I Have a Research Support System

At 8:30 in the morning, on the school bus, Xu Qiu and Han Jiaying sat side by side, chatting in whispers.

Due to the different division of labour, they are usually separated in two campuses, get together less often, and spend more time together. The two cherish the rare time together.

However, compared to real couples in different places, the situation is much better. At least every morning and evening, Xu Qiu and Han Jiaying can get together.

Forty minutes later, the school bus slowly drove into the Zhangjiang campus.

I was still slightly affected by the aftermath of the rush hour. If it was the school bus at 9 or 10 am, it would take about half an hour to get there.

After getting off the car, they first went to the drug warehouse to get 5 shuttle-shaped PTFE stirrers, 10 packs of disposable PE gloves, 4 boxes of disposable latex gloves, and a pack of 19-hole rubber stoppers. Consumables, go to Microelectronics Building.

Entering room A501 and putting down the experimental consumables, Han Jiaying casually asked:

Brother came here today, mainly for the microwave reactor.

No. Xu Qiu shook his head.

Hmm... Han Jiaying tilted her head and asked curiously:

Is there something else, I don't know why, is it a response, or...

The main reason is to see you. Xu Qiurou said.

Ah~ Han Jiaying let out a soft cry, blushing and said in a low voice, Brother, what's going on today...

The atmosphere in the room instantly turned pink...

However, this atmosphere did not last long.

A few minutes later, Chen Wanqing suddenly opened the door and came in. Seeing the scene in the room, she sighed softly, Hey, I just had breakfast, and I was asked to add another meal, sorry to bother you.

Afterwards, she pretended she didn't see anything, stepped back with narrowed eyes, closed the door, knocked three times symbolically, and then opened the door again to come in.

At this time, Xu Qiu and Han Jiaying had returned to normal, and their clothes were barely tidy, but the junior girl's face was still bright red.

The three tacitly did not mention what happened just now, and stared at each other for a while.

What time will they come over in the afternoon? Chen Wanqing took the initiative to break the silence.

Xu Qiu was stunned for a moment, and then realized that the senior sister was talking about the microwave reactor, and responded, It's about one o'clock. Teacher Wei sent me a message this morning.

Speaking of it, Xu Qiu was a little surprised when he received the news. Mr. Wei was on the plane this afternoon, and he was still thinking about the laboratory in the morning, and he asked, Take a few photos after the equipment is installed, and I will look at it when I get off the plane.

Hmm... Chen Wanqing thought for a while, and said, One o'clock in the afternoon is okay. I need pyridine for today's reaction, so wait until the equipment is installed, and you can submit after processing the reaction.

Is it the synthesis of CH1, the final product of A-D-A materials, under the new route? Xu Qiu asked.

That's right. Chen Wanqing nodded slightly.

Senior sister's progress is pretty fast. Xu Qiu praised casually.

After all, the reaction steps have been reduced by so many steps. Chen Wanqing smiled.

Then I have to speed up the progress. Today I have to cast two responses and pass two pillars, Han Jiaying interjected, then turned to look at Xu Qiu, and asked tentatively, Brother, help me?

Okay, then I'll vote for you. Xu Qiu agreed without hesitation. After all, he has come here, and he really doesn't have anything else to do. He can't make a day.

That's great, Han Jiaying chuckled, and continued, Today's two reactions are boronate reactions of B4T and B3T.

If I remember correctly, this step of reaction is the second step in the whole reaction chain. Xu Qiu rubbed his chin and said in a strange tone, It's already Thursday, junior, did you catch fish a few days ago?

Of course not, Han Jiaying shook her head hurriedly, explaining: Today, I have to go through two reactions on the column, which is the final product of my second-generation 3D-PDI. The estimated yield is more than 200 mg.

As for today's batch of reactions... After a pause, Han Jiaying continued: My idea is that when developing the third-generation 3D-PDI materials in the future, boronated B4T and B3T units are also needed, so I plan to synthesize more Some preparations.

I understand, Xu Qiu said with a smile, It just so happens that this is a new reaction to me, so let's switch identities this time, and you can teach me.

Okay. Han Jiaying raised her eyebrows, she seemed very happy, she opened the experiment notebook, found the experiment records a few days ago, and copied the experiment conditions on a sticky note. Because it is a reaction that has been successfully synthesized before, there is no need to recalculate the product feeding ratio.

Chen Wanqing looked at the figures of Xu Qiu and Han Jiaying in the room, and pursed her lips.

She has read all the recent literature in the field of organic photovoltaics, and there is nothing else to do, so she put on her headphones silently and began to follow the drama, digesting it by the way.

If you don't need to write a review, you still have a lot of free time to do synthesis in Zhangjiang, compared to making devices in Handan.

However, it is also really busy to do organic synthesis. It is common to work continuously for three or four hours after the post-treatment of small molecule reactions and columns. For devices, it is rare to work continuously. During the process of cleaning substrates, annealing, and evaporation There are plenty of gaps to rest.

