Doctor's Life Simulator

Chapter 320 Contributing to the Three Most Authoritative Journals in the World "Cell" Magazine

Seeing that Qin Lang made a choice, Ming Dong was also very happy, and at the same time, he was going to investigate Qin Lang again. If this little guy can really make some achievements, then he should be recruited and invested.

"Doctor Qin, I hope this cooperation will give us a good start for each other."

Ming Dong shook hands with Qin Lang, and he really admired Qin Lang, a young man.

So she also intentionally asked her daughter to send Qin Lang off, so that they could communicate and understand more.

Not to mention the talent in pharmaceuticals, at least in other aspects, Qin Lang must be very good, otherwise it would be impossible to win the favor of Shen Xi and Wu Jizong, moreover, he has made so many achievements at such a young age.

Even her own husband, the chief dean of the Second Affiliated Hospital of Zijingang, was not so outstanding when he was young.

Ming Dong also praised Qin Lang for starting from the most basic animal laboratory.

After all, she came up step by step from the grass roots.When Ming Dong was young, she was also an amazingly talented woman who graduated from the Karolinska Institutet.

The Karolinska Institutet is one of the world's leading medical universities, especially its pharmacy and pharmaceuticals, ranking among the top three in the world, second only to Harvard University and the University of California, San Diego.

After graduation, Ming Dong worked for Pfizer for five years before returning to Ming's Pharmaceutical Group. He started as an ordinary pharmacist, and now he has inherited his father's mantle and has become a real giant in the pharmaceutical industry in Zhejiang Province.

After Ming Dong arranged for Tang Yue to be sent to Qin Lang, she also rushed to the next meeting. Her work intensity was still very high.

Tang Yue didn't expect that Qin Lang and his mother had reached the first cooperation in this way. Although she didn't have much interest in pharmaceuticals, the basic situation was still clear.

I also have some understanding of animal experiments in the process of developing new drugs.

As for Qin Lang's choice, she actually didn't quite understand it.

According to her judgment, the chances of producing results in the field of animal experiments are very small, which is not a good research direction.

It's just that Qin Lang is a very assertive person and doesn't listen to his own opinion, so Tang Yue didn't say much, all she could do was support him silently.

"Qin Lang, then you can come with me."

Qin Lang is of course very grateful to Tang Yue for his help: "Thank you then."

Not much, about the inbred line breeding of the mice this time, I don't plan to reveal too much to her, and I will talk about it after the results are published and the paper is published.

After Qin Lang sat on Tang Yue's red horseman, he thought about the follow-up arrangements on his own.

Regarding this, Tang Yue also understood very well, and didn't want to disturb Qin Lang, so she drove quietly.

In about half an hour, the two arrived at the test base.

After achieving his goal, Qin Lang basically had a complete plan.

For Tang Yue's silence along the way, Qin Lang still has a good impression. After all, he doesn't like a girl who chatters endlessly when he is thinking about important things.

The two soon came to the animal experiment base located in the suburbs of Xiaoshan District.

The entire base covers an area of ​​more than 500 mu. As soon as you entered the gate, you saw the planning plan of the entire park. Tang Yue briefly introduced it to Qin Lang.

In the entire park, more than half of the area is used to breed and breed mice.

Qin Lang randomly circled a [-]-square-meter rat house in the area Tang Yue pointed out.

Behind Qin Lang and Tang Yue, an uncle in his forties had already walked over. He was Wu Qingguo, the manager of the base.

Wu Qingguo's appearance is a bit sloppy, especially the bald head with a ring of miscellaneous hair, which blows in the wind and gives people a sense of the evil god of fire cloud. However, under the sloppy and casual appearance, there is a pair of deep eyes.

It's not easy to be the person in charge of the animal experiment base of Ming's Group.

Wu Qingguo is also a graduate of the serious Huaguo Pharmaceutical University. He can be regarded as a serious professional talent in China. He also entered the field of animal experiment research from the university. Improved design of the mouse rack.

It can be said that in the field of animal experiments, I have gained a lot of experience and spent a lot of hard work, but my luck is not very good. The papers I researched and the patents I applied for did not cause much splash.

After all, in the field of mice, foreign standards are used as the standard. Domestic pharmaceutical companies would rather spend more money to introduce mature and advanced foreign technologies than invest in their own domestic scientific research projects.

Wu Qingguo also went to work for Huaguo Johnson & Johnson Pharmaceutical Group for a period of time, but he didn't get much attention.So, after working for six or seven years, he became a Buddha, and returned to Xiaoshan, Hangzhou without any desire or desire, and joined Ming's Pharmaceutical Group.

The animal experiment base here is not an important field for the Ming Group, and the animals cultivated are ordinary Kunming, and there are not too many requirements from him.

