I can see the status bar

Chapter 1025 D+4 day
A doctor's job should be to treat the sick, not decide who lives.

In order to solve the morally torturous problem of "who should use the convalescent plasma", Sun Lien thought hard for a long time.In the end, he decided to decide the whereabouts of the plasma from the most objective point of view—the patient should have made relatively rapid progress, and at the same time, the organs of the whole body should not have suffered severe hypoxic damage.

The most important point is that the entire course of the disease should not exceed two weeks from the onset of the disease to the use of plasma.

The change in the number of viruses in the human body is a process that increases exponentially in the first half and begins to decrease rapidly after the peak period.When antibodies start to be produced, the viral load begins to drop rapidly.After the virus is cleared, the antibody will still remain in the human body for a period of time.And after the human body is re-infected with the virus, it quickly produces a large number of antibodies, thereby eliminating the virus that has been infected once.

This whole process is called an "immune response."In this process, the antibody that can efficiently bind to the virus to form an immune conjugate is IgG.IgM antibodies are the first to be produced to fight infection.

IgM antibodies are not very effective in fighting viral infections, but it is IgG antibodies that can really play a decisive role.

At present, doctors have little research on this kind of antibody. After all, the effect and titer of antibodies produced by different diseases, as well as the time of peak appearance are still unclear.The two-week time period proposed by Sun Lien was formulated with reference to the research data of SARS 17 years ago.

A total of 8 patients were included in the study that year as a research sample.The 31 patients showed IgG antibodies for as short as 50 days and as long as 14 days.About [-]% of patients will start to turn positive for IgG antibodies [-] days after the onset of symptoms.

At the same time, most of the patients in the North Fifth District began to have severe symptoms about two weeks after the onset of the disease.And eventually need to be hospitalized for treatment.Two weeks from the onset of illness, such patients are basically the group with the highest viral load.

If their disease progresses rapidly, that often means a less favorable prognosis.At this time, if they can be provided with the serum of recovered patients, the IgG antibodies in the serum can neutralize a large number of viruses and buy more time for them to produce their own antibodies.

About two weeks after the onset, patients with rapid disease progression and no multi-organ failure should use convalescent serum. This should be the most profitable treatment plan at present, and it is also the most suitable time point for convalescent serum intervention that Sun Lien can think of.

Sun Lien sent his preliminary ideas to Song Wen, Lu Zhimin and Professor Li Chengping, and then sent the draft to Dr. Pascal, asking him to help study the plan from the perspective of immunity.

After such a toss, Sun Lien actually had the illusion that he was working hard on scientific research.And it is the kind of scientific research project with a particularly tight timeline.How to treat pneumonia patients infected by the new coronavirus is a big scientific research project.Under this project, the sub-projects that Sun Lien has gone through or is about to go to include PCR test kits, early life support for patients, research on the nature of organ damage in patients, and discussion on treatment options for critically ill patients... Now A study on the immune mechanism of the new coronavirus has to be added.

To say it's effortless is simply a dream.There are so many research projects, each of which is critical to treating patients, and each of which requires a lot of time and money and the energy of researchers to get started.This epidemic is national and even global.Then, it is naturally impossible to rely on a little Sun Li'en for such a scientific research.Filling in the entire Ningyuan Medical College is just a drop in the ocean, and it can't make any waves.

This is a difficult battle that requires all forces to concentrate on tackling key problems.

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"This plan is more complicated, and I need some time." At four o'clock in the morning, Dr. Pascal was awakened from his dream by Sun Lien's WeChat.After getting up cursing with resentment that someone had disturbed his good dreams, it took Dr. Pascal 5 minutes to realize how important Sun Lien had found him again.

After briefly replying to Sun Lien, Dr. Pascal got up from the bed.After kissing Isabella, who was also awakened by the WeChat notification tone, he staggered into his study in his pajamas and slippers.While turning on the desk lamp, he skillfully dripped two drops of eye drops into his eyes, and also pressed a cup of capsule coffee for himself.

Working from four o'clock in the morning is certainly not Dr. Pascale's routine.However, the content of Sun Lien's request for help is really too relevant. Dr. Pascal felt that it was necessary for him to analyze this 28-year-old chief physician whom he had only seen in his life.

As a professional who stayed behind in Ningyuan, Dr. Pascal has been paying attention to various local news in Yunhe.Ningyuan's medical team has been away for almost four days, and the news from the front line is getting more and more frightening day by day.As a doctor who has been to many war zones and has worked under the banner of the United Nations and Doctors Without Borders many times, Dr. Pascal himself has a rare feeling of "fear".

He really couldn't imagine that if he went to Yunhe, he would be able to wear protective clothing without hesitation like Sun Lien and other Chinese doctors, and plunge into the frontline of the fight against the epidemic.

If he hadn't seen how his colleagues in Ningyuan usually deal with patients, Pascal would probably only diverge his thinking in the direction of "these doctors are forced"-this kind of attitude of going to help his compatriots regardless of gains or losses and without hesitation It's not that there are people abroad, but they are indeed a minority.Like Sun Li'en, a doctor who is young and promising, but still insists on going retrograde to the epidemic area, and even threatens to resign and drop the pick... Pascal has never even heard of it.

Courage is contagious.Under the influence of Sun Lien, Pascal also began to experience some small changes in his heart.If he was still in the United States, he would definitely not give up sleep at four o'clock in the morning, and then start working in his pajamas.

"Hey, Linus." When the capital time was still four o'clock in the morning, the French time was still ten o'clock the night before.This is the most energetic time for a New Yorker every day.So, Dr. Pascale's first move was to call his former assistant, "I need you to do me a favor."

Linus, who is currently working at the Institut Pasteur in France, obeyed Dr. Pascal's request - after all, the old Pa had found countless friends and connections to win this position for him.But this request itself... makes Linus feel a little baffled.

"Doctor, this is the research content of infectious diseases." Linus was a little confused on the other end of the phone, "The immune mechanism of infectious diseases... Is this research content your new research project?"

"As a doctor and a researcher in the medical field, our research direction not only needs to meet the previous goals." Dr. Pascal sighed, "Our fundamental research purpose is only one - to save as many lives as possible. Don't you think that protecting life is our bounden duty?"

(End of this chapter)