Rebirth of the God-level Xueba

The more than 30 compounds used in animal experiments were all synthesized step by step by Yang Rui.

Naturally, Yang Rui knows exactly the outcome of these compounds.

In the final analysis, Yang Rui only needs one or two compounds in the end, no more than four at most, and the remaining compounds are to be eliminated.

If you want to speed up, the best way is to let the eliminated compounds be eliminated as soon as possible.

The reason why the screening of active substances is getting slower and slower is naturally because the remaining compounds are getting safer. Those obviously unsafe compounds, such as compounds with acute toxicity, have been brushed out in the first few tests. .

But in the next test, those unsafe compounds will eventually be eliminated, it's just a matter of time.

The problem is that Yang Rui doesn't want to wait that long.

Some tests will not be carried out until a long time later, and some are not even needed in the 1980s, but only in the 1990s.

However, as a new drug developer, considering the situation ten years later, it is simply too normal. Ten years later, new drugs may not be on the market yet. Even drugs that are on the market may be withdrawn.

For example, a large number of drugs withdrawn in the 1990s are metabolized by mixed-function oxidases. This is not a problem in itself. However, patients often do not take one medicine, but combine multiple medicines. The result is these. Drugs metabolized by mixed-function oxidases are very likely to cross-react. Such consequences will either not be tested in animal experiments or will be the final test.

Because drug cross-reactions are not the focus of animal experiments.

But from the perspective of whether a drug is successful or not, drug cross-reaction cannot escape.

Similarly, there are genetic toxicity issues, metabolite issues, pharmacokinetic characteristics, and even whether the raw materials are easily available, and whether the synthesis cost is reasonable and low.

These issues are not considered by ordinary people, but they must be considered by pharmaceutical companies. For example, for cold medicines 10 years from now, they will definitely not consider products that are used as raw materials. Some raw materials that must be closely monitored have this problem.

If you think about it, you can understand that if you buy a box of cold medicines, you need to check the ID card and limit the quantity. The sales can be imagined. Putting it in Europe and the United States is equivalent to turning non-prescription drugs into prescription drugs. , Pharmaceutical companies cannot be careful.

In short, all the work of pharmaceutical companies is done cautiously.

Whether a drug can become a clinical candidate compound after the end of animal experiments, for pharmaceutical companies, means whether it will cost US$20 million to US$200 million and wait four to five years for clinical research.

Such an amount and time are enough for the two countries to wage a local low-intensity war, so how can pharmaceutical companies be cautious?

What Yang Rui needs to do is to eliminate the compounds that are destined to be eliminated as soon as possible, so that he can concentrate his time and energy on a few compounds, and then make detailed tests and analyses.

In the end, if these few compounds can meet the requirements of clinical candidate compounds, even if Yang Rui cannot personally promote them to market, pharmaceutical companies will actively do it.

The only trouble is that such elimination work requires Yang Rui to spend more time participating, not the other way around.

This naturally takes some precious time.

However, Yang Rui also feels that he needs such an experience. Deferiprone is what he wants to do, not the medicine that Huarui needs. But one day, Huarui’s laboratory will need to make its own medicine if it wants to grow and develop. By that time, Yang Rui hopes that he will be a manager with pharmaceutical experience, rather than a novice layman with great ambitions.

Yang Rui occupied two compartments in the main laboratory and began the design of animal experiments.

Wei Zhenxue and Wang Xiaoyun are still in charge of animal experiments. Yang Rui only makes requests and does not directly participate in the experiment results.

After all, animal experimentation is not a good time, even if the 3r principle is adopted, some experiments are still uncomfortable.

As a graduate student in the Department of Biology, Yang Rui has over a hundred rats, but this does not mean that he likes this work.

On the other hand, feeding the compound, observing and calculating the results, and ultimately killing the animal, does not require Yang Rui to do it himself.

Yang Rui is busy designing experiments.

In order to pass the fda or possibly the drug administration of European countries, Yang Rui must first make a detailed experimental record, including the preamble and follow-up questions, that is, what he thought, how he did it, and the result.

To be more specific, it is why you think so, why you do it, what you do, and the meaning of the results.

This kind of complicated process can protect the public to the greatest extent and also restrict the progress of scientific research to the greatest extent.

However, although Yang Rui was busy enough, his progress caught Wei Zhenxue and Wang Xiaoyun off guard.

In just two days, the two of them couldn't handle it. When Yang Rui checked, they found that they hadn't even completed one-third of their tasks.

"The reaction time of the white mouse is not determined by us." Wang Xiaoyun explained helplessly, still busy writing the experiment report, they had to write more things than Yang Rui.

Wei Zhenxue was so tired that he couldn't turn his head. He just said, "I haven't slept all day and night, boss, let's add an assistant."

Yang Rui, who works for 110 hours, was shocked to see Wei Zhenxue like this, and asked Wang Xiaoyun: "You really haven't slept all day and night?"

"I slept yesterday, and Lao Tu helped me a little bit." Wang Xiaoyun was a little embarrassed.

"Where is Grace?"

Wang Xiaoyun hesitated and said, "She said she would not accept your order."

"why?"

"Chaotic life, probably means this." Wang Xiaoyun said: "Grace continues to follow the regular steps little by little."

Yang Rui pondered and asked, "What about you, do you think my experimental design is correct?"

"We have already screened out a compound. From the results, the experimental design can be used." Wang Xiaoyun didn't need to flatter Yang Rui, saying it was very true.

Yang Rui nodded slightly ~www.wuxiaspot.com~ and said, "Then continue with the current state...Is it no good if you don't add people?"

"You must add people, at least people stop the instrument and keep on, so as to speed up the screening."

This sentence moved Yang Rui. The equipment in the laboratory is limited, but it is still feasible to use it without time.

"I will help you find two more people." Yang Rui is unwilling to increase the laboratory staff too fast. The cost is on the one hand, and the limited resources are on the other. The busyness of the laboratories in the Huarui laboratory is second to none. .

After some blending, the number of compounds quickly decreased.

Only the drug cross-reactions that are not usually done, three compounds were screened out in one go. If this method is not used, these three compounds may cost the experimenter hundreds of hours, and after tens of thousands of yuan of funds, Was eliminated.

Within a few days, the number of candidate compounds dropped to an astonishing eight, and Grace couldn't help but come to learn from her experience.

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