Therefore, Wu Qingguo is also good at making no mistakes.

Standing aside, listening to the exchange between Tang Yue and Qin Lang, he roughly understood that Qin Lang is a graduate student of Zijingang University, doing research in the field of animal experiments, and Ming Dong valued and invested in him, providing him with free venues and The experimental mice, as well as the cooperation of the staff such as myself.

Regarding this, Wu Qingguo didn't have too much ups and downs in his mood, nor was he too optimistic about Qin Lang's research. After all, no matter how hard he tried in the field of mice, he couldn't break through the mature foreign system, nor could he cause any big waves.

Zijingang's master's research on experimental animals is not as important as the research he did at the University of Pharmaceutical Sciences.

"I hope this kid doesn't get too deep into himself. After all, the research on experimental animals is not of much value and will not produce much output."

Wu Qingguo sighed in his heart, but he didn't express it. Moreover, in his opinion, this young graduate student probably just took some mice from here for free for research.

"Qin Lang, I don't understand more professional things about animal experimentation. If you need anything later, you can explain to Master Wu. He is very professional. Everything in the [-]-square-meter area is at your disposal. .”

After Tang Yue confessed, she prepared to wait for Qin Lang in the car outside. In fact, she was not very interested in these mice.

"Doctor Qin, let me go to the mouse house to have a look."

Wu Qingguo led the way lazily. In his opinion, this young man was only 3 minutes hot.

"Okay, Master Wu will trouble you later."

Qin Lang smiled slightly and followed Wu Qingguo.

Soon the two of them came to the Shushe area belonging to Qinlang.

As soon as he walked into the rat house, Wu Qingguo began to introduce it. After all, this was his only pleasure here:
"The quality of the breeding facilities and feed of experimental animals and mice directly affects the quality of the mice. Choosing the best breeding facilities and feed is the key to raising mice. Classification management and optimized breeding to improve the production of laboratory mice are also bases. greatest pursuit."

Qin Lang agrees very much. He has countless knowledge in his mind about the mouse information unlocked through the animal laboratory, and he is just trying to prove it. After all, he will start breeding mice, and these mouse houses are his cash cow. Of course To adjust to the optimum.

Wu Qingguo led Qin Lang into the first rat house, and then introduced:
"Doctor Qin, this mouse house looks ordinary, but it is actually very particular. The reason why it is designed like this is because mice like dark and quiet environments, are very sensitive to ambient temperature and humidity, and cannot withstand sudden changes in temperature." change and excessive temperature."

When Wu Qingguo introduced it, Qin Lang also blurted out:

"Mice raised artificially for a long time do have poor adaptability to the environment and are not resistant to cold and heat. They are required to live in a clean and dust-free environment with fresh air, a temperature of 18-22°C, a relative humidity of 50-60%, and a noise below 85 decibels. In an environment with an ammonia concentration of 20PPm and ventilation of 8 to 12 times per hour."

Qin Lang walked directly in front of the monitoring equipment, looked at it carefully, and said approvingly:

"Master Wu, your control here is still very good, but the ammonia concentration and relative humidity still need to be optimized."

Listening to Qin Lang's question, Wu Qingguo was stunned. Of course he knew the optimal condition Qin Lang said, but in reality, in China, many rat houses are just as good. Moreover, the rats in this rat house are originally Ordinary grade not SPF grade.

"Is this young doctor an expert?"

Wu Qingguo put away his lazy thoughts for a while, while Qin Lang went straight to the feed place of the mouse house, squeezed it out with three fingers, and then smelled it, his face changed slightly, obviously not satisfied:
"Master Wu, your feed formula needs to be improved!"

Wu Qingguo frowned. The feed he used was the most commonly used type of feed in China, and the sanitation and cleaning were well controlled. Qin Lang said so, but he was slapping him in the face.

Wu Qingguo's tone was a bit cold: "Doctor Qin, you can't talk nonsense about this. I have used this feed for decades, and there will be no problem."

Qin Lang turned his head to look at Wu Qingguo, and said calmly: "Of course the feed can be used in this way, but I think it can be more optimized."

Wu Qingguo was taken aback for a moment, this young man was really brazen, and he said unconvinced: "Oh, then please ask Dr. Qin for guidance."

Qin Lang pointed to the growth and feeding record card on the wall of the mouse house, and said: "Mice are omnivores, and their stomach capacity is small, usually 1.5-[-] milliliters. This basic feeding amount is not a problem."

Hearing what Qin Lang said, Wu Qingguo nodded slightly. Unexpectedly, this doctor Qin knew the market quite well, and it seemed that he had done a lot of homework.

