I just want to be a quiet scholar

Chapter 670 The Rapidly Growing Shen Nuofi

Ouye's patient friend crawled on the ground in a reptile-like posture, shouting: "What can you do to me? What can you do to me?"

Professor Qu shouted: "He Yuankai, enough!"

The patient suddenly hugged Professor Qu's thigh and burst into tears: "Professor Qu, I am a patient, you have to explain the situation to them, I am a seriously ill patient, they can't take me away! I want to stay in the hospital, I want to Cure!"

Professor Qu waved his hand: "Take him away!"

When the crazy patient was taken away, Shen Qi couldn't help becoming alert, while Ouye had a disgusted expression on his face.

"Old Qu, what's the situation with this He Yuankai? As I remember, he seems to be a triazine clinical trial test subject? Something is wrong with his mind? It shouldn't be a side effect of the drug, right?" Shen Qi was somewhat Nervous, the triazoctenene has finally advanced to the Phase I clinical stage. If there are psychiatric side effects, it will be over!

"He's pretending to be crazy." Professor Qu shook his head and said, "This man is a teacher in the university, and I just received the news that he was investigated for embezzlement and misappropriation of project funds."

Shen Qi let out a long breath, and at the same time was filled with righteous indignation: "Damn! How did such a morally corrupt person be recruited into the test group?"

Looking up at the gorgeous sunset in the sky at a 45-degree angle, Lao Qu said deeply: "In the eyes of doctors, there are only patients and non-patients."

Ouye was indignant: "This man named He is really a scum! He was investigated for embezzling public funds, and he slept with so many female students, so no one cares?"

Shen Qi said: "Students can't write papers or fail the exam, and they go to the teacher to ask for forgiveness. This kind of thing is not uncommon in some universities. A few years ago, I published a paper on mathematical analysis. 80% of the students in the college failed, and some of the students who failed begged me to give them more points... It can't be controlled, the teacher didn't force the students, the students sent them to the door on their own initiative..."

Ouye pinched Shen Qi's waist fiercely: "Shen Qi, I allow you to organize your words and say it again."

Shen Qiyi said righteously: "Take care, I have to take care of it, I have to take care of it! I don't take care of other places, but at Yanda, I must take care of it. After that, the School of Mathematics never invited me to give lectures for mathematics majors. It's the test paper, I haven't issued a test paper for several years."

Ouye asked: "I remember the tragedies of failing grades. It seems that only 30% of the students failed in the end, and you let the remaining 50% go?"

Shen Qi: "I added a few points to those whose true scores were above 50. It is not easy for students to come to Yanda to study, and the questions I asked that time were really difficult."

Ouye became vigilant: "Did you sleep with the female student?"

Shen Qi waved his hands again and again: "No, no, no! Those who come to beg me are all male students. The doctoral students I lead are also all male students."

"Oh."

"Old Qu, let's talk about something serious and go to your office." Shen Qi asked Ouye to go back to the ward first, and he and Professor Qu discussed medical issues together.

After the phase I clinical trials of new drugs have completed the tolerability tests, there are pharmacokinetic and pharmacodynamic tests.

Triazoctenine has now advanced to the stage of pharmacokinetics and pharmacodynamics trials. At this stage, the research team studies the absorption, distribution, metabolism, excretion and time course of drugs in the subjects through PK, and through PD studies Time course of drug action.

Through PK/PD and related mathematical methods, combined with clinical observation, the phase I clinical data of triazoctenes have begun to emerge.

Including Ouye, there are a total of 60 phase I clinical subjects.

As Ouye's husband, Shen Qi is most concerned about the tolerance and pharmacokinetic/efficacy indicators of triazoctenes in Ouye.

As the developer of triazoctenes, Shen Qi also needs to pay full attention to the clinical performance of these 60 subjects, including the previous animal experiment data, as well as the follow-up Phase II and Phase III clinical trials.

Whether a new drug can be marketed depends on its safety and efficacy in the vast majority of target subjects.

Shen Qi certainly hoped that the triazoctenes would eventually be marketed, and his focus gradually shifted to other subjects.

Professor Qu showed Shen Qi the pharmacokinetic/pharmacodynamic model based on 60 subjects, which is currently a semi-finished product and needs to be supplemented with data, but some trends can also be seen.

"Tmax and Cmax are obtained through actual measurement, and AUC0~t is obtained through trapezoidal calculation. We use λ2 to obtain the estimated values ​​of t1/2 and AUCt~inf. It is the main pharmacokinetic calculation method in efficacy and bioavailability studies, and it is also a statutory calculation method in new drug application.”

"However, the parameters obtained from the non-compartmental model are sometimes difficult to use to establish a PK prediction model and conduct PK/PD correlation analysis. Therefore, in this clinical trial, we also applied the compartmental model and conducted rigorous mathematical analysis. Director Shen You see, this is sample 6. After the drug enters the body of sample 6, it is distributed to the target, and after combining with the target, it produces a pharmacological effect, which causes physiological and pathological changes, thereby bringing about clinical therapeutic effects."

