Krafft's Notes on Anomalies

"Infectious diseases have always been the focus of medical research, and there are countless pathogens. Both internal and external medicine practitioners have noticed that it is in this field that the clinical outcomes and life and death of countless patients are determined, so the pursuit of anti-infective drugs has existed since ancient times.

"In the past, Fleming used Penicillium citrinum as a material and administered it intravenously for only three days. The patient's high fever subsided and his blood test was stable. Less than 20 years later, Schatz also isolated actinomycetes from his teacher Waksman in the soil and obtained streptomycin to treat negative bacteria and tuberculosis, with remarkable results.

"I don't understand why everyone is talking about traditional palliative care, as if this anti-infective drug is destined to be the place where medicine will fail. A year ago, I went south from Wendeng Port and started research on device pharmaceuticals. Two of the three major elements of surgery were conquered. On the day when the diagnosis and treatment plan was updated, patients and colleagues were all excited. It can be said that the place is right and the people are right.

"That state of vigor and vitality, where everything is competing to flourish, is still before my eyes. Could it be that after the site and funds are in place, the situation has changed and will become an insurmountable predicament?

"No matter what, the equipment gap can be made up by other means. The advantage is mine!"

…

"Ah? Where are my bacteria?"

The former No. 2 warehouse of the monastery, now the closed laboratory of the Knights Templar.

Kraft's hand holding the glass petri dish trembled slightly, and the high cost of the dish effectively suppressed the amplitude and frequency of the trembling.

Fortunately it’s not the first time. Many days ago, the Knight Commander, who had not waited for any unusual situation to break out, had finally sorted out his daily affairs to a certain extent, and generously separated out the most closed and independent area in the monastery.

What was once a storehouse for the private property of the monastery's upper echelons has now become a laboratory, housing glass and crystal instruments that may be even more valuable.

As the wooden shelves are filled with a wide variety of instruments, the idea of ​​not wanting them to sit idle and gather dust arises, and new ideas naturally become active.

The inspiration may have come from the mold spots seen on fruit peels in humid weather, and the next day's shopping list included a large number of various meats, fish glue, bones, wheat flour and refined salt.

With a relatively rudimentary level of biological experiments and relatively sufficient culinary knowledge, a thick soup that turns into a gelatinous state after cooling was created, rich in ingredients loved by both microorganisms and multicellular organisms.

Then scrape the target mold colonies and sprinkle them into the culture dish to complete the sowing. At that time, he had already begun to worry about how to complete organic solvent extraction under current conditions.

However, subsequent developments proved that the extraction issue might have been a bit too far-fetched.

We cannot say that the training was unsuccessful, we can only say that it did not succeed in the hoped-for direction.

It is comforting to say that at least the culture medium is well made and the results are of high artistic quality.

The rich colors of the thriving growth inside are a constant reminder of the high similarities between the local and Westminster microecological environments.

If an artist were here, he would surely be inspired to spend a lot of precious pigments to create a rare painting that would wake Kupp up in the middle of the night.

Fortunately, there are no artists or Kupp here.

The latter had already led the team down the mountain. I don't know what the situation is like, and it is estimated that there will not be much progress in the short term.

Kraft was willing to trust him; this assistant already had enough experience for preliminary investigations and was cautious and conscious.

It might seem a bit cowardly if viewed from a negative perspective, but for the work he might undertake in the future, knowing when to retreat three miles is more important than meaningless bravery.

There will certainly be times when you make mistakes in judgment, but there is no need to worry too much.

After all, she was paired with Yvonne.

Even Kraft felt relieved and refreshed at the thought of not having to do everything himself. It was immediately decided to divide today's paperwork between Brother Raymond and leave him some free time.

Apart from the unsuccessful experiments, he is very satisfied with the new laboratory.

It has ample space and complete equipment, which is probably only comparable to the Medical School of the University of London when Professor Morrison was still alive.

No, even the University of Dunling would not have such a large number of new glass instruments.

Rows of odd-shaped white glass pots and kettles are stacked in boxes lined with pure cotton. Perhaps they are also curious about why the owner of the experiment spends all day observing the broth instead of focusing on complex physical reactions.

His failure was apparently due to the difficulty curve being too steep.

The correct choice should be to pour out the culture dish that has all the red, orange, blue and purple colors except green as soon as possible, wash your hands, lock the door and go next door.

The monastery's charity clinic is about to open, so we have to prepare some of our best supplies as soon as possible, otherwise the monks who are not as capable as David V will have nothing to offer except prayers and boiling water with grass roots.

But what he has to do is essentially not much different from boiling grass roots in water.

Chop up two bundles of dried willow bark on the table and put them into a round-bottom bottle. Pour in high-concentration alcohol and immerse the whole bottle in warm water to heat it.

As a natural medicine, willow bark should theoretically be rich in salicin, which can be extracted by alcohol.

The content is uncertain, no one has taught it or seen it. Kraft was only familiar with industrial products and the way starch looked after it was pressed into tablets and bottled.

Wait until it's almost done - of course, he didn't know when it was almost done, he just stared at the liquid in the bottle as the color gradually darkened from light yellow to amber, and then took it out to cool.

Theoretically, salicin should have been transferred to the alcohol along with the pigment at this time.

The next step is to filter out the bark and continue heating to evaporate some of the alcohol and concentrate it until a more concentrated solution is formed - don't boil it.

Then the color of the liquid continued to darken and turn to brown, and the suspicious remnants of incomplete filtration, like tea dregs, churned up and down, like the uneasy mood caused by the rough operation.

Out of concern, Kraft filtered it again with fine cotton cloth and added dilute sulfuric acid. It was a little too much, but it didn't matter, because in theory an acidic environment was needed anyway.

When the acidity is appropriate, the solution will contain the hydrolysis product of salicin - salicyl alcohol.

If I'm correct, according to a casual mention in the corner of the extracurricular interest extension section of the organic chapter of a certain medical chemistry book, now just drop concentrated sulfuric acid in it, the solubility of the oxidation product in the acidic environment is very low.

It's that simple, two bundles of willow bark, alcohol, sulfuric acid, plus glassware worth a house in the old town of Dunling. The snow-like precipitation that you witness next is the precursor of the legendary non-steroidal anti-inflammatory analgesic drug aspirin... salicylic acid.

Compared with its acetylated brother, it has low solubility, poor absorption, weird taste, strong gastrointestinal side effects, anti-thrombotic effect is almost zero, and it is so irritating that it can be used to exfoliate the skin, but its strength lies in that it can be achieved under existing theoretical conditions.

This was the limit of what he could do, and his operating level was still far behind Father Adrian, the master distiller of Port Solace who controlled fire with his bare hands.

"No, why isn't it settling?!"