I can extract side effects.

Chapter 515 Blood vessels disappeared?

"Xue Bo...well, something happened to that lab mouse."

At the door of the office, an intern stood there, said tremblingly, and quickly lowered his head after speaking, not daring to meet his gaze.

Xue Shen raised his head from the computer and recognized the intern, who seemed to be in charge of the laboratory mice, and was immediately puzzled.

"What happened, what happened?"

The first thought was that the mouse had an adverse reaction, did it die suddenly?

Looking back, I felt that it was impossible. Isn’t it just a small piece of femoral artery grafted to the mouse? What could happen?
The intern rolled his eyes and said falteringly: "It seems that, um, the transplanted blood vessel is missing."

With a "bang", Xue Shen shot the case.

"Tell me clearly what it means to lose a blood vessel."

He leaned forward, his eyes were as terrifying as eagles, staring at the interns with full aura.

The intern trembled like a chick and almost cried.

"Xue Bo, it's not my fault. I observe the mice every day. It was obvious at first, and I could even feel the transplanted blood vessels. After the wounds healed these days, I can no longer feel them."

Xue Shen breathed a sigh of relief: "This doesn't explain anything, maybe it's blocked by the muscle layer..."

Before he finished speaking, he knew something was wrong. No matter how the mouse is, it is still an organic living body. With such a long artificial blood vessel, it would not be completely invisible.

"Could it be that it grew together with the meat? There should be a difference. How could it disappear?"

Xue Shen murmured in his heart and came to the laboratory.

As soon as I entered, I saw a few snow-white and pink mice lying on their stomachs in the cage, each of them was full of energy, squeaking, and they were exchanging their experience in postoperative care.

After counting, there were six of them in total, and they were all in good condition. There was no problem at all, so I was relieved.

A week ago, he asked the medical students of the project team to perform artificial femoral artery grafting on these mice.

The operation was very successful, there was not much bleeding during the whole process, and the condition of the mice after the operation was also very good.

He just asked the interns to take care of them. If nothing happened, they would all be executed in a month, and the transplanted blood vessels would be taken out for pathological anatomical examination, and the data would be compiled to create a perfect lab report.

But when the intern came out like this, he suddenly became a little uneasy.

Xue Shen put on gloves, caught a mouse out of the cage, carefully looked at the surgical wound,

It was found that white hair had grown on it, and it was almost healed without leaving any traces.

He touched the grafted femoral artery, and only felt a thick layer of muscle. When he pressed down hard, the mouse screamed in an instant.

"What about my long and thick artificial blood vessel? It really disappeared." Xue Shen was dumbfounded.

What can I do, one month has not arrived yet, the experiment has not been completed, and the samples are gone.

Still unwilling to give up, he touched and touched the mouse, pinched and pinched it.

The mouse howled miserably, and even the surviving mice in the cage looked at him with frightened eyes, and stopped unwillingly.

"No, it needs to be dissected in advance to see what's going on with the transplanted blood vessels."

"It's impossible to disappear out of thin air."

After a while, he made up his mind and stuffed the mouse back into the cage.

The medical student in charge was hurriedly called, took out a mouse, and killed it by intravenous injection of high potassium.

When the transplant surgery site was cut again, the scene in front of them shocked everyone.

I saw that the outside of the artificial blood vessel has been covered by new cells and tissues, wrapped layer by layer, inseparable.

Both ends grew together with the mouse blood vessels, and the sutures were absorbed. The entire femoral artery was almost the same as the original one, and there was no difference at all.

"This..." Xue Shen opened his mouth wide, unable to speak for a moment.

No wonder the intern said he couldn't touch the artificial blood vessel.

What the hell has turned into a real living blood vessel, so it's strange to be able to touch it.

When the artificial blood vessel was first implanted, it was hard and uneven, and the foreign body sensation was easy to feel under the wound.

When it grows together with the new tissue and blood vessels, it is no different from the original blood vessels, and it is difficult to distinguish under the layers of muscle.

The interns are not professional doctors, so it's normal if they can't touch them.

Xue Shen shook his head before trying to understand what was going on.

It turned out that the artificial blood vessels were too similar to the natural blood vessels. After being transplanted into mice, the mice's bodies accepted the material and regenerated new tissue cells in the correct position.

This is because the time is too short, and the artificial blood vessels are not completely fused with the tissue cells.

