Rebirth of the God-level Xueba

"Director Yang, what's the situation here?" Pang Jiancheng asked Yang Rui with a smile, thinking: The acting skills are quite good, and Peking University is really a hidden dragon and crouching tiger.

No one thought that new research results would come out, and Pang Jiancheng couldn't think of it naturally. Only when Yang Rui arranged this place, he was a fan of him.

On the contrary, a few foreigners, listening to the "three-dimensional structure" of the translator, began to whisper.

Yang Rui hesitated for a moment, then coughed twice, and said, "There seems to be good news coming out of our laboratory, everyone, wait a moment."

After speaking, Yang Rui followed the student back to the laboratory and asked for the photos he took.

Gu Qiang and a group of people gathered around the electron microscope with different looks.

"I want to be idle or idle, so I took a few pictures. However, I used the remaining materials from the second stage of the repeated experiment. I don't know if it will interfere with the results of the experiment." Gu Qiang was a little proud. Somewhat worried to explain to Yang Rui.

The boss of the laboratory has all the power in the laboratory, and the people underneath have made the results, and they must be approved by the boss.

Otherwise, if the person in charge of the worst laboratory refuses to admit the experiment results of his subordinates, or even reprimands them for being false, then his subordinates can only swallow tears in their stomachs-going to other laboratories to repeat the experiment is just talking. Simple things that are difficult to do, otherwise, Yang Rui would not mobilize everyone on that day, and use a lot of experiments and resources to do the second stage of repeated experiments. That is still in the case of a laboratory, and it will be even more difficult to change the laboratory. .

Not only that, researchers who leave the lab of big-time scholars will also encounter many other problems. Even if they prove their previous views, they will not affect big-timers-you have achieved results this time, both It cannot prove that you did not cheat this time, nor can it prove that you did not cheat last time.

Galileo’s experiment in which two small **** dropped at the same time was suspected of being a fake. The correct theory does not mean that the experiment is correct.

On the contrary, more scholars who have ruined their reputation and left the scientific research community.

Therefore, no matter what results Gu Qiang has made, his first and best choice is always to be recognized by Yang Rui, and then see how much credit Yang Rui can give him.

After the streptomycin incident, the value of the academic community to specific executors has become quite clear.

"Disperse a little bit and do your own thing." Xu Zhengping expelled everyone around him before Yang Rui started to watch the film.

Before the paper is officially published, the electron microscope photos are first-hand evidence and first-hand information, and they must not be shown to others.

Biologists have always criticized Watson and Crick’s Nobel Prize for sharing the double helix structure of DNA. One of the reasons is that they suspected that they had peeked at Rosalind Franklin’s X-ray crystal diffraction pattern-of course, they would definitely see it. Yes, the key to the question is whether to take a peek or not, because Ms. Franklin died young, and the arguments in it can no longer be refuted.

However, the crux of the problem is actually a photo.

However, what kind of photo is the X-ray crystal diffraction pattern of dna taken by Rosa Linde? White flowers on a black background, two intersecting black reflection bars, thrown on the street, no one wants to take a closer look.

Watson later wrote the book, saying that he was dumbfounded after a glance, his heart pounding, because only the spiral structure would show up as two crossed black reflection bars on the photo.

No matter what the photos Gu Qiang made, it should not be made public in the laboratory before the paper is published.

Just a reminder from Xu Zhengping, all the researchers woke up and returned to their positions one by one, leaving only Gu Qiang to look at Yang Rui nervously.

Yang Rui nodded to Gu Qiang, then took out the photos and read them carefully.

Compared with others, Yang Rui has always had an advantage in reading images.

He does not read the specific image of the photo, but only sees whether the image conforms to the theory of three-dimensional structure, which is what all people who look at the image need to do. The chapters on why the eight forms of fractures are studied in the school are used to check whether there are corresponding elements in the image. If there are, it proves that there is a fracture, if not, it proves that there is no.

However, scholars in the 1980s did not know much about the three-dimensional structure of g protein coupled receptors, which gave Yang Rui a comparative advantage.

He only looked at it for a while, then put the image back in the bag, and then looked at Gu Qiang with a scrutiny gaze.

"Director Yang..." Gu Qiang yelled out of vacillation.

"Did you record the experiment?"

"Done." Gu Qiang quickly took it out. This is a good habit, and it is also a place where the ion channel laboratory is stronger than other laboratories. .

