Rebirth 90: I opened a hospital in Shencheng

Chapter 159 Rapamycin!

"Doctor Nie, I am Lao Li, the driver of our Provincial Research Institute, please sign this handover form."

Nie Chen was about to observe the pile of melanoma on Kuang Fuliang's face, which was close to skin cancer.

Lao Li, the driver of the Provincial Research Institute, who had already parked the car, approached Nie Chen holding a watch clip specially designed for handing over patients with the Aihua Clinic.

Nie Chen took the handover form handed over by the driver, and carefully read the contents on the handover form.

During the tabulation process on the form, it has been indicated that the handover unit is the Guangdong Medical Research Institute and the Shencheng Aihua Clinic.

The patients handed over are not labeled as patients, but as experimental subjects for the vascular malformation and vascular tumor projects.

Nie Chen swiped and signed the handover form.

The driver, Lao Li, solemnly handed over all the inspection report files belonging to the patient Kuang Fuliang to Nie Chen: "Dr. Nie Chen, the next treatment of Mr. Kuang will be transferred to the Aihua Clinic. Go back to Huacheng and report to the office."

"No problem." Nie Chen put away the file bag, took the driver Lao Li's big hand and shook it up and down.

Then Nie Chen, Li Dayong, Lin Ronghua, Liu Yueqian, and Chen Chunmei walked out of the glass door of the outpatient clinic together, watching the driver Lao Li drive away in the van.

"Two years ago in the Department of Plastic Surgery of the Affiliated Hospital of Sun Yat-Sen University, I had a vascular tumor resection. The current situation is that the disease has relapsed, and the tumor is almost turning into melanoma."

Nie Chen browsed through the full-body report given by the provincial research institute with a solemn expression.

In the case of vascular malformation and vascular tumors, if there is no corresponding targeted drug that blocks the mutation of the vascular malformation gene after surgery, postoperative care and treatment will be performed.

Then the recurrence rate after surgery is almost 90.00%.

"Doctor, is my condition still necessary for treatment?"

Patient Kuang Fuliang, after Nie Chen carefully examined the layers of extremely disgusting and evil fat tumors on his cheeks.

With tears in his eyes, he asked with trembling lips, "Director Zhou at the Department of Plastic Surgery of the Zhongshan Affiliated Hospital has already judged that the tumor that I have recurred has no way to treat it. Whether it's surgery or medication, it's gone. There is no way to treat it, and it is basically determined to be terminally ill. If there is no way here, then we will not waste time."

"It can be treated, but the treatment cycle may be a little longer."

Nie Chen comforted the fat man Kuang Fuliang, who was about 1.8 meters and a half tall, and had dark skin, and asked him to sit on the side of the couch.

At the same time, Zhong Lanlan was asked to take out Lin Xueyang, who also belonged to vascular tumor resection, and the recovery is very gratifying, and has passed the dangerous period of vascular tumor recurrence. After the operation, he compared the photo album and showed it to Kuang Fuliang.

Nie Chen pointed to the five books that were placed on the coffee table in front of Kuang Fuliang, which belonged to Lin Xueyang's comparison photos before and after surgery.

He smiled and said: "This female patient's vascular tumor location is similar to yours, but she has not undergone primary resection. Your recovery time may be about three times as long as hers. But it’s still within the treatable range.”

"Can it really be treated?" Kuang Fuliang, who was originally nervous, slowly opened the album of Lin Xueyang on the coffee table in front of him.

When he opened the first photo album that Lin Xueyang left before the operation, Kuang Fuliang didn't show any expression.

And in the second book, Lin Xueyang's photos on the third day after surgery.

Kuang Fuliang sat up straight at once, carelessly, his brows frowned into a word of Sichuan, his expression was extremely nervous, and he held the photo album from the coffee table to less than two slaps away from his eyes.

Then he read page by page slowly, and saw the last book, which was the photo Nie Chen took of Lin Xueyang's Home Nursing Center on Saturday.

In the latest photo album, Lin Xueren is radiant and beautiful.

On Lin Xueyang's face before the operation, the layer upon layer of strawberry-shaped, terrifying, evil, and ugly vascular tumors had disappeared.

In the photo, her face is rosy, but after surgery, the sutured position of the skin flap is actually only a thin red line scar left.

Papa papa.

Looking at the photos of Lin Xueyang with the shooting date and time, Kuang Fuliang blinked, and the tears of soybeans burst out of his eyes: "Doctor, can you really cure me of this disease?"

His expression was as if he had been rescued ashore before dying of drowning and suffocation.

Terrified and humble, he was waiting for Nie Chen to answer his words.

And Nie Chen's words are obviously to him, the sentence for the rest of his life.

"Your condition can be treated." Nie Chen said it again, and stopped writing in his hands the treatment plan for the vascular tumor project that could be launched.

Covering the cap of the pen in his hand, he looked at Li Dayong, who had been silent after the patient entered the clinic: "Now our project on vascular tumors will start directly from Mr. Kuang."

As Nie Chen said, he took out a small tube of ointment in a plastic case from the drawer. The plastic case of the ointment did not write down what kind of ointment it was.

In addition to this ointment, Nie Chen also took out a small pill wrapped in a small paper.

Handed the list with the treatment order to Li Dayong: "Professor Li, for the first three days, you only need to apply a thin layer of ointment to Mr. Kuang's affected area, and at the same time take a pill at nine o'clock every morning. , when swallowing the pill, it should be taken with the juice squeezed from grapefruit meat."