Over time, the artificial blood vessel will be fully integrated into the body, and it will become exactly the same as the natural blood vessel in terms of appearance, behavior, and function.

"Hahaha, that's great. This is a good thing." After Xue Shen figured it out, he was instantly overjoyed.

However, all of this still needs facts as proof. He hurriedly asked the medical students to take out the grafted artificial blood vessel so that they could observe the internal structure and see what had changed.

Soon, an artificial blood vessel about 3 centimeters long, together with the autogenous aorta of 0.5 centimeters at each end, were taken out completely.

"The graft was well connected to the fontanel aorta in vivo, without any infection, and no necrosis or tearing of the fontanel blood vessels was seen at the site of vascular ligation and anastomosis."

The medical student coughed lightly and explained the results of the anatomy and the observation results of the slices under the electron microscope.

"After the specimen was taken out and cut open, the inner surface of the blood vessel cavity was completely covered with white membrane, and no thrombus was found."

"HE staining under the microscope shows that the artificial blood vessel is completely covered and surrounded by autologous tissue, and the two ends migrate naturally with the normal arterial intima, and the tissue structure from the inside to the outside is basically the same."

"Endothelial cells can be seen growing on the inner surface of the artificial blood vessel, and the endothelial cells near the anastomosis grow well, showing typical uniform paving stone-like changes, and the long axis direction is parallel to the direction of blood flow."

"The number of endothelial cells on the intima surface in the middle of the artificial blood vessel is significantly less than that in the edge, and a large number of fibrous components can be seen. The test shows that the composition is collagen fibers."

"The preliminary conclusion is that the artificial blood vessel has good blood and tissue compatibility with mice, and has a self-healing ability similar to natural blood vessels, with good strength and no deformation."

"The mice were not given any anticoagulant or antiplatelet drugs after surgery, which proves that the artificial blood vessels have high patency and good antithrombotic ability."

"Since the time of implantation in mice is still short, less than two weeks, it is still unknown whether it can maintain stable performance in vivo for a long time."

"Overall, the data and test results show that this is a very ideal artificial blood vessel product."

clap clap clap!
Everyone looked at the bloody artificial blood vessel on the test bench and couldn't help applauding.

"Okay, let's look at the big animal experiments."

"Everyone keep up the good work, come on!"

Xue Shen clenched his fists and waved them excitedly in front of him, and it took him a while to calm down.

The first round of mouse experiments has proved the effectiveness of artificial blood vessels, and next week they can be sent to a third-party animal experiment center for the second round of pig thoracic aorta replacement surgery experiments.

There is no doubt that after witnessing the magic of artificial blood vessels, he has great confidence in his own products.

"Hehe, what the hell are those artificial blood vessels commonly used in the market?"

Xue Shen sneered in his heart, and dismissed the competing products from other suppliers: "As for small-caliber artificial blood vessels, there is really no one who can do it."

"The commonly used Dacron blood vessels can only be used for large-caliber blood vessel replacement surgery and intravascular fistula. Once used for small-caliber blood vessels, thrombus will form in a short period of time after surgery."

"The polytetrafluoroethylene material has good anti-thrombosis ability, but its texture is as hard as the skin of an 80-year-old grandmother's foot. If it is used for surgical sutures, it will be a huge challenge for doctors, let alone 30% of the blood vessels. It's sex, a piece of trash."

"Polyurethane material has good elasticity and can also resist thrombosis. It is barely so rubbish, but it is not stable enough. It will degrade and calcify in the human body. If you dare to use it, you may die."

"As for the natural mulberry silk artificial blood vessel, it's just a gimmick. No matter how small the caliber is, as small as 1mm, it doesn't matter if the strength is so low. Even if the transplantation is successful, it will be sutured. It will degrade naturally after a few months. The Nima bamboo basket fetches water in vain, and the safety of the degraded particles in the human body is hard to say."

"Imported goods are no more than that. As for other domestic products, they are even worse and can't stand up at all."

He has done corresponding market research, and he knows the products of his friends, but he doesn't pay much attention to domestic products.

Because the level of the domestic polymer material industry itself is average, most of the PTFE materials produced are general-purpose products with low quality and belong to low-end products.

In terms of high-end expanded polytetrafluoroethylene materials, there is a big gap between the upstream and foreign countries. Let alone artificial blood vessels, even the supporting medical sutures and heart patches do not have large-scale industrial products in China. It also relies on imports and is very expensive.