"However, Master Wu, have you ever paid attention to the feed consumption of mice, which varies with different stages of growth and development and production and reproduction. For pregnant female mice, the feed consumption gradually increases. After 12 to 21 days after delivery, The pups began to open their eyes, and their weight increased. The amount of milk and feed required also increased. From 21 days old to 35 days old, the daily feed consumption increased from 4 grams to 5.5-6 grams, and the body weight increased the fastest. After 35 days of age, it gradually stabilized. Therefore, the feeding of mice must be carried out according to the growth and development characteristics of different stages, and obviously, the current feeding amount and the growth cycle of mice are not perfectly combined."

Hearing Qin Lang's analysis, Wu Qingguo was taken aback for a moment. Of course, he knew that the amount of feed used in different stages would be different, but they were fed roughly according to experience, and he never thought of being so precise.

Moreover, he arranged the feeding of the entire experimental base before, and he has the most experience. His leader in charge doesn't understand at all, and he doesn't pay attention to such details.

Wu Qingguo looked at Qin Lang's young side face, his old face blushed slightly, but, why is this doctor Qin so young, and how can he be so familiar with the details of this kind of feed?

Qin Lang continued to walk around the rat house, and then walked to the position of the newly opened and newly weaned pups, and continued to add:
"Pups can be fed with high-nutrition granules or soft materials to meet their growth and development needs. As for lactating female mice, in order to increase lactation, they should be fed sunflower seeds throughout the lactation process, controlled at 1 gram, approximately In 12 capsules. Then, cod liver oil and vitamin dosage should also be optimized in conjunction with the growth cycle, and then I will give you a detailed feeding plan.”

Qin Lang said calmly, and then continued to signal: "Master Wu, show me other areas."

Wu Qingguo nodded immediately, and the contempt in his eyes had completely disappeared. This doctor Qin is really amazing.

"After I decide on the formula of the feed, I will feed them all according to the formula. Remember not to change them frequently. Unstable feed varieties will cause growth stagnation and reduced fertility of the mice."

Qin Lang gave another instruction.

Wu Qingguo opened his mouth, but couldn't utter a word.

In the past, every time my leader came to visit the rat house, he was always eloquent while the leader listened carefully.A timely sentence: OK, Master Wu, everything is based on your experience!

This time, in front of this young man like Qin Lang, Wu Qingguo felt a lot of pressure.

After another inspection, Qin Lang provided some comprehensive and systematic optimization suggestions for mouse boxes, mouse racks, drinking fountains, and bedding according to the advanced theories related to mice provided by the drug research and development laboratory.

As a result, Wu Qingguo had the illusion that Ming Dong was a consultant expert invited from a top animal laboratory abroad.

Half an hour later, Qin Lang finally inspected the [-]-square-meter rat house that belonged to him.

"Master Wu, according to the suggestions I put forward today, we will improve and optimize the five-hundred-square-meter rat house. I will come back in a few days and make arrangements for the next work."

During this inspection process, Qin Lang has already thought about the next arrangement. After returning to his teacher's tumor prevention and treatment center, he plans to adjust the research and development of new anti-tumor drugs to the induction and breeding of ICR inbred mice.

Then, with the help of the laboratory of the Cancer Prevention and Control Center, the first batch of ICR mice were induced and bred, and sent to the rat house of Ming's Pharmaceutical Group for breeding and mass reproduction, earning the first pot of gold.

When Qin Lang was thinking about the next plan, Wu Qingguo finally couldn't bear it anymore and asked:

"Doctor Qin, it will cost a lot of money to improve according to your plan. Although it can indeed increase the reproductive rate and growth speed of mice, the cost and benefits paid are not too cost-effective."

"Moreover, I believe that the improvements you proposed can be achieved in top foreign animal laboratories, and are even being implemented. So what is the significance of your research?"

Although he admires it, from his experience and vision, Qin Lang's small-scale optimization does not have much research value.

Perhaps for a master student, it is possible to write a thesis, but from the perspective of a pharmaceutical company of the size of Ming's Pharmaceutical Group, it is tasteless, tasteless to eat, and it is a pity to discard it, which is not so amazing.

Qin Lang said mysteriously to Wu Qingguo: "Of course, this is not my research content. These are just some random improvement requirements. The purpose of my visit to the experimental base this time is to optimize and improve the Kunming white mouse itself. "

"Ah? Improvement Kun understands."

Wu Qingguo was shocked by Qin Lang all of a sudden, and even a flame flashed in his eyes, and he soon regained his senses.

Kunming understands the stable inbred strain that has been cultivated after several generations of improvement and optimization in the world. How can a young man break through as soon as he can say it.

