I Have a Research Support System

After lunch, in the afternoon Xu Qiu continued to organize the third and fourth categories of drugs in the laboratory.

Because these medicines had been opened, he was extra careful when sorting them out.

Zhang Jiang's laboratory mainly does organic experiments, and generally uses various organic solvents.

Duan Yun and Tian Qing also did some inorganic reactions before, so some inorganic acids, bases, and salts were also involved.

In addition, there are some other miscellaneous materials,

Organic solvents are relatively easy to handle.

The approximate opening date can be deduced from the production batch number on the reagent bottle, and the remaining solution volume can be seen through the glass of the bottle.

Then according to this information, they are divided into three or four categories of drugs, the third category is packed and ready to be taken away, and the fourth category is left as waste liquid for disposal.

Of course, the criteria for judging the three and four categories of drugs previously designated are not completely fixed.

If it is a four-liter or five-liter solvent, even if the remaining amount is less than half, for example, there is about one liter of solvent left, Xu Qiu will classify them into three categories.

After all, there is a lot left, and it would be too wasteful to treat it directly as waste liquid.

In addition, there are some special substances in the solvent, such as pyridine with a relatively strong taste.

When Xu Qiu took inventory, he found that there were two unused bottles of 500ml pyridine remaining in the laboratory, with 1/3 of one bottle remaining and about 2/3 of the other bottle remaining.

He thought about it, and decided to take them all away. In theory, pyridine is an alkaline substance, which can be neutralized with acidic substances such as hydrochloric acid to form pyridine salts, but in the actual processing process, there will definitely be a large amount of pyridine. The steam escapes, and the whole laboratory will be smelled by then...

But it is not appropriate to take it away without any treatment, because the sealing effect of the bottle cap of the reagent bottle is limited. After opening, even if there is a bottle cap to block, some solvent molecules will escape, and people can still faint About the smell.

Therefore, Xu Qiu used adhesive tape to wrap the mouth of the reagent bottle containing pyridine several times to ensure that too much pyridine would not escape during transportation.

After dealing with organic solvents, Xu Qiu continued to deal with inorganic acids, bases, and salts.

Inorganic alkalis and salts are uniformly placed in a reagent cabinet, and they are relatively easy to handle.

Because most of them exist in the state of solid powder or crystal, they are almost non-volatile, and there is no harm as long as they are not directly contacted or swallowed.

The types are also relatively rich, adding up to a total of more than 30 kinds.

Among them, potassium carbonate and sodium carbonate are used for Suzuki reaction, sodium thiosulfate is used for iodine treatment, sodium hydroxide is used for preparing alkali tank, etc., potassium fluoride is used for fluorination reaction...

Most of these reagents are bought from Sinopharm, so the packaging is relatively consistent, white opaque square plastic bottles, which can be directly stacked together neatly. Xu Qiu didn't bother to disassemble and inspect them one by one, so he directly divided them into three categories and took them all away.

The main advantage of Sinopharm is that the price is relatively cheap, 500 grams is about 100 yuan, and the purity is not low, which can reach the level of chemical purity. Most of the reagents used in the reaction are chemically pure enough, and there is no need to forcefully pursue the purity of how many 9s.

Acids are also placed in a reagent cabinet, and they are a little more troublesome to deal with.

The acids currently stored in the laboratory include perchloric acid, concentrated hydrochloric acid, concentrated sulfuric acid, concentrated nitric acid, etc., all of which have been opened.

The label of the reagent bottle containing the acid has been corroded and turned yellow, and there is a circle of yellow marks on the bottom of the reagent cabinet.

Moreover, after opening the reagent cabinet, a sour smell hits the face.

If it is explained in a scientific way, it is that when acid molecules are inhaled into the nasal cavity, they are ionized to generate hydrogen ions, which are sensed by olfactory cells (probably combined with a certain protein), and then inform the brain through electrical signals:

There is acid nearby, it's dangerous.

Among the several acids currently in the laboratory, perchloric acid is the most acidic of the inorganic oxyacids, ranking first among the six inorganic strong acids.

Xu Qiu had never been exposed to perchloric acid in the experiment, maybe Duan Yun or Tian Qing had used it before.

Several other acids are also strong acids, and concentrated hydrochloric acid is highly volatile and irritating;

Sulfuric acid and nitric acid have strong oxidizing properties, and when their concentration reaches a certain level, they will fume during use. Therefore, high-concentration sulfuric acid and nitric acid are also called oleum and fuming nitric acid.

Although they are also dubbed as fuming hats, there are still certain differences between sulfuric acid and nitric acid.

Fuming nitric acid is an aqueous solution with a nitric acid content of 90%-97.5%, which absorbs moisture in the air and fumes violently.