"The data of sample 6 is very good, who is this?"

"Sample 6 is your wife."

"Oh, not bad, not bad, quite 6. But the sample is 27, it seems not ideal."

"Sample 27 is He Yuankai, the college teacher who pretended to be crazy and acted stupid just now."

"Look at the overall modeling analysis."

"The overall model is not ready yet, but it's okay. Let's take a look at the process data. Director Shen, we analyzed through LC-MS/MS. Within the range we set, the relationship between the drug concentration and its signal response is determined by It can be described by a weighted linear regression function, or it can be described by a binomial..."

"Old Qu, get out of the way, and I'll help you use binomial description."

Shen Qi volunteered to undertake the calculation and analysis of the mathematical model. After more than half an hour, he completed the binomial description of the overall model.

Compared with the weighted linear regression function description, the binomial description reveals a more detailed relationship between drug concentration and its signal response.

"The winner of the Philippine Award is really different."

The phase I clinical trial of triazoctenene has come to an end, and the main work at this stage is data analysis and processing, and finally forms a written report.When the research team and clinical team apply for new drugs or publish papers, they all speak with data and judge the research results with written reports.

Shen Qi conveniently helped Professor Qu make a binomial description, which accelerated the data processing progress of the clinical team.

It can be seen from the existing data that considering the maximum value, minimum value, and average value comprehensively, the hope of triazoctenene to pass the phase I clinical trial is very high.

With the publication of Ouye's "Strong BSD Conjecture" official paper, many mathematics teams around the world have announced that they have carried out the interpretation and verification of "Strong BSD Conjecture".

These mathematics teams include Bhargava's team from the Clay Institute, Gong Changwei's team from Columbia University, Linden Strauss' team from the Weizmann Institute in Israel, Adama's team from Oxford University, Su Wenxie's team from Shuimu University, and Terence Tao's team from UCLA...

For the interpretation and verification of the "Strong BSD Conjecture", it seems that an academic competition has been formed.

Formal academic institutions and well-known mathematicians on all continents in Europe, America and Asia have taken action, and civil science scholars around the world are not far behind.

A retired mathematics teacher from Ouye High School's alma mater declared on a video website with huge traffic: "After my verification, Ouye's "Strong BSD Conjecture" is established, no need to thank me, this is what I should do."

There is no evidence for the words, the retired mathematics teacher showed several verification manuscripts in the video, which looked very professional.

At the end of the video, the retired mathematics teacher said: "Come to the mathematics class for young geniuses, and help your child win the gold medal in the Olympiad, and the success rate of admission to prestigious schools is as high as 98%!"

"It turned out to be an advertisement!" Netizens complained one after another.

Some netizens also thought: "These days, advertising for training courses also requires technical content. At least this math teacher's verification manuscript looks very professional."

In folk Crouching Tiger, Hidden Dragon, there may really be peerless masters like sweeping monks.

There is no doubt that Mr. Liu, the instructor of the Pomegranate Math Class of the Experimental No. [-] Primary School, is a master.

Teacher Liu is a doctor of mathematics graduated from Fudan University. He is an officer of the Chinese Mathematical Society and once served as the algebra coach of the Chinese Olympiad National Team.

Teacher Liu is very experienced in mathematics competitions. He is a meritorious coach. He has trained Shen Qi, Zhou Yu'an and many other IMO gold medalists with full scores, and helped the Chinese Olympiad team to win the IMO team championship for five consecutive years.

Ph.D. in Mathematics from a famous school, director of the Chinese Mathematical Society, meritorious coach of the Olympiad national team... With such a distinguished experience, why is Mr. Liu willing to work as an instructor of an elite mathematics class in an elementary school?

There must be a shocking secret hidden in it.

"Shen Nuofei, can you solve this equation?" Teacher Liu tapped on the blackboard of the small classroom. He is not a teacher of Experimental No. [-] Primary School. He is an instructor hired by Experimental No. [-] Primary School with a high salary.

There is only one student in the small classroom, she is Shen Nuofei.

Arranged by the mathematics teaching and research group of No. 2 Primary School, when Shen Nuofei, a student in class 2 ([-]), was in class [-] ([-]), she would go to the small classroom and receive the careful guidance of teacher Liu from the pomegranate math class alone.

黑板上的方程是，12-3（9-x）=5（x-4）-7（7-x）

This one-dimensional equation problem is the teaching content of the fifth grade. For most primary school students in the first grade, this problem must be beyond the outline.

But for Shen Nuofei, superclass is normal.

A week ago, this question was beyond the outline.

Now, under the guidance of Teacher Liu, Shen Nuofei has mastered the core technology of the one-dimensional equation.

Shen Nuofei nodded and said, "Ms. Liu, I can answer this question."

Teacher Liu handed half of the chalk to Shen Nuofei: "Come on, write down the steps to solve the equation on the blackboard. If you give the correct answer, then we will immediately enter the teaching of multivariate equations."

(End of this chapter)