I Don’t Want to Win Lying Down

this day,

Academy of Sciences Institute of Biochemistry and Cell Biology.

Academician Zhong was very dissatisfied with the progress of the Department of Molecular Biology, but there was no news from Xu Mang for a long time, which made him a little desperate for a while. It seemed that the New Year was coming soon, but why did he feel so bad.

well...

Could it be that the project will be delayed for a year? Academician Zhong originally thought that finding Xu Mang would quickly solve the breakthrough problem in the field of gene editing, but the fact was the opposite, and he seemed to be in a predicament.

The phone call with Xu Mang should have been ten days ago. I'm afraid... I was tortured enough by this question.

At this time,

Academician Chu, an expert in bioinformatics, came to Academician Zhong's office. Seeing his helpless expression, he couldn't help but smiled wryly and said, Old Zhong...you've been frowning for almost three months, and it's almost time to go. Chinese New Year is coming, can you change your expression?

well...

I want to change too, but how? Academician Zhong sighed: The progress of the Molecular Biology Department is almost zero, and Xu Mang's situation is not very optimistic. I'm afraid it will be postponed indefinitely. It will be greatly reduced, at least in the field of gene editing, it will be reduced by about 20%.

No way.

It's too big...Some people objected. Old Chu sat opposite Academician Zhong, and said silently, But you are much better than Xu Mang, the collider project has been stuck, because of this project problem, Xu Mang He even resigned as a professor, his difficulties are much more serious than yours.

Hearing what Old Chu said, Academician Zhong smiled wryly and said, That's right...it's not about the difficulty level of a concept.

Say...

Have you contacted Xu Mang? Old Chu asked curiously: How about... you can call now and ask, I have a strong hunch that Xu Mang may have completed a breakthrough in the field of gene editing Question, when did you call Xu Mang before?

Ten days ago.

Ten days ago? Old Chu showed a trace of bitterness on his face: There is no such thing as ten days. If you ask now...it may give you an unexpected result, yes...hands-free!

Academician Zhong:? ? ?

what's the situation?

Why is Old Chu acting weird today?

no way,

Academician Zhong called Xu Mang, and the call was connected soon.

Hello?

Academician Zhong? Xu Mang's voice came out, with a touch of playfulness in his words, he said, New Year's is coming soon... I'll give you a New Year's greeting in advance, so I won't go...Magic City The distance from the capital is not so far.”

...

...

The two of them were very helpless, they seemed to be in a good mood, so should they ask next? After all, Chinese New Year is coming soon, it's not good to be a nuisance to others at this time, it's a bit unreasonable.

Academician Zhong hesitated, and wanted to ask about the progress several times, but he swallowed it back. After much deliberation... he gave up the plan to ask.

but,

Xu Mang brought it up.

Academician Zhong called me, do you want to ask a question about the progress? Xu Mang said with a smile, I've almost finished it...a rudimentary AI system has been developed and is currently being tested. I guess...it's almost time.

???

???

do...

Got it?

Isn't this too surprising?

Academician Zhong and Academician Chu glanced at each other in bewilderment, with expressions of shock and a little disbelief on each other's faces.

In my concept, I bypassed the problem of replacing the DNA fragment with the target sequence, and directly cut a DNA strand, and then the reverse enzyme was guided by the RNA strand to perform gene editing at the cut point. Xu Mang said seriously : Although it is still a CRISPR–Cas9 system, I have modified Cas9.

Bypass?

This... this idea is okay!

Academician Zhong hurriedly said, Can you be more specific?

Can!

First, a DNA strand is cut and the target sequence Y is inserted, then the original sequence is excised, another unedited DNA strand is cut, and finally the CRISPR system repairs the cut DNA strand.

In this way, the enzyme doesn't need to cut the double strand of DNA, so researchers don't have to rely on the cellular DNA repair system that they can't control to edit the cut DNA strand. Xu Mang paused, and said seriously: It means that with the help of a new editing The system can develop genetic disease problems associated with gene mutations.

for a while,

The two academicians were completely silent. What Xu Mang said was based on the existing gene editing tools, which could not be done at all.

correct!

I came up with another method the day before yesterday. Xu Mang said with a smile, Its accuracy is comparable to my editing tool system. This technology can directly replace bases without cutting the double strand of DNA through chemical methods. For example, replace T with A, and G with C.

The CRISPR–Cas9 gene editing system can't do this, but... Xu Mang sighed: This method can't solve the problem of polynucleotides, such as the translated Tay-Mongolian idiot symptom, which is It is caused by the wrong insertion of 4 DNA bases in the HEXA gene.

this...

It's just,

Too strong, right?