However, when the words came to his lips, Wu Qingguo directly held back, because he didn't want to hurt young people like Qin Lang who were still passionate.

After all, this kind of innocent young man full of passion and fantasy is so similar to him back then. Although the result is bitter, there is always some joy in the process.

In addition, he doesn't want to be troublesome, anyway, Ming's Pharmaceutical Group is not short of money, so let's do it.

Moreover, this [-]-square-meter rat house was originally given to Dr. Qin by Ming Dong casually, and it stopped playing after half a year or a year.

Wu Qingguo completely regarded Qinlang, a project with a high probability of failure, as a little adjustment and fun in his boring life.

"Doctor Qin, I will report your plan to Dong Ming. Then we will see you next time."

Wu Qingguo and Qin Lang confirmed the next optimization plan. After Qin Lang explained, he left the mouse house.

Tang Yue had been waiting for him in the car for a long time, when she saw Qin Lang coming, she waved:
"Qin Lang, let's take a look at it casually today, and I can ask Master Wu for advice later."

Tang Yue looked at Master Wu again, with a playful tone: "Master Wu, you can't hide your secrets!"

Wu Qingguo looked at the chairman's daughter and couldn't say anything. It's not sure who is the student and who is the teacher.

"Miss Tang, I am serious. Dr. Qin's knowledge in raising and cultivating mice is very profound. In some respects, I have to learn from Dr. Qin."

Listening to Wu Qingguo's words, Tang Yue was a little stunned. She knew very well that Master Wu was a noble person with a high vision, so she went in for a chat and was impressed by Qin Lang's talent?

Tang Yue blinked, this is really Qin Lang's usual style.

It's just, when will he know how to raise and breed mice again!

Professor Shen even teaches this?
When Tang Yue took Qin Lang back to Zijingang No. [-] Hospital, Wu Qingguo also began to arrange the staff below, and started to make a budget according to the plan Qin Lang had arranged before.

Not long after Qin Lang and the others left, Chairman Ming specially called Wu Qingguo to ask his opinion on Qin Lang.

Wu Qingguo reported Qin Lang's ideas and plans in detail.

After listening to it, Ming Dong was a little surprised. He didn't expect that Dr. Qin was really skilled in raising and cultivating mice at such a young age.

As for Qin Lang's ambition to improve and optimize Kunming, Director Ming was noncommittal, but more or less, he paid more attention to Qin Lang's movements.

"Next, fully cooperate with Dr. Qin to complete his research. Funding and resources are not a problem. The progress of the entire research can be reported to me at any time."

Ming Dong gave some instructions and then hung up the phone. Rather than being interested in this subject, she was more interested in Qin Lang's potential.

After Qin Lang returned to Zijingang No. [-] Hospital, he went to the desk specially arranged for him by Shenxi, and began to write a thesis "Through cyclophosphamide (CP) and colchicine (colchicine, COL) on traditional Kunming Chromosomal aberration experiments in white mice, a theoretical study on the breeding of improved ICR mouse inbred lines.

After publishing several previous papers, Qin Lang is already a skilled worker. Besides, with the information of the mice in the drug research and development experiment, Qin Lang wrote a paper of more than 6000 words very smoothly.

After the thesis, Qin Lang theoretically discussed the experimental method of improving mice, created a new system, and highlighted the traits and advantages of a new generation of improved ICR mice, which have good maternal nature, particularly docile temperament, and strong physique , growing rapidly.

After completing the thesis, Qin Lang directly submitted this theoretical research to the "Cell" magazine.

"Cell", "Nature" and "Science" have become the three most authoritative journals in the world.

These three journals are the journals that most researchers most expect their work to be published in. Two established journals, Nature and Science, publish articles in a wider range of disciplines.

Since "cell" was founded in 1976, it has become one of the most famous journals in the field of natural science research in the world. "celll" mainly publishes important original scientific research reports, and many of the most important discoveries in the field of life sciences All published in "cell".

For example, the very famous "artemisinin" in China: it originated from the discovery of the Chinese herbal medicine garden, and this article was published on it. It was through this method that Tu Aoao and her colleagues caused a huge sensation in the world.

As another example, another very famous article analyzed the relationship between population genomes and the complex framework of human diseases, arguing that the large amount of data obtained from whole genome sequencing, the Thousand Genomes Project, and targeted genome sequencing revealed a wealth of rare , individual mutations, which may account for the greater impact of recent mutations on disease susceptibility and protection than ancient mutations.

And so on various important research results, many of the world's big cows have published papers on it.

After Qin Lang finished submitting the manuscript, he began to design his own topic, and was going to go to Shen Xi to report it first.

ps: Three chapters in one, one of which is a previous supplement.Thank you for your support~

(End of this chapter)