I really don't want to lie down and win

"Can we still make a breakthrough?" Xu Mang scratched his head, feeling a little confused for a moment. According to the historical process, it is possible to make a breakthrough. After all, CRISPR technology was discovered in the early 90s, and it was not until seven years later. It has become the most popular gene editing tool in fields such as human biology, agriculture and microbiology.

but...

One thing Xu Mang wanted to complain about was that the United States was so shameless that it secretly obtained the first patent authorization of CRISPR, which meant that it might be illegal to use CRISPR technology in the future.

Finally, it was five o'clock in the afternoon.

When Yang Xiaoman came home from get off work, he saw Xu Mang lying motionless on the sofa. It was not surprising that her husband was paralyzed to death every now and then. Have you been lying on the sofa all day?"

"No."

"It's only been half a day..." Xu Mang said with a smile: "Xiaoman... I went to meet the second grandfather in the morning, and he introduced a person to me, the person in charge of the Institute of Biochemistry and Cell Biology of the Academy of Sciences." Academician Renzhong."

Yang Xiaoman frowned, and asked calmly: "Did I ask you for help again?"

"Ok!"

"Second Grandpa's friend, but I really want to challenge it." Xu Mang said seriously: "This is about the research direction in the field of gene editing, looking for a new editing tool system that is better than the existing CRISPR system."

Hearing Xu Mang's words, Yang Xiaoman's face was full of confusion, and he couldn't understand what he was talking about at all. This guy's field has become wider and wider, and he has begun to involve the field of gene editing...

"Ugh?"

"idiot?"

"Are you a physics student?" Yang Xiaoman sat next to Xu Mang, and asked curiously: "I found that your partiality is getting worse and worse. You are a theoretical physicist, can you do yourself well?" your job?"

"Ugh..."

"Those who are able work harder." Xu Mang said with a smile, "Is this the truth?"

"Fool!"

Yang Xiaoman rolled her eyes, and asked calmly: "What do you want to eat tonight? I'll make it for you? Do you want braised pork? How about... how about steamed sea bass?"

"casual."

"As long as it's made by you, I love to eat it." Xu Mang said casually, but it turned out that such an absent-minded sentence made Yang Xiaoman run into the kitchen, even the heavy oily smoke couldn't stop Xu Mang cook.

The next day,

Xu Mang was lying on the bed. After thinking about it all night, Xu Mang decided to contribute his own strength in the field of gene editing, trying to find new possibilities, but most likely it would be to make some changes in the CRISPR system.

"Hey?"

"Second Grandpa..." Xu Mang said with a smile, "Guess what I want to do?"

"..."

"What do you want to do?" Second Grandpa said angrily, "By the way, how are you thinking?"

"almost."

"I'm going to try it." Xu Mang said seriously, "This is a very interesting challenge, and I like challenges, otherwise I wouldn't have married Xiaoman."

The second grandfather's tone suddenly became a little serious, and he said to Xu Mang, "Xu Mang...Are you sure you can do it? This is not a joke. Once something goes wrong, the consequences will be disastrous...Do you want to stop thinking about it?"

"no need!"

"I've already considered it." Xu Mang said, "Accept the challenge!"

Then,

The two talked about the trivial matters in life, and then hung up in a hurry.

The second grandfather took the phone and hurriedly called his old friend, Academician Zhong. He said that he worked as hard as Xu Mang did. He got off the plane early in the morning and went back at night.

"Hey?"

"Old clock!"

"Xu Mang agreed." Second Grandpa said, "Relax."

......

Chapter 735 Auntie, wait a minute! (2/3)

Beijing,

Academy of Sciences Institute of Biochemistry and Cell Biology.

An accident two months ago cast an indelible shadow here. Although there were no casualties, it caused irreparable economic losses. Although Huaguo is already a world-recognized leader in the field of CRISPR Cas9 gene editing , but this technique still has serious flaws.

How to make up for this defect has become a task for the Institute of Biochemistry and Cell Biology of the Academy of Sciences, although the CRISPR Cas9 gene editing technology has quickly become the most popular technology in life sciences due to its simplicity, efficiency and diversity.

Especially in gene therapy related to human diseases, it is hailed as one of the most potentially transformative innovations in modern human medicine, but behind the success is often the accumulation of failures. The accident two months ago was the last good description.

a certain department,

Silence has always shrouded this office. A dozen top researchers in the industry are having a headache for upgrading the CRISPR Cas9 gene editing technology. A whole month has passed without any gains.

For the research on clustered short repeat sequences at regular intervals, many people present are elite figures, but how to upgrade has stumped everyone, many of whom are doctors.

at first,

Everyone's goal is great, to establish an existence beyond the CRISPR system, but with continuous in-depth research, it is gradually discovered that the cruelty of reality has surpassed everyone's imagination. It is impossible for the CRISPR system to be surpassed at this stage. Fine optimization is carried out on the basis of the original.

However, the CRISPR system has been developed from the 90s to the present, and has been upgraded by countless biological scientists. It has reached the point where it can no longer be optimized. At present...the CRISPR system has entered a bottleneck period. A new theory will do.

Like physics, the span from classical physics to modern physics is hundreds of years, and from modern physics to new physics is still an unknown, while biology has just undergone a huge revolution, and when the next revolution will start is as unknown as physics.

"Ugh..."

"It's so difficult!" A doctor in the office sighed, and his words were full of helplessness: "The whole world knows that the main challenge in the standard CRISPR-Cas9 system is to reduce the probability of off-target, but who can do it? Even if it is done ...is equivalent to borrowing the shell of the CRISPR–Cas9 system, and the content inside will change.”

"Then what are you going to do?" The frowning middle-aged man sitting next to him said with a wry smile: "If this problem is not resolved, we may be greatly reduced in funding, after all, this matter has left too much shadow. "

For a time,

Helpless emotions flooded the hearts of everyone present. This problem was not a sporadic difficulty. Unless there was a genius like Xu Mang, there was no way to succeed.

Xu Mang?

Many people thought of what happened just a few days ago. Regarding the artificial intelligence that predicts the three-dimensional structure of proteins from amino acid sequences, it is said that if Professor Xu Mang is asked to develop a similar AI, it can simulate the modification of target sites.

"Ugh?"

"Do you think... if Professor Xu Mang suddenly designs a gene-editing AI one day, will there be a world-class biological revolution?" The doctor asked curiously: "I think it is possible... at present, in terms of protein structure , has caused a huge response.”