From small clinic to medical empire

Chapter 292 Bad Premonition

The National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health.

NIAID is said to be an institute, but it is actually a large-scale medical and experimental institution.

And the person in charge here has not changed for 36 years.

He is one of the most famous infectious diseases scientists in the world, Dr. Anthony Fauci.

Unlike many researchers at the institute, Anthony Fauci is licensed as a practicing physician.

So he has two days a week to visit the doctor.

But more time, he still participates in research in the laboratory.

It is not only necessary to analyze the potentially threatening infectious disease pathogens found across the United States, but also to formulate a reasonable response plan in accordance with scientific methods and submit it to the federal government.

It can be said that, to some extent, Dr. Fauci is the sentinel lymph node of the United States.

"Doctor, a case of Ebola virus carrier was found in the Miami area. The patient has died. He entered the country from the Democratic Republic of the Congo last Monday. The flight he took was..."

Fauci squeezed the center of his eyebrows, the third outbreak of the Ebola epidemic in West Africa has been going on for some time.

This virus, which has a very strong lethality rate and a very short death time, will break out in West Africa every few years.

North America and West Africa are separated by the Atlantic Ocean, and the risk of infection has always been high.

Fortunately, the virus is not very contagious.

First of all, although the high death rate and the fast death time make the people feel creepy.

But in fact, such characteristics reduce the possibility of human-to-human transmission of the virus.

After all, if the patient is taken away quickly, the risk of infecting others will naturally be reduced.

Secondly, Ebola virus cannot spread through the air.

It can only be spread by contact with the blood, secretions, organs or other bodily fluids of an infected person.

Poor medical and sanitation conditions in West Africa, as well as some strange funeral ceremonies, contributed to the contagiousness of Ebola virus.

But in other parts of the world, its spread has been markedly slower.

But even so, in the past three months, there have been more than 54 Ebola cases in North America, with [-] deaths.

A full 54 Americans died!
This made Fauci feel the pressure on his shoulders.

To make matters worse, flu season is at its peak.

Healthcare systems across North America are facing severe challenges.

……

After giving instructions on the treatment plan for this new case in Miami, Fauci couldn't help but think of the joint laboratory far across the ocean.

That is the joint laboratory presided over by his student Oliver Jenny and the outstanding Chinese doctor, and what is going on in it is enough to change the history of human medical treatment, no, it is the research of human history.

Sitting back in the office, the assistant has prepared Dr. Fauci's favorite coffee.

While drinking coffee, he picked up the research materials that Jenny had sent back.

The expression of genetic material in organelles is a virgin land that has never been explored before.

Recent research results have repeatedly increased Fauci’s attention to this project.

"Teacher, in the past week's research, I, Morris, Harvey, and my colleagues in China have completed the implantation of the AHG-B protein compilation program on the mitochondrial DNA."

"Although the core microcircle gene editing work is still under the control of Dr. Zhang, in other experimental links, Chinese colleagues have shared experimental data with us in a noble scientific spirit.

At the same time, the editing template and scale replication technology we provided also played a key role in the experiment. "

"In the next week, we will continue to conduct experiments in the hope that the experimental carrier cells can successfully synthesize and secrete AHG-B protein. If successful, this will be the first time we have verified that we can control cell protein secretion by controlling organelle DNA." sex."

……

AHG-B globulin is a relatively common indicator protein.

But common doesn't mean it's unimportant.

This is a globulin closely related to blood clotting function.

The joint laboratory chose to compile this protein as an applied experiment, not only because AHG-B itself is common, but also to explore the possibility of using this technology to treat hemophilia patients.

Seeing the progress of related experiments, Dr. Fauci took a sip of coffee with a smile.

Although hemophilia treatment is not closely related to his own profession, it is just the beginning.

If AHG-B can be successful, then other protein expression genes can naturally be successfully implanted.

not to mention……

Fauci thought of the Ebola case just now.

Although it is said that Ebola is not related to hemophilia, if you look carefully, they still have some similarities.

That is the destruction of the coagulation system mechanism.

Ebola virus is divided into several subspecies, among which the most virulent and common subspecies can cause fatal hemorrhage.

Patients infected with these viruses often die in a gruesome manner. The patient first suffers from internal bleeding, then continues to bleed from the seven orifices, and constantly vomits the necrotic tissue of the internal organs from the mouth, and finally dies due to extensive internal bleeding.

In laboratory tests, lymphopenia, severe thrombocytopenia, and elevated transaminase (AST>ALT) can be found in patients, and sometimes blood amylase also increased.

This means that the patient's immune system and blood coagulation system are both impaired, and the blood coagulation system is the more severely damaged one.

Therefore, the joint laboratory's research on the DNA expression of AHG-B globulin in organelles may find the possibility of treating hemorrhagic Ebola patients.

After all, in the blood, the most abundant cells are naturally red blood cells.

Mammals do not have the developed air-sac respiratory system like some archosaurs (dinosaurs, birds).

In order to adapt to the oxygen consumption required for high-speed exercise, mammals have undergone a series of magical changes in body structure.

Such as enlarged chest, reduced waist ribs, diaphragm, etc...

Finally, the breathing efficiency of the great mammals has finally managed to match that of the birds...

1/5.

Well, it's a sad story.

In order to compete with the archosaurs, mammals had to undergo further changes.

For example, muscles carry more myoglobin, which is why beef and mutton are red, while chicken and fish are white.

In addition, mammalian red blood cells also degenerate and lose their nuclei, becoming cells without a nucleus.

This makes the most widely distributed cells in the blood, and scientists have no way to use them by adjusting the DNA of the nucleus.

However, by using the method of implanting organelle DNA, it can regulate its originally degenerated secretion function.

At the same time, it can avoid potential risks and ethical issues caused by interfering with the main sequence DNA in the nucleus.

……

Thinking of this, Fauci couldn't help but look forward to it.

This is not just a disease like Ebola. Perhaps human beings have found a shortcut to overcome many incurable diseases.

Hopeful, Fauci opened his e-mail.

He couldn't wait to see if Jenny sent back the latest research progress.

Fauci plans to find time to go to that beautiful city next month to see the latest research results.

Even if possible, he also hopes to apply for an experimental grant from the higher authority, the National Institutes of Health, in order to speed up the progress of the experiment.

however……

Looking at the two emails sent by Zhang Zifan and Jenny one after the other in the mailbox, Fauci had a bad feeling in his heart.

(End of this chapter)