With the current success, T cells can automatically destroy the corresponding cancer cells in a specific container in the laboratory.
so as to achieve a clear effect.
The human body is a complex individual. After T cells enter the human body, there are too many uncertain factors.
Clinical observation is needed to see if it can completely eliminate cancer cells.
At the same time, it is also necessary to observe whether T cells will damage other cells while destroying cancer cells.
Unnecessary harm to patients.
All of these require clinical trials before conclusions can be drawn.
Although there are many uncertainties.
Xue Zhongnian still believes that the success rate of car-T cell therapy clinical trials is at least 70%.
"So now is not the time to celebrate." Chen Siyi said with a serious attitude: "I think the next step is to apply to the superior, and after the application is approved, the clinical trial will start immediately.
Collect clinical data so that we can better improve car-T cell therapy. "
"Today is New Year's Eve." Su Mu said with a helpless smile, "The relevant departments are already on holiday, so let's take advantage of this time to rest."
"Su Dong, now is the critical moment for clinical trials.
You can take your vacation anytime!
There is only such an opportunity to completely break through car-T cell therapy.
Moreover, conquer car-T cell therapy one day earlier.
It can save the patient's life one day earlier.
Su Dong, time is waiting! "Chen Siyi refused directly: "I think we should take advantage of the victory and pursue it."
You can help us apply for clinical trial qualifications.
For our side, first find a few suitable targets and do some preparatory work.
After your clinical trial application is approved, I will continue to follow up. "
Seeing that the scientific researchers of Chen Siyi's team were so determined, Su Mu naturally couldn't let go.
After Gao Hai organized the relevant staff of the hospital and the researchers of Dawu Biological Laboratory to make a detailed application form, he went directly to Zhang Mingyuan, the director of the Department of Health, through the back door.
For the success of car-T cell therapy.
In order to save the lives of more cancer patients earlier.
There's really no shame in going through the back door.
After Zhang Mingyuan received Su Mu's call, he was very surprised.
After all, he never expected that this kid would ask him to go through the back door.
At the same time as the accident, there is also a little bit of complacency.
But when he heard that the purpose of going through the back door was because of car-T cell therapy, he suddenly lost his composure, and asked in surprise, "Really? Car-T cell therapy research has been successful?"
"Professor Chen conducted three experiments with the control group, all of which were successful." Su Mu first explained the facts, and then continued: "However, whether it is really effective for the human body still needs to pass clinical tests.
Only when the clinical examination is qualified can it be considered a real success. "
"Well, you send the materials to the Department of Health tomorrow." Zhang Mingyuan just finished speaking, feeling a little inappropriate, and immediately corrected: "Forget it, I will bring our expert team from the Department of Health to invite a few more experts in the industry. Arrive at your Dawu Hospital at five o'clock.
Let's do an on-site audit.
After passing the review, I asked other staff of the Department of Health to work overtime to pass your application.
If it is really effective, you should put clinical trials on the agenda as soon as possible. "
"Will this...wouldn't be in line with the process?" Su Mu asked worriedly.
"Special matters." Zhang Mingyuan replied: "Our expert team review is very strict, you should prepare well and don't take chances.
If you fail the review, we will not allow you to conduct clinical trials. "
Special things can be done specially.
But the principle must never be lost!
Chapter 175 Clinical Trials
Zhang Mingyuan cooperated with Su Mu to go through the back door and handle special matters, but there was no problem.
However, this does not mean that they have to release water.
You must know that clinical trials require the participation of real people.
Once something goes wrong, at least it will cause irreversible damage to the people participating in the experiment, and at the worst it may cause the loss of life.
Therefore, when the Department of Health examines whether a new drug can be used in clinical trials, it must invite experts from various fields to demonstrate.
Clinical trials will only be allowed after the relevant pros and cons are demonstrated.
Under normal circumstances, this demonstration stage will take one to three months.
Zhang Mingyuan was able to compress three months' affairs into one day, which was already a great deal of face.
Of course, another important reason is that Zhang Mingyuan also hopes that this car-T cell therapy can be successfully studied as soon as possible.
Once the research is successful, countless patients will benefit from it.
This is a great thing for both Longguo Medicine and their Department of Health.
At this moment, Zhang Mingyuan also cared that today is a holiday, New Year's Eve.
A team of experts from the Department of Health was urgently summoned.
At the same time, five academicians from the Kyoto Concorde Hospital, 301 Hospital, and the Dragon Academy of Biology were invited.
A team of more than 20 experts was formed.
Arrived at Dawu Hospital before [-]:[-] p.m. that day.
