desires into spiritual satisfaction.

But this is very difficult to do, people have emotions and desires, and scientists are human too.

Shen Qi even had the idea of ​​using chemical drugs. There is a type of drug that can effectively suppress sexual desire. Some countries use this type of drug to punish sexual offenders with chemical castration.

Fortunately, Shen Qi survived. As a scientist with emotions and desires, his willpower is also strong enough.

Ouye's due date was August 8rd, and in the blink of an eye it was late July, and Shen Qi didn't go anywhere, so he stayed at home and worked in the academician's villa.

Ouye's parents also came to the capital and lived in Academician Shen's villa.

The villa is big enough to accommodate Shen Qi and his wife, Ouye's parents, and Cuiping.

The villa was specially designed by the state for Shen Qi. During this time, Shen Qi lived with Ouye's mother's family, and the four of them took care of a expectant mother.

Ouye Niang's family used to live in villas, and they are quite used to living in Academician Shen's villa.

Shen Qi wasn't used to it anymore, it would be more comfortable for the young couple to live alone in a house.

The nature of Lao Ou's work is not very busy. If he has work, he will go outside to work, and if he has no work, he will rest.

The mother-in-law, Lao Ye, is a busy person. She is in the capital, and every day she directs the important business of her real estate company remotely.

"Honey, don't call, okay, your daughter is about to give birth." Lao Ou complained about Lao Ye.

"Don't fight anymore, mute." Lao Ye is the head of the house, and Lao Ou usually obeys her command, but today she obeys Lao Ou's arrangement.

"Dad, Mom, let Xiao Yezi go to the hospital in a few days." Shen Qi said.

"Yes." Lao Ye gave birth to a child, she has experience.

Just as she was talking, Lao Ye's cell phone rang. She glanced at the incoming call and said, "This call must be answered. It's from the deputy mayor's secretary."

"Go outside to answer the phone, the mobile phone has radiation." Lao Ou knew that his wife had more than one mobile phone, and he was very upset.

"Okay, okay, it will be over soon." Lao Ye went to answer the phone outside the villa.

The division of labor in Ouye's family is exactly the opposite of that in Shen Qi's family. Ouye's mother runs a business and starts a company, while her father works in a public institution.

"Damn's company is so big, it's normal to have business." Shen Qi comforted Lao Ou.

"This woman knows how to make money if she loses her eyes on money. What does she want to be the richest woman?" Lao Ou quit smoking and drinking after he came to the capital. He set an example, but his wife still did her own way.

Lao Ou, you are awesome, my mother-in-law will come in later after calling, you have the guts to say the same... Shen Qi poured Lao Ou a cup of tea to calm him down.

"Money, how much money is earned is the end? There is no end to it. Your mother-in-law is very hard. I understand that she is busy with work and business day and night for this family. With such a big business, But one day she has to retire and be an old lady quietly. We are only Xiao Yezi, an only daughter. Is the daughter more important than the business? Of course, I understand how your mother-in-law feels. Accumulate more family wealth, so that Xiao Yezi can live comfortably in the second half of her life." Lao Ou loves and hates his wife, and he feels distressed and itchy and wants to condemn her.

Shen Qi said: "Dad, don't you have me here? I assure you, I can definitely make Xiao Yezi have no worries about food and clothing for the rest of his life. You two have worked hard all your life, so you should enjoy it by yourself."

"Father to son, mother to daughter, it's a matter of course. If our family fortune is not passed on to Xiao Yezi, who else can we give it to?" Old Ou said as a matter of course.

The situation of Ouye's family is very similar to that of Shen Qi's family, the only child who loves science and does not know how to do business but cannot avoid the fate of inheriting the family property.

"That's the truth, but Xiao Yezi can manage such a large-scale real estate company?" Shen Qi asked back.

Old Ou: "Isn't there still you here? If you don't help Xiao Yezi, what's the use of having you as a son-in-law?"

"I..." Shen Qi had a headache, the size of Ouye's mother's company was not in the same order of magnitude as Shen Qi's father's company.Shen Qi didn't fully understand the "father-to-son" business of his own family, and now he is faced with the new issue of "mother-to-daughter" from his wife's natal family.

(End of this chapter)