Xu Qiu and Han Jiaying made preparations before the experiment and entered the A502 laboratory together.

The school girl turned into the role of a mentor and began to explain:

The raw materials are B4T/B3T and pinacol biborate, the catalyst is metal iridium catalyst, di-tert-butylbipyridine, and the solvent is n-heptane...

The reaction temperature is 120 degrees Celsius, and the reaction time is 24 hours. The reaction process needs to be anhydrous and oxygen-free, and it must be protected by a nitrogen balloon...

...The above are all the precautions. Han Jiaying put her hands on her hips and said old-fashionedly: You've lost your studies, brother.

It's useless to study. If you don't become a tutor at this level, you will be inferior. Xu Qiu cooperated.

It has been a long time since he was supervised by others to do experiments, and he experienced it again today, especially when the instructor is still a junior, it really feels strange.

The two looked at each other for a few seconds and then laughed.

After a while, Xu Qiu reached out and patted Han Jiaying's shoulder, and said, Have enough of being a teacher, go and purify the product, there's a lot of experimental work today. He put on his gloves not long ago, I haven't touched anything in the laboratory, so it is clean, and it is separated by a lab coat.

Yeah, okay~ Han Jiaying nodded and ran away happily.

Xu Qiu transferred the necessary medicines from the reagent cabinet and refrigerator to the fume hood.

The raw materials and products of this reaction are not the same as the molecular structure of the previously synthesized PDI series, so the properties will be quite different.

However, this is not a big problem for him. When he designed the reaction, he consulted many literatures on the introduction of borate esters, but the molecular structure he designed was relatively simple, and he could directly buy the corresponding commercial Raw materials, there is no self-synthesis.

Xu Qiu glanced at the bottles of catalysts, one of which was marked with {Ir(OMe)Cod}2, which had a complex structure and was a coordination compound of iridium, and COD was the brand name; the other was di-tert-butylbipyridine, abbreviated as dtbpy, in terms of function, he guessed that it is probably something like a ligand, and it can also be regarded as a part of the catalyst.

This combination is a bit like the metal palladium catalyst used in the previous Stille and Suzuki reactions.

In fact, many transition metal elements on the periodic table have good catalytic performance.

Xu Qiu continued to check the other reagents.

The molecular structure of biboronic acid pinacol ester is quite interesting, and the two borate units are connected together head-to-head.

In his mind, he instantly recalled the situation during the reaction. One unit of borate unit binds to a reaction site on B3T/B4T, and the other borate unit falls off. In order to obtain three-substituted and four-substituted products, obviously, This component should be in excess.

Xu Qiu glanced at the junior girl's sticky note, and it was indeed consistent with his speculation.

Finally there is the solvent, n-heptane, which is not a commonly used solvent.

He roughly remembered that the common solvents used in the reaction of introducing borate esters were DMF, DMSO, dioxane, methyl tert-butyl ether, etc., but he didn't mean to replace them. The school girl has already figured out the conditions, so just use them directly .

When Xu Qiu used n-heptane solvent for the first time, he briefly read the MSDS manual and learned that its boiling point is close to 100 degrees Celsius. The steam has anesthetic and irritating effects. Acute inhalation of the steam can cause dizziness, nausea, anorexia, and euphoria and staggering gait, and even loss of consciousness and stupor.

The euphoria made him think of gasoline. Speaking of which, he always thought that the smell of gasoline was quite pleasant, and the main component of gasoline was a mixture of aliphatic hydrocarbons and cycloalkanes with between five and twelve carbons. Alkanes are straight-chain saturated aliphatic hydrocarbons with seven carbon atoms.

Could it be that there is heptane in it?

After confirming all the reagents, Xu Qiu started the experiment.

Solvent redistilled, n-heptane.

Prepare a clean two-neck flask, a magnetic stirring bar, a condenser tube, and use a three-way valve and a balloon as a nitrogen balloon.

In a round bottom flask, add {Ir(OMe)Cod}2, di-tert-butylbipyridyl, pinacol biborate, and n-heptane solvent in proportion, and stir vigorously until it turns dark red, as a catalyst stock solution.

Mix the B3T/B4T raw material and the catalyst stock solution in proportion, transfer it to a reaction bottle, connect a nitrogen balloon, a condenser tube, three pumps and three rows, connect condensed water, and rapidly raise the temperature to 120 degrees Celsius, and cover the reaction bottle with aluminum foil.

Done, call it a day.

For the two reactions, the first three steps are the same, and there is only a difference in the fourth step, which saves a lot of time.

It took less than an hour to complete the response, Xu Qiu turned to look at Han Jiaying, saw that she was still passing the first pillar, but it was nearing the end, so she walked over to help her spin the product.

Before lunch, the two successfully completed today's experimental work and gained a lot.

Senior sister also gained a lot, but in the spiritual world.

She followed two episodes of the drama that promoted the main theme in the morning, and she felt that she had sublimated a lot.