Rebirth of the God-level Xueba

After Wu Hongbo was touched, Yang Rui's plan couldn't have been smoother.

If you look down in the domestic biology community, the number of people is too large. You don’t know how many people are for biology teachers in ordinary primary and secondary schools. However, when you enter the scientific research community, especially when you look up, the number of people at the top of the pyramid is extremely small. .

Wu Hongbo started to show up, and with the wonderful reward of traveling in the United States, Huarui Lab quickly issued six invitation letters.

At the same time, Yang Rui continued to communicate with several pharmaceutical companies and actively communicated with Benjamin Law Firm.

The content of his communication was mainly PCR lawsuits, and price negotiations involving deferiprone were unavoidable.

Benjamin filed a lawsuit for Huarui and DuPont as a partner named by a well-known law firm, not only for the attorney fee of $2,000 per hour, but also for contracting more business.

The landmark gambling agreement, such a high-value contract, has always been a favorite of lawyers.

The milestone contract is extremely complicated, and coupled with the existence of the gambling agreement, a little carelessness will lead to being cheated. Pharmaceutical companies, like financial companies, are inherently evil and never credible. Lawyers are naturally indispensable.

Within a few days, almost all pharmaceutical companies accepted the milestone gambling agreement model, and then began lengthy detailed discussions. Some companies had to consider whether to establish a joint venture subsidiary in accordance with Yang Rui’s requirements. This work.

In fact, the cost of developing new drugs is too high for some medium-sized pharmaceutical companies to bear independently.

The average development cost of the first clinical phase is US$1 million, and the milestone requirements are US$1 to US$55 million. This means that pharmaceutical companies may have to prepare a budget of more than US$56 million for this purpose-although they cannot give Yang Rui as much as they want. How much, but the budget still has to be prepared to be eligible for competition.

The average development cost of the second clinical phase is US$20 million, and the milestone requirements are US$20 million to US$60 million, which means that pharmaceutical companies may have to prepare a budget of more than US$80 million for this.

The average development cost of Phase III is US$100 million, and the milestone requested by Yang Rui is US$30 million to US$90 million, which means that pharmaceutical companies may have to prepare US$190 million for this.

As a milestone project, the maximum budget of the entire project may reach 330 million US dollars, which is not cheap anyway. That is, the sky is asking the price to pay back the money. At most, one-third of the budget is cut, and the final cost is still US$200 million.

This is actually the average development cost of a common drug.

Of course, the $200 million cost of the pharmaceutical company is a phased expenditure, which also means that Yang Rui's income will also be phased.

The easiest place for him to get money is the milestone of the first phase of the clinical trial. As long as the safety clinical trial passes, he will receive at least one to twenty million dollars, and as many as four to fifty million dollars. As long as the contract is signed, the money will almost certainly be available within half a year.

As for the second and third clinical phases, it will take a long time. If the pharmaceutical company decides to sell the iron ketone directly after the first phase, it may take longer. And its income is not necessarily more than that of the second period. In fact, as far as Yang Rui knows, the money received in the second period may be less than that of the first period.

Because from the second phase, a lot of risks and costs are actually concentrated on pharmaceutical companies. However, Yang Rui's contribution to the end of the animal experiment was mainly fulfilled in the first phase of the clinical trial.

According to the usual process of pharmaceutical companies, it usually takes three to four years to complete the second phase of the clinical trial. It is not surprising that it takes five or six years to complete the clinical phase.

The third clinical phase is far away. The development cost of US$100 million is mainly caused by the scale of 20,000 people. The average cost of US$5,000 per person cannot be said to be sufficient. The 20,000 people were not found randomly, but they all needed the doctor’s approval or even introduction, and signed a complicated contract before they could proceed in batches. The degree of difficulty is even more difficult than selling a listed drug. Only the largest marketing pharmaceutical companies can easily carry out this kind of work. Smaller pharmaceutical companies have to mobilize all of them to make another entrepreneurial effort. Row.

Yang Rui's eyes were mainly focused on the first phase of the clinical trial. All the seven compounds in the first phase of the clinical trial have passed, and he can get the most part. If he is lucky, there may be 40-50 million. As for the second and third phases, he can get two 30 million dollars at most.

Of course, the final listing will also give him a generous bonus milestone. Maybe it can talk about the scale of tens of millions of dollars, but the time will be longer, maybe it may not be ten years.

"Time is really the least durable commodity." Yang Rui looked at the schedule set by Benjamin Law Firm and couldn't help feeling.

"For you, in the days to come, you can just wait to count the money. Hey, if I knew that doing scientific research was so profitable, I would not go to law school." Hong Kong lawyer Yue Ting gradually replaced Huarui. The little lawyer with a sense of existence has officially become Huarui's corporate lawyer. He also knows some of the relationship between Huarui and Yang Rui. At this time, looking at the documents sent by Benjamin Law Firm, he was even more deeply moved.

The charge of $600 an hour is certainly expensive, but it is still out of reach to earn $10 million.

Thinking that Yang Rui easily got the first tens of millions of dollars in his life, he was only in his early 20s, and he was still in the still closed mainland. Yue Ting was also full of emotion.