Fuming sulfuric acid is a sulfuric acid solution of sulfur trioxide, which has strong water absorption. When it is exposed to the air, the volatilized sulfur trioxide and water vapor in the air will form fine dew droplets of sulfuric acid and smoke. Nicotinic acid can be considered as sulfuric acid in concentrations greater than 100%.

Although the laboratory is full of strong acid, Xu Qiu is not in a panic.

Because their toxicity is average, as long as they don't directly get on the body or clothing, it's not a big problem.

In fact, except for hydrofluoric acid, most of the inorganic acids used in the laboratory are not very dangerous as long as they are handled properly.

The hydrogen fluoride gas that will be volatilized during the use of hydrofluoric acid can be absorbed through the human skin and cause poisoning.

Gaseous toxic substances are hard to detect, and there is no effective antidote.

If you only rely on the body's own metabolism to detoxify, it is estimated that you will have to wait until the end of the monkey year, so the degree of harm is relatively high.

After inspecting the acid reagent cabinet, Xu Qiu found that there were not many acids left, and most of them had been used for more than a year, so the concentration may have been inaccurate.

Therefore, Xu Qiu planned to classify them into four categories and dispose of them directly as waste liquid, and then go to Jiangwan Laboratory to replace them with new ones.

The school’s waste liquid recycling department generally only accepts organic solvents. These acids, alkalis, strong oxidizing agents or strong reducing agents are not recycled and need to be processed by the laboratory.

At this time, you can contact a professional laboratory waste treatment company.

However, any project related to scientific research will have a very high premium.

As far as Zhang Jiang's laboratory has only a few liters of acidic waste liquid, it is not worth spending a lot of money to ask a specialized company to dispose of it. You can handle it yourself.

The treatment method is not difficult, that is, first add water to dilute the acid solution, and then use the method of acid-base neutralization to convert the acid waste solution into a harmless inorganic salt solution, and finally it can be directly discharged into the sewer.

Of course, there is still a certain degree of danger in this work, so Xu Qiu decided to deal with it himself after sorting out all the reagents.

Finally, it was the turn of other miscellaneous reagents and materials.

There are quite a lot of types, and there are hundreds of them.

Similar to how organic solvents, inorganic acids, alkalis, and salts were treated before, Xu Qiu divided them into Class III and Class IV drugs based on comprehensive considerations such as reagent value, use time, and danger.

During the sorting process, Xu Qiu discovered that there were many special materials.

Sodium block, usually stored in kerosene, when used, use tweezers to pinch it out, and then cut a small piece with a knife to remove the water in the solvent.

The activity of sodium is much lower than that of potassium and cesium of the same family. When sodium is directly exposed to the air, it usually does not spontaneously ignite, and an oxide layer will form on the surface to protect the sodium inside.

As long as you don't kill yourself, such as throwing a large amount of sodium into a large amount of acid or water, the danger is average.

And if it is cesium, after touching the air, it will explode due to violent reaction after brushing it.

In addition, sodium sounds very high-end, but it is actually a common metal. Industrial-grade sodium is not expensive, and the unit price is about 2W.

The unit is not grams, nor kilograms, but tons.

Even copper is more expensive than sodium, and the price of a ton of copper is about 5W.

Not to mention precious metals such as silver, gold, platinum and palladium.

For liquid bromine, in order to prevent decomposition, the bottles are opaque, tightly covered, and sealed with water and liquid. The price is not expensive, about 3W5 per ton.

Transition metal catalysts, mainly palladium catalysts, and the corresponding ligands usually need to be kept away from light and low temperature, and the price is not cheap. Xu Qiu also classifies them as a class of drugs and puts them together with the previously sorted monomers.

Hydrazine hydrate, which Duan Yun used before, is an aqueous solution of hydrazine.

Hydrazine is a substance obtained by directly connecting two amino groups. It is also called hydrazine. It is alkaline and a strong reducing agent and is used in rocket fuel.

Now that Duan Yun is leaving, no one will use this material, so Xu Qiu plans to dispose of it directly by neutralizing it.

n-Butyllithium, chemically active, spontaneously ignites directly when it encounters air.

The n-butyllithium in the laboratory is dissolved in tetrahydrofuran, the concentration is not high, and the remaining amount is not large. It can be directly drawn out with a syringe, and then disposed of with ethanol.

Tin reagents include trimethyltin chloride, tributyltin chloride, etc. The former has higher reactivity than the latter, but its toxicity is stronger than the latter, and it is a highly toxic substance.

In the laboratory, in order to pursue the reaction yield, trimethyltin chloride is used, which is mainly used when Han Jiaying synthesizes the polymer donor process and designs the monomer unit by herself.

