I just want to be a quiet scholar

Chapter 658
"Qi, when you come to the hospital, bring me something." Ouye called Shen Qi.

Shen Qi looked up documents in his office and said, "Okay, what do you bring?"

Ouye: "Gauss Notebook Volume 15."

"Huh? Do you want to read this volume of Gauss's Notes?" Shen Qi was a little surprised. The document in his hand was the Phillips-Klein edition of Gauss's Notes Volume 15.

There are a total of 20 volumes of Gauss's handwritten notes in German, all of which are kept in academic institutions in Germany and are not for sale.Even Gauss's head portrait was printed on the Deutsche Mark circulated from 1989 to 2001.It can be seen that Germans have great respect for scientists, and the heads of kings, queens or presidents are often printed on the currencies of other countries.

Gauss is the founder of the Göttingen School, and Phillips Klein is the successor of Gauss' Göttingen School.

This Phillips Klein is the same Klein who was driven crazy by his good friend Poincaré.

After going mad, Phillips Klein lost his combat effectiveness in solving mathematical problems. In his later years, he focused on writing the history of mathematics and translated Gauss's 20 volumes of notes into English, French, Latin and other languages.

The English version of Gauss's notes translated by Phillips Klein's handwriting was finally collected by the Institute for Advanced Study in Princeton after several twists and turns.

When Shen Qi returned from the United States, he brought back volumes 15-18 of Phillips-Klein's English edition of Gauss' Notebooks.

The Germans would not hand over Gauss's original notes in any form, and Klein's Gauss notes are also antiques today.

In fact, Gauss Notes has been published a long time ago, translated by the publishing group into languages ​​of various countries and sold all over the world.

But mathematicians with status, status, some spare money, and some sentiments are more willing to collect manuscripts.

Shen Qi's own manuscripts were either given away or exchanged with other collectors.

Klein's English version of Gauss' Notes 15~18 was bought by Shen Qi.

Manuscript cultural relics more than 100 years ago should not be read frequently, otherwise they will be easily damaged.

Shen Qi only took out the manuscripts of scientists in history to look up at the critical sprint moment.

He and his wife, as well as many top mathematicians, believe that there is not only a sharp difference between manuscripts and published printed materials, but also a kind of unproven but vaguely existing spiritual imprint.

"OK, I'll bring you Gauss' notes later, what else do you need?"

"Aunt towel."

"Okay, wait for me, see you in 10 minutes."

Ouye's needs are extremely simple, academic and physical.

Shen Qi brought Gauss' notes and aunt's towel to Ouye's ward as required.

"So my wife, you plan to cut into the rank greater than or equal to 2 from the Gaussian quadratic domain?"

"Well, I think it's feasible. Qi, what do you think?"

"I think it's feasible too, so let's do it."

Shen Qi suddenly felt very complicated.

Ouye couldn't find mathematical inspiration at home, and even fainted.

Once hospitalized, Ouye seemed to have entered a higher academic realm.

Not long after Shen Qi left the hospital, some new reports came out from the international chemical community.

The research team at the University of California, Berkeley said that they successfully synthesized a macrocyclic compound with 20 chiral centers in the laboratory, and the number of isomers is 2 to the 20th power.

"So fierce?"

This was Shen Qi's first reaction after seeing this report.

The Berkeley research team pointed out in the report: "We refer to the research results of the macrocyclic compound of Shen Qi's team at Yanda University and synthesized the macrocyclic compound with the most chiral centers so far. The use of this macrocyclic compound still needs further research. But we've made historic progress in the structure of new compounds."

The University of Tokyo research team said they synthesized a new type of macrocyclic compound with an extremely complex structure in the laboratory.This new type of compound is similar to the chemical structure of sea anemone toxin, the difference is that the key parts are all macrocyclic structures with more than eight members.

The research team of the University of Tokyo also thanked Shen Qi's team for providing the theory of macrocyclic compounds a few months ago. They called the new compound "lighthouse jellyfish hormone". They said that this new compound will help reveal some mysteries in nature. The problem.

Research teams from Germany, the United Kingdom, and Australia also reported their latest research progress on macrocyclic compounds. They proved through experiments that the theory of macrocyclic compounds and new rearrangement reactions proposed by Shen Qi’s team is very reliable. .

"This... this is a bit out of control."

Shen Qi didn't know whether to be happy or worried.

He proposed the theory of macrocyclic compounds. After the introduction of this theory, various fancy new products were derived in the hands of chemists from all over the world.

At present, it is difficult to judge the actual impact that the fancy new compound may bring.

Shen Qi's intuition told him that the emergence of a large number of new macrocyclic compounds is a double-edged sword. It is used to benefit mankind, but it is deviated to destroy the world.

System: "The host has completed the task of chemical promotion to level 14, upgrade!
Conditions for promotion to level 15 in Chemistry:

1. 6000 million Xueba points;

2. Use chemical means to reveal a mystery. "

No matter what, it was a joy to be promoted to level 14 in chemistry.

Mathematics and physics are promoted to level 14, which are all pointed.

The system requires Shen Qi to solve some specific math and physics problems before Shen Qi can be promoted to level 15.

Condition 15 for promotion to level 2 in chemistry is open, and Shen Qi needs to explore it by himself.

Yanda People's Hospital.

Tolerated dosing of triazoctenes was completed in full.

The team of research physicians headed by Professor Qu processed clinical data such as individual number, mean, median, standard deviation, coefficient of variation, geometric mean, and geometric standard deviation through statistical methods.

Combining clinical observation and data analysis, Professor Qu's team believes that triazoctenol has passed the tolerance test, and all subjects will enter the pharmacokinetic/drug efficacy test.

Many literatures have reported that the success rate of new drugs in the clinical research stage is about 10%, that is, only one of the 10 candidate drugs can finally be marketed.

Studies have shown that the main reasons for the failure of clinical development are effectiveness (66%) and safety (21%).

It is the most basic requirement for a drug to have good safety, and it will not kill people without serious side effects.

The core indicator that determines whether a new drug can be marketed is effectiveness, that is, the effect of the drug in treating patients.

In order to avoid the failure of phase III clinical trials for drugs with high research and development costs, in phase I and II clinical trials, it is necessary to carry out proof of concept based on effectiveness as an indicator, so that drugs that are not easy to develop successfully can be eliminated early, so as not to waste money .

Based on the above clinical trial ideas, Ouye finally took triazoctenes again.

(End of this chapter)