Yang Rui just smiled, and said, "I care more about money than counting money. You have to make a contract with Zelecom as soon as possible and sell the catalyst of Coenzyme Q10 first."

"Ok."

"Has the ticket to the United States been booked?"

"The PCR lawsuit is the first priority, and this must be dealt with."

"No problem, Benjamin also attaches great importance to PCR. This lawsuit is well-known in the American judicial and scientific circles, and the business community and Wall Street are also very concerned."

"Of course they are concerned. For small companies to large consortiums, if I were not fully prepared, I wouldn't know how to die." Yang Rui is also following the lawsuits in the United States at any time, but the more concerned he is, the more frightened he is.

Naturally, the huge DuPont consortium didn't come here to get a deal.

They actually have a chance to win. Yang Rui thinks this kind of thing is incredible when he thinks about it. PCR is obviously made by me, and it is possible for DuPont to win.

However, this is the law of the United States.

DuPont used two Nobel Prize winners and a large amount of scientific research evidence to forcibly break out a way to prove that it has related research since the 1970s.

Don't say, they really do.

It was also Yang Rui who published an article before, did pre-research on heat-resistant polymerases, and also had a large number of video tapes, and also invited Nobel Prize winners, coupled with the joining of a large patent law firm, which made Yang Rui stable. Up the situation.

Despite this, the debates and several court sessions between the two sides lasted for more than half a year, and they actually aroused considerable discussions in the industry.

As a result, Yang Rui had to add money to Benjamin Law Firm, which slowly increased the budget of the lawsuit to nearly $4 million.

For the Chinese, this is indeed an astronomical figure. Yang Rui has thought about it more than once in private. If he hadn’t foreseen the future of PCR, and had accumulated enough funds and made sufficient preparations, this lawsuit was really true. There is no need to fight.

US$4 million is not the final cost, and victory is not an inevitable result. Think about how depressed it would be if you spend more money and get lost or reconciled in the end.

With so much money, if you bother to convert it into RMB, you can get more than 30 million yuan to buy a house in Beijing @京, you can buy hundreds of courtyards, and it will easily sell for tens of billions of yuan in 30 years.

It may not be worth the $3 billion value of PCR, but it is much simpler.

After all, to realize the PCR value of 3 billion US dollars, it is still necessary to pay and operate. The house is there, but it is much simpler.

Why Chinese companies are unwilling to go to the United States to file a lawsuit? Why Chinese state-owned companies would rather suffer losses than protest? You can understand by calculating the economic accounts. If the leader of a pharmaceutical company spends US$4 million to file a lawsuit and then loses carelessly, it is really a lack of career. Even if he wins, he will probably stop on the official road.

However, the rights and interests of PCR are wholly owned by Yang Rui, and Yang Rui can only bite his teeth and sign the checkbook and hand it to Yue Ting.

Yue Ting carefully checked the signature and spelling, and said with a smile: "It's okay, I will save it to the Cayman company."

The offshore company in the Cayman Islands is the superior company of Huarui. On top of the offshore company in the Cayman Islands, there are also multi-level offshore companies to help Yang Rui control Huarui while hiding himself.

"Thank you." Yang Rui put down his pen and said with a silent smile: "More than one million US dollars as a lawyer's fee, I really didn't think about it before."

"Attorney Benjamin’s fees are high, but it’s really powerful. Hong Kong companies are generally not able to hire such a barrister in lawsuits in the United States." Yue Ting smiled and said: "Recently, we’d better keep in touch. I report to you the quotations of various pharmaceutical companies at any time, and you may also make a decision to notify me."

"Okay." Yang Rui nodded, "I have been in the Huarui Lab without Peking University in the past few days."

"The scope of Peking University is too wide. It's best to have a telephone."

"There is a telephone in the ion channel laboratory, but if I go to class or stay somewhere in the dormitory, there is nothing I can do."

Yue Ting thought carefully. From his point of view, it is indeed very important to find Yang Rui in time. He can substitute for Yang Rui to negotiate, but important issues cannot be decided for Yang Rui. If every time he finds someone, he wastes a few hours. The progress of the negotiations can be imagined.

In case someone like Arnold appears again, give an hour to determine the time or something~www.wuxiaspot.com~ Yue Ting doesn't know what kind of loss it will cause.

After thinking about it, Yue Ting patted his forehead and said, "Can we get a pager? The pager is a bit like a telephone, but it can only call people in one direction. Once you see the number, you know that someone is looking for it, and the machine is not big. , Smaller than a slap..."

"BP machine?" Yang Rui was even more surprised than Yue Ting: "Is it there now?"

"It's called this name, you know?" Yue Ting shook his head for a moment, and answered Yang Rui's question directly: "I heard people say that Shanghai @海 has just set up a public paging network this year, and Bei@京的正办, I don’t know if it’s done well, but some units have their own paging stations, such as hospitals and customs. I wonder if they can join the self-organized wireless paging network through people?"

Yang Rui looked at Yue Ting with weird eyes, and said, "You know more about technology than I do."

"Where and where, I am more concerned about things that can save time." Yue Ting smirked thoroughly.

Yang Rui complained inwardly: "I mean the technique of pretending to be force."

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