Ultra-Dimensional Technology Era

"Studying Cancer"

"almost."

After a long silence, Huo Yimin nodded: "I agree."

Fang Ge, who was in a high mood, rushed back to the laboratory immediately, and Huo Yimin, who was driving an old Buick, had no intention of repenting, and followed the electric off-road vehicle all the way.

……

Lin Sha, who was busy with the experiment, saw Fang Ge rushing in, and asked in surprise, "Didn't you say you were going to take a break? Why did you come back after only half a day?"

Fang Ge said excitedly while wearing protective clothing: "I discovered a new idea, cancer cells, there is no mistake, they are cancer cells."

"Cancer" Lin Sha was stunned, why didn't I think of it

In the human body, apart from cardiomyocytes, hematopoietic stem cells, and immune T cells, the really strong ones are cancer cells.

This kind of cells can even break through the limit of life and realize alternative immortality.

Huo Yimin, who was wearing the patient's clothes, lay quietly on the hospital bed. Fang Ge took several researchers to extract some cancer cells from his liver and lungs.

"Mr. Huo, if you need anything at the base, or if you want to go outside, you can tell Uncle Li."

"I will." Huo Yimin was very calm, maybe death was approaching, but he was relieved instead.

After extracting the cancer cells.

Fang Ge immediately organized personnel to cultivate cancer cells, and then prepared to do experiments.

And Wen Kehan ​​also made a breakthrough discovery. He screened out a hydrocarbon sulfide compound, combined with X serum, and after fusing to the cells, a very slight brain wave induction phenomenon appeared.

Everything is difficult at the beginning, with this slight brain wave induction, it finally has a beginning.

Rows of petri dishes were filled with cultured cancer cells. After the researchers injected new brain wave sensors, they found that these cancer cells were indeed very powerful.

"Inject, X serum minimum standard concentration." Lin Sha ordered.

"Ok."

Lin Sha, Fang Ge, Jiang Tiansheng and others were very nervous about the inspection screen of the electron microscope.

However, there is no minimum concentration for normal cells to die, so naturally they cannot kill cancer cells. Instead, after being injected with X serum, the cancer cells become more active.

Fang Ge and Lin Sha looked at each other, and they both saw surprise in each other's eyes.

"Increase the concentration by one level." Lin Sha continued to instruct the researcher.

"Ok."

The serum concentration of X increased step by step, but the cancer cells were still very tenacious in resisting the invasion.

Up to a concentration of 0.65%, the cancer cells never could withstand the attack of X serum, collapsed and died.

This concentration is 34 times higher than the previous safe concentration.

Jiang Tiansheng, who was in charge of testing the brain wave sensing function of cancer cells, ran over excitedly with the test report: "Successful! We succeeded!"

Fang Ge, who took the report, looked at the above data with Lin Sha. In the 12 groups of cancer cell culture dishes, obvious data of brain wave induction were detected.

Among them, the eighth group of data has obvious peaks. Compared with the first detection of brain wave data, the two are like the difference between static electricity and lightning.

The experiment has made a breakthrough, and it is one step closer to the biological computer.

Chapter 198 Cell Chip

Inside a petri dish, a small group of translucent cells with a hint of light green was trembling non-stop.

That's right, it's trembling, trembling visible to the naked eye.

"It's amazing." Lin Sha approached the petri dish curiously, and found that the cells and tissues inside were trembling even more.

Fang Ge thought for a while, then guessed: "Maybe our brain waves are affecting it."

The excited Jiang Tiansheng nodded:

"It is indeed our brain waves that are affecting, which proves that cancer cells have been successfully endowed with brain wave-sensing protein components, but now we have not endowed filters and cannot receive brain waves in a directional way."

Fang Ge was very happy. Although the cell tissue in the petri dish was like a newborn baby, this represented a new stage of research and development. Then she smiled and said:

"Step by step, we have now taken a critical step towards success."

"Xiao Ge makes sense." After Lin Sha got acquainted with Fang Ge, she didn't have the same sense of distance as before.

What's more, Fang Ge's level is really good, not only his ideas are wild and unconstrained, but his biochemical foundation is very solid.

As expected, birds of a feather flock together and people are divided into groups. To be a student of Academician Huang is extraordinary.

After the brainwave sensing protein component made breakthrough progress, Fang Ge decided to split into two groups. Jiang Tiansheng was in charge of continuing to improve the brainwave sensing protein component, while she, Lin Sha, and Wen Kehan ​​contributed to the second component—the brainwave feedback protein component. attack.

With the sensing part, brain waves can be received; and with the feedback part, brain waves can be released.

The two are indispensable, which means that the U disk must be able to store information and must also be able to read information, and neither will work without one.

With the experience in developing brainwave-sensing protein components, Lin Sha, Fang Ge, and Wen Kehan ​​followed suit.

Using cancer cells as the substrate, injecting brain wave feedback element and X serum, a set of most suitable brain wave feedback protein parts was developed in less than two days.

And the next step is the general direction that those international colleagues are doing, protein logic gates (transistors), and protein logic devices (large-scale integrated circuits) integrated by protein logic gates.

The basic input to protein circuits is controlled by CIPHR (cooperatively induced protein heterodimerization).

The so-called CIPHR is a polymer of two different proteins, each of which corresponds to an input at a specific position, and different combinations are equivalent to 1 at different positions in the circuit.

The logic gates of CIPHR are portable, which also means that we can use logic gates to control different biological functions.

Fang Ge and Lin Sha designed four pairs of heterodimer modules and built two logic gates with different control functions.

Using cancer cells as the basic framework, a protein is embedded on the corresponding nano-site, and X serum is injected as fusion coordination, and whether the logic gate is opened or not is tested by in vitro translation and monitoring of luminescence.

If a heterodimer is used, as long as an entry (1) results in an inhibition (0), which is equivalent to a NOT gate.

If protein monomers are used, as long as any protein enters (1), it will destroy the original TALE-KRAB binding and cancel the inhibition (1), thus realizing the function of the OR gate.

NOT and OR gates were used to control the expression of TIM3 protein, detected by flow cytometry.

The above is only the case of two inputs. It is similar if the input is increased to three, but more dimers are used, and more proteins are used inside the logic gate.

The test results show that the protein logic gate can accept their control, but because the brain wave feedback component and sensing component are not assembled, the protein logic gate is controlled slowly and the response is relatively slow.