Experiment records are useless in most cases, but when you find something, especially when it is a world-class discovery, your only regret is that the experimental record is not detailed enough!

"It would be fine if I..." is often said by people who have not received system training.

The purpose of system training is to prepare researchers to seize every hard-won opportunity. After all, the number of times a person can step on **** in a lifetime is limited, except for Gu Qiang.

Yang Rui glanced at Gu Qiang again, and after reading the experimental record, said: "There is no problem for the time being, but I still want to see repeated experiments."

"Of course." After Gu Qiang finished speaking, he whispered: "In this case, is the three-dimensional structure made?"

Yang Rui hesitated for a moment, and said, "Basically."

"Yeah!" Gu Qiang yelled lowly.

"We need to perfect the remaining parts and draw the three-dimensional structure, but that's basically it. The rest is rough work." Yang Rui said with some emotion.

Regarding the third phase of the experiment, that is, the three-dimensional structure of the g protein coupled receptor, the most important and main requirement is to find the activation mode of the tiny extracellular ligands and the g protein coupled receptor.

To put it simply, the g protein-coupled receptor is a kind of protein, although it is invisible to the naked eye, but at the molecular level, it is a very large existence. It is like a molecular building, with people and cars coming in and out constantly.

These people or cars going in and out are extracellular ligands.

For example, how does the human sense of smell come about?

The outside air contains various molecules. They enter the human nose. Some of these molecules that can be distinguished by humans will come into contact with a certain g protein-coupled receptor of the human body. This molecule enters Pedestrians in the g-protein coupled receptor building.

Pedestrians enter the building, and the building sends a signal to the brain. The brain searches for information and tells humans what you just smelled.

To delineate the three-dimensional structure of g-protein coupled receptors is to describe the appearance of this building. The most difficult part is not the outline-the outline of the huge g-protein coupled receptor is still easy to make, the most difficult and the most difficult. The main and most important part is to see how it accepts pedestrians and vehicles.

Specifically, it is to look at the position and shape of various openings on the g protein coupled receptor molecule.

In other words, what humans want to know is where the elevators of this g-protein coupled receptor building are, where are the garage doors, where are the front and back doors, and whether there are overpasses and rooftops.

Scanning g-protein coupled receptors with instruments is like scanning a building with a laser. They don't really see everything about the building, but rely on various feedbacks to get answers.

It is like shining a laser beam on the door of a building. If the door is closed, the laser will give a reflection and get the wrong answer that there is no way here.

The scanning of g protein-coupled receptors is more complicated, because the protein is mobile, and it will show the necessary three-dimensional structure only when it has a relationship with extracellular ligands ~www.wuxiaspot.com~, otherwise, It is a closed protein.

Speaking of which, g protein-coupled receptors often exchange with the outside world, but to grasp such a momentary picture is a very good test of luck.

Historically, it took Kobe Carr about 4 years to explode in character, and he captured the scene that he needed—the moment when a certain extracellular ligand touched the g protein-coupled receptor.

Gu Qiang spent about four months doing related research.

Shit luck has defeated hard work. It has happened countless times in history, and it will not be the last.

It's just that for Yang Rui, this time is too coincidental.

"You continue to repeat the experiment and write down all the experimental records you can think of." It is impossible for Yang Rui to give up this achievement. The next time he takes a picture of what he wants, the ghost knows which century it is.

However, Yang Rui cannot let these achievements be exposed to the Swedes unpreparedly.

The temptation of the Nobel Prize cannot be resisted by any scholar.

"Who can take over and repeat the experiment?" Yang Rui asked in a loud voice.

Several researchers looked at each other, and finally Su Xiankai stood up.

Yang Rui nodded and said, "Now separate the second phase of the experiment from the third phase. The electron microscope is not allowed to move, Tian Bing, you will assist Gu Qiang in making the record."

It is a normal procedure to complete the record before repeating the laboratory.

After a little fuss in the laboratory, Yang Rui glanced at the electron microscope again, and even though hesitated, he went out.

"Everyone, we have just completed a new round of repeated experiments, which proves that we have obtained the complex of the n-terminal ligand domain of the g protein coupled receptor and the ligand, and the crystal structure diagram has been completed." Yang Rui In a declarative tone, he faced a group of Swedes whose tongues were hot pot.

...