Even among high-value consumables, artificial blood vessels are the most high-end ones. Domestically produced blood vessels are really not good in this regard, and the problem of preventing bleeding has not been solved for a long time.

Artificial blood vessels can be said to be both necessary and necessary to the extreme. It belongs to system engineering, an interdisciplinary subject, involving materials engineering, bioengineering, medicine and textile engineering. In order to succeed.

None of the existing manufacturers of artificial blood vessels has a single business, but a large-scale comprehensive medical enterprise, which is used together with high-value consumables such as heart stents.

The two main areas of application are aortic diseases in cardiac surgery and hemodialysis.

Among them, aortic disease accounted for the largest proportion, about 62%.

In China, there are 4 to 5 patients who are going to the hospital for surgical aortic treatment each year. Most of these patients need to be implanted with artificial blood vessels to replace the diseased blood vessels.

The other is artificial vascular fistula, where a thicker artificial blood vessel is implanted in the arm to connect arteries and veins to facilitate hemodialysis, which is a life pathway for patients with kidney failure.

After most patients undergo long-term hemodialysis, the commonly used blood vessels will harden and shrink, and their conditions will deteriorate day by day, so they have to take this last resort to maintain their lives.

But if they have artificial blood vessels that are the same as natural blood vessels, they don't need to do endovascular fistula surgery, they only need to do artificial blood vessel transplantation.

******
Just when the artificial blood vessel project was going smoothly.

The Sanqing farm has also entered the harvest season.

During this period, all the sows have been released from the slaughterhouse. Since the ingredients for feeding are relatively good, the quality of the meat is very delicious, and it has become very popular after being launched in the cafeteria.

Even a devil's tendon pig was slaughtered, and it became a delicious pork chop rice in the cafeteria.

This kind of pork chop is all tough lean meat, it tastes special, and it is limited to the season. It set off a craze in the cafeteria that day, attracting countless diners chasing novelties.

It even became popular in the hot search, becoming a symbol of exotic and delicious food, and driving the tourism business of Sanqing Garden.

So far, Sanqing's cafeteria has become well-known.

Netizens across the country now know that there is a small stall here that often sells some weird genetically modified foods.

It's very popular, if you go late, you won't be able to grab it, and you can only drink the most common special alcohol Zhanlang milk.

Wei Kang also likes the special food in the cafeteria very much, and he gets his lunch there every day.

Of course, he always ordered takeaway, and then asked the security guard to bring it up.

In addition, the farm also sent a few muscle pigs over, and a few chickens every week.

Therefore, Wei Kang specially remodeled the basement and added a refrigerator to store food conveniently.

In this way, it is guaranteed that he can enjoy the organic meat from the farm for breakfast, lunch and dinner.

On this day, Wei Kang got off work on time again and just returned home.

Then came the biggest surprise of my life.

"What? Are you pregnant?"

Wei Kang looked at his wife who flew into his arms as soon as he entered the door with a dazed expression, and he was completely dumbfounded.

It took a while to jump up, and I was so excited that I couldn't stop walking around.

There are still words like "Great, I finally have it" in my mouth.

It wasn't until my wife hummed dissatisfiedly that she obediently sat down on the sofa.

The two sat hugging each other, Wei Kang still couldn't restrain his joy, he caressed his wife's abdomen with both hands, and smiled from ear to ear.

Jian Lianyun nestled in his arms, with a motherly smile on her face, talking about the experience of the day.

"Hey, I have been trying for so long, but there has been no movement, and I have long forgotten about it."

"I've been too busy these past few days, so I realized I haven't come to that one. I went to the bathroom at noon and saw this pregnancy test stick in my bag, so I thought about using it up."

"I didn't expect to be hit, so I hurried to the gynecology department for an examination in the afternoon, and it was officially confirmed."

"Hey, sure enough, you can't keep thinking about this kind of thing. The ancients are right. Planting flowers with intention will not bloom, but planting willows and willows will make shade without intention."

"Husband, you say yes."

"En." The smile on Wei Kang's face never disappeared for a moment, and happiness flowed from the corner of his grinning mouth.

I feel light and light all over, as if dreaming back to space, and even the air I breathe has the scent of candy.

My mind was in a mess, and each thought was like a revolving lantern, flashing non-stop, and I couldn't control it at all.

"I have a child, parents, do you hear me?"

"Old Wei's family has a queen."

"What should the child be named?"

(End of this chapter)