Li Dayong nodded frequently, and took the list from Nie Chen.

Then put it away again, Nie Chen put the ointment and the pills in the paper bag in front of him, without asking, but simply replied: "Doctor Nie, there is no problem."

Even without Ke Weiguo, Du Ke, and He Guangtong, the three of them are here in the outpatient clinic.

Li Dayong already knew that Nie Chen had an exclusive channel for some special medicines and specific medicine supply sources.

He will not talk too much about the use of this medical source that belongs to Nie Chen's exclusive patent.

That is to say, Nie Chen had given the patient a blood vessel contrast agent for vascular CT before, and the effect of the angiographic CT contrast film produced was so amazing that Li Dayong asked Nie Chen several times about the principle and source of blood vessel visualization.

"Doctor Nie, our provincial medical research institute and the Aihua clinic jointly established the vascular tumor research project. It shouldn't be too late for the research office of our military hospital to participate now, right?"

After most of the day, Ke Weiguo, as an expert researcher, no longer had any doubts about Nie Chen's medical background and technical abilities.

Even if it is a vascular malformation, vascular tumors are a long-standing problem that international plastic surgery specialists have never been able to overcome.

That is to say, after the resection of the vascular tumor, the tumor will recur at a faster rate.

Obviously, this situation has been effectively curbed by Nie Chen's previous surgery.

And the bottle of unlabeled ointment that Nie Chen brought out to Li Dayong just now, and the handful of ordinary little pills, definitely have something in them.

Ke Weiguo laughed so hard that his brows stood upright. He took the initiative to stand up from the couch, walked to the side of Nie Chen's short sofa with a sonorous and forceful step as if he had measured it, and held Nie Chen's shoulders.

He said confidently: "Let's make a deal like this. On behalf of the plastic surgery department of Huacheng Military Hospital, I will participate in the project of our Aihua Outpatient Clinic. The conditions, Dr. Nie, you mention! I can speak, and what I say counts!" "

Nie Chen was amused by Ke Weiguo's changing attitude throughout the day.

He said with a smile: "The subject project of vascular tumor and vascular malformation is indeed a project with as many people as possible. However, the reason why I will cooperate with Professor Li Dayong on this project is because Professor Li Dayong transferred my file to the Provincial Research Institute , and at the same time led me this project whose funding is fully borne by the provincial research institute. If our military hospital wants to participate in this project, if only patient resources and medical students are available, then the Aihua Clinic and the provincial research institute will suffer too much gone."

"What are you talking about!" Seeing that Nie Chen didn't reject him, Ke Weiguo was elated when he saw that Nie Chen didn't reject him, and even offered himself a condition, "Funding the laboratory and the resources that can be mobilized are just a matter of Dr. Nie's words!"

On the other hand, Lin Ronghua and Liu Yueqian were confused when Ke Weiguo suddenly became excited and told Nie Chen about the content of the negotiations.

Why did Nie Chen show Li Dayong the ointment and a pack of small pills, and asked Li Dayong to conduct an experiment on a vascular tumor project, and Ke Weiguo immediately said that he would participate in this project?
"Doctor Nie, before I came to the Aihua Clinic, I asked Xiao Li from Huacheng Biological Laboratory what is it that you asked the pharmaceutical supplier Zhang Xin to make this kind of medicine that is different from other types of mycin? Xiao Li also said no. Clear the use of the medicine, because you did not tell them how to use it."

Ke Weiguo, who was incomparably a chicken thief, asked Nie Chen for the specific name of the ointment and pills that Nie Chen took out, "Can you tell me what the name of your medicine is?"

"Rapamycin." Nie Chen replied frankly with a bright smile.

This drug is a new drug that will be launched in the United States in [-], nine years later.

However, when it was first launched on the market, it was a specific drug for renal transplant rejection.

Then, in the process of renal transplant rejection, it was found that rapamycin is a specific targeted drug that can block vascular malformation, vascular tumor vascular lesions.

In the 90s, it was very difficult to obtain and purify rapamycin.

This drug is currently only available in laboratories and is more expensive than gold.

However, after 2010, after the purification and extraction prescription of rapamycin spread to China, experts in the domestic biomedical industry went through industrial configuration and invented a method for obtaining rapamycin fermentation liquid by using actinomycetes mobilis. method.

However, this method only needs a two-liter fermenter to continuously cultivate the rapamycin fermentation broth with motile actinomycetes.

And Nie Chen was in full cooperation with drug supplier Zhang Xin a few days ago.

He directly handed over the method of fermentation and purification of rapamycin to Zhang Xin, and asked him to entrust Huacheng Biological Laboratory to carry out fermentation and purification, and then buy the purified crystal from the other party at a price of one gram.

As for the motile actinomycetes that can produce rapamycin, as long as the biological laboratory procedures are complete, they can directly apply for or purchase from the China General Microorganism Culture Collection and Management Center.

However, Zhang Xin, the drug supplier, still provided the fermenter, and applied to the China Common Microorganism Culture Collection and Management Center for the no.

They didn't understand the actual use of the mycin crystals purified from the rapamycin fermentation broth.

"Rapamycin?" Ke Zhengguo was confused and in awe. He swallowed and said excitedly, "Is this a specific drug for treating vascular malformations?"

Nie Chen nodded: "Yes."

(End of this chapter)