Of course, the school girls are usually exposed to tin reagents of several hundred milligrams and several grams, and the risk is relatively low.

Some research groups mainly study tin reagents, and often tens to hundreds of grams of tin reagents are exposed, which is quite miserable, and the hairline of almost everyone is moved forward.

Malononitrile, an organic cyanide, is a raw material for introducing cyano groups that must be used in the synthesis of ITIC terminal A unit ICIN, and its toxicity should be slightly lower than that of tin reagents.

Now the dosage in the laboratory is still quite large, mainly Wu Shengnan is using it.

There is no way to avoid this. If you want to do scientific research, you must make sacrifices. Xu Qiu can only hope that the postdoctoral seniors will pay more attention to their own health and safety.

In addition, there are many unclaimed materials contained in glass bottles without labels or markings. Xu Qiutongtong classifies them as four types of drugs and treats them as solid waste.

The school does not have any special recycling places for solid waste disposal, and there are no guidance methods.

Most laboratories throw solid waste together with other experimental waste directly into the waste bins for experimental waste. As for whether it will cause any environmental or personal hazards, it all depends on the self-consciousness of each laboratory to see if they have put the toxic The matter is cleaned up...

Of course, as far as the amount used in the laboratory is concerned, even if there are residues that have not been cleaned up, they are generally at the level of milligrams or a few grams, and will not cause too much pollution to the environment.

After sorting out the four types of medicines, Xu Qiu took a look at the progress of Wu Shengnan's side, which was slower than him and his junior, about 50% completed.

Because the post-doctoral senior sister not only needs to be responsible for making cartons, but also needs to disassemble and assemble all the instruments and equipment and pack them, so the workload is a bit bigger.

After that, Xu Qiu asked Han Jiaying to take a taxi to the Jiangwan campus with a box containing a class of drugs, while he returned to the office to sort out the list of hazardous chemicals to be transported.

In addition to the part that the school girl moved in advance, there are a total of 127 other drugs to be moved. Xu Qiu's task is to compare these 127 drugs with the 2828 types of hazardous chemicals mentioned in the Catalogue of Hazardous Chemicals. Find out the hazardous chemicals among them, and then report them to the departments.

The department provides a statistical template in the format of serial number, reagent name (Chinese name), original bottle specification, quantity, hazardous nature (such as corrosion, flammable, explosive, etc.), moving out of campus-building-room, moving into campus-building- The room, the person in charge of the research group, the mobile phone of the person in charge of the research group, the contact person of the research group, and the mobile phone of the contact person.

Overall, it's rather cumbersome.

After more than two hours, Xu Qiu kept pressing the shortcut keys such as Ctrl+C/V/F/H, and his hands were almost cramp. Finally, he sorted out the list of hazardous chemicals to be transported and reported it to the department for review by email.

After screening, a total of 62 of the 127 drugs were classified as hazardous chemicals.

To Xu Qiu's surprise, even ethanol is considered a hazardous chemical because it is flammable and irritating...

On the way, Han Jiaying successfully arrived at the laboratory of Jiangwan Campus with a class of drugs, and sent a message to report safety.

On the other hand, Wu Shengnan also took Sun Wo, Yan Hu and Yin Houlang to complete the packaging of Zhang Jiang's laboratory equipment.

They packed a total of twelve large cardboard boxes, numbered the boxes with a marker pen, and marked the types of instruments inside.

Four of the boxes are glass instruments, which are placed in a sandwich-making method, that is, first spread two layers of bubble wrap, then put a layer of glass instruments, and then lay two layers of bubble wrap...continuous cycle until full.

The other eight boxes contain various instruments, equipment, and some small iron clips and other miscellaneous gadgets.

All large instruments that can be disassembled are disassembled. For example, the originally large rotary evaporator is now directly disassembled into eight pieces, divided into small parts, and placed separately.

Before and after the disassembly and assembly of the instrument, in order to prevent forgetting the disassembly method, Wu Shengnan and the others took photos according to Xu Qiu's instructions.

Otherwise, it would be embarrassing if the instrument went to Jiangwan and found that it couldn't be installed back.

There are also some large instruments that cannot be disassembled, such as ovens, which are not packed in boxes, and the moving company can be directly responsible for moving them.

In addition, nitrogen cylinders cannot be boxed, but you only need to contact the school’s drug warehouse for recycling the cylinders, and you don’t need to carry them by yourself.

Xu Qiu carefully inspected each box and took photos to keep the bottom. In the end, everyone sealed the mouths of all the boxes with sealing tape.

Since then, the preliminary preparations for the relocation of Zhang Jiang's laboratory have been basically completed.