Gao Hai is responsible for the early reception.
Professor Chen Siyi and Chen led their team to carry out related preparations.
Su Mu originally thought that a few hours for a demonstration would be enough.
The result was far beyond his expectations.
A simple demonstration work lasted for five days.
During these five days, Chen Siyi's team and the expert team basically stayed in the biological laboratory of Dawu Hospital.
Five days later, the Department of Health combined the opinions of the expert team and several academicians and agreed that car-T cell therapy can enter clinical trials.
On the fifth day of the Lunar New Year, Dawu Hospital announced the recruitment of medical volunteers.
The main requirements for medical volunteers are hematological malignancies, hematological malignancies are mainly refractory type, and relapsed type of acute lymphoblastic leukemia.
In addition, there are multiple myeloma, B-cell non-Hodgkin's lymphoma.
The age of the patient is required to be between 3-75 years old.
If you are too old, underlying diseases may affect the collection of basic data.
If you are too young, it is not conducive to the collection of various data.
Between 3-75 years old, just right.
The biological laboratory of Dawu Hospital recruits medical volunteers with cancer.
As soon as this news was sent out, the entire Dragon Kingdom completely boiled.
Department of Hematology, Kyoto Union Hospital.
"Director Zhou, are you looking for me?"
A pale man walked in through the door.
"Papa Tongtong, sit down first." Zhou Hongyuan signaled the man to sit down.
"Director, can Tongtong's hospitalization fee be postponed for another two days?" Luo Yi begged with a pale face.
Zhou Hongyuan hurriedly explained: "Papa Tongtong, don't get excited.
I'm not urging you to pay the hospital bill, I'm here to tell you some good news. "
"Good news?" Luo Yi became excited in an instant: "Has the hospital found a bone marrow that has successfully matched with Tongtong?"
"No."
"Oh..." Hearing Zhou Hongyuan's answer, Luo Yi sat down again disappointed.
"Although I haven't found a bone marrow that is compatible with Tongtong, I have found a way to save Tongtong." Zhou Hongyuan replied.
"The way to treat Tongtong? What way?"
Hearing that Tongtong was saved, Luo Yi regained energy instantly and asked eagerly.
"It's like this." Zhou Hongyuan explained: "Yesterday, Dawu Hospital announced the recruitment of medical volunteers with acute B-lymphoblastic leukemia.
As far as I know, they recruited medical volunteers this time to experiment with a new drug called car-T cell therapy.
This drug, injected into the human body, can destroy cancer cells and achieve a complete cure. "
After a long illness, Luo Yi has learned a lot of medical knowledge since his daughter became ill.
Medical volunteers, to put it mildly, are volunteers.
To put it bluntly, it is a guinea pig.
When he heard that Zhou Hongyuan was going to use his daughter as a guinea pig, Luo Yi instantly became angry: "Director Zhou, I will make up the medical expenses owed to the hospital tomorrow.
Please stop making fun of my daughter's life. "
Seeing that he was misunderstood, Zhou Hongyuan hurriedly explained: "Papa Tongtong, listen to me, Tongtong's current situation is very bad.
If no suitable bone marrow transplant is found within three months, she will probably leave us.
As her attending doctor, I really don't want this to happen.
I asked her to be a medical volunteer, it has nothing to do with money.
Even if I don't have money, as long as I have the ability, I will cure Tongtong.
She is only seven years old and has not yet enjoyed the happiness in the world. It would be a pity if she just left like this.
But the reality is that I want to save Tongtong, but I don't have a suitable bone marrow transplant.
I can only watch Tongtong fight against death day by day. "
Zhou Hongyuan paused, and continued: "The reason why I recommend Tongtong to be a medical volunteer in Dawu Hospital.
The main reason is that I participated in the demonstration of car-T cell therapy at Dawu Hospital.
I believe in car-T cell therapy at Dawu Hospital.
I can't guarantee that this treatment will definitely cure Tongtong's disease.
But, it's better than we can only watch and can't do anything now, right?
Furthermore, for this car-T cell therapy, all expenses will be borne by Dawu Hospital.
This is also good news for you.
Look at you, now you have to work three jobs a day.
Only every night can I come to accompany Tongtong.
Take a look in your mirror and see how long you haven't had a good night's sleep.
With your spirit, how can you take good care of Tongtong? "
Zhou Hongyuan knew a thing or two about Luo Yi's family situation.
Speaking of which, this Luo Yi is quite miserable.
He is a single father, and his wife ran away with others after giving birth.
This child is Tongtong.
When Tongtong was six years old, she was diagnosed with acute leukemia in a fall accident.
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