Hearing Xu Mang's introduction, the two bigwigs from the Academy of Sciences were so shocked that they couldn't speak, and they sat in their positions with blank faces.

Anyway...

My positioning for the new system is that it is flexible, simple, and able to realize a variety of gene editing functions. Xu Mang said seriously: A system composed of a variety of enzymes, including the improved Cas9 enzyme, can be edited in almost no time. Changing, deleting single bases, or inserting small stretches of DNA sequence without disrupting the double strand of DNA.

Academician Zhong took a deep breath and asked cautiously, Xu Mang...how long will it take to finish?

Before the new year.

Give me another five days, when I finish the test, I will give it to you... Xu Mang said with a smile, You can use AI to conduct a simulation test, modify it according to the test results, and then go to the laboratory for the final test .”

Anyway, it is to reduce your workload. After all, the future is an era of artificial intelligence. Xu Mang said helplessly, Academician Zhong... This is the result of my best efforts, if the result is still not satisfactory , I'm sorry... I really can't do anything later.

Not satisfied?

What a joke!

This was clearly completed beyond expectations!

What Xu Mang said is more advanced than any improved CRISPR-Cas9 system, because it does not rely on the cell's own repair system for gene editing.

No!

Professor Xu...if all of this becomes a reality, I can swear...your new system will definitely become the most advanced gene editing tool in the world. Academician Zhong said seriously: I'm not joking, this is already super Beyond any imagination.

Xu Mang opened his mouth, and said in a low voice, Academician Zhong... I have a request, can the constraints in the field of gene editing be strengthened in the future? I feel... a little worried, worried that future humans may not be real human.

I know what you're worried about.

It is true in this regard...our binding force is not enough, including a very serious mistake that occurred not long ago. Academician Zhong's tone was a little serious: I will propose relevant measures in the near future and implement them all within one year. .”

oh...

That's fine. Xu Mang said, I'll hang up first.

moment,

call disconnected,

However, the excitement is still lingering in Academician Zhong and Academician Chu's minds. It is impossible to imagine what they heard just now. Unexpectedly, Xu Mang has really achieved something in this field that the world has not done. He has broken through gene editing. Dilemma in the field.

Old Clock...

What should I do? Academician Chu smiled bitterly: Such a genius is actually engaged in physics... Are you angry?

well...

There is still a huge gap between our researchers and the world's top. Academician Zhong said helplessly: It's a pity...there is only one Xu Mang in this world. I really hope there are a few more. I can't imagine what will happen in the future.

One Xu Mang is enough...he is almost omnipotent. Academician Chu said with a smile, If you have difficulties, find Xu Mang. There is nothing wrong with this sentence!

...

at the same time,

A certain villa far away in Shanghai,

Xu Mang was sitting on the sofa, watching a boring TV series with Xiaoman. Speaking of which, this TV series is quite... very thought-provoking. It reflects the problems of modern families' education for their children, and it also reflects the problems that children face. Helplessness when studying under pressure.

husband?

You said... will our children be stupid in the future? Yang Xiaoman frowned and asked seriously: You are a great scientist and I am a great entrepreneur, but our children... The grades are always at the bottom of the school grade, so who will hold the parent-teacher meeting after this?

Xu Mang: (°ー°〃)

yes!

If it's very naughty, who will the parents go?

I dont go!

I won't go even if I'm killed... Xu Mang shook his head, and said seriously, I'm a great scientist, and I also have shame. Anyway... I won't go no matter what.

Yang Xiaoman is so angry, in fact, she doesn't want to embarrass herself, but two people must go to one, what should I do?

at last,

Subdued by force, Xu Mang became the first choice to hold the parents' meeting.

actually...

It doesn't have to be the bottom of the test, it may be the number one. Xu Mang gently hugged Xiaoman into his arms, leaned into her ear and said, I'll ask you a question, in a certain potential field The problem of the absorption cross section of bound electrons for planar light waves.

Excuse me, if the electron is bound to the base by the following potential...

Before Xu Mang finished speaking,

Yang Xiaoman glared viciously, and said angrily: Get lost! I won't listen, old lady!

hey-hey...

No, right? Xu Mang said with a smile: The problem has been found, but you are too stupid, dragging down my smart and powerful genes.

Yang Xiaoman: (*￣︿￣)

After a family education, Xu Mang hugged Xiaoman with a little grievance on his face.

But sure,

Xu Yang and Xu Man are already invincible in fighting.

...

this day,

The Xuman system No. 2 is completed, but there is a lack of real data from the laboratory.

Hello?

Academician Zhong.

It has been completed, but... I would like to ask you to lead the entire team to help me verify the correctness of the AI ​​simulation!