Rebirth of the God-level Xueba

"Your idea... will face a very important problem. If the U.S. Congress, or any country’s funding agency, fails to see our output, the Genome Project may be suspended..." Dalbecco obviously also I thought about the question of whether to do the technology first or do the sequencing first, but did not decide.

Yang Rui said: "The Human Genome Project will be very different from other projects."

"of course."

"If the current technology is adopted, sequencing will be very, very long. Indeed, if we directly sequence and use existing technology and tools, we may be able to get some results in the first year, 50,000 base pairs?" Yang Rui disdain He smiled and said: "Our goal is 3 billion base pairs, and with the current level of technology, if we don't make a lot of investment, we will not be able to complete the entire project even with a budget of 15 years."

"But from the perspective of Congress and the public, we got at least 50,000 base pairs, which is a visible benefit, right? In the process, we can still continue to develop technology, and the sequencing itself , Can also help us develop technology, can't it?"

Yang Rui said without hesitation: "It's impossible. Sequencing itself is a physical activity. We need to pay attention to the method of sequencing and the results of sequencing. As for sequencing itself, it is meaningless."

Dalbecco was a little surprised by Yang Rui’s arbitrariness, but he is also a person who has been in the front line for many years. After thinking about it, he has to admit: "You have a certain truth. But I think even the Congress will demand us Sequencing while developing technology."

"If I choose, I don't recommend this." Yang Rui shook his head and said: "Even if we do our best to sequence, the results of the first and second years will be ugly. In that case, why should we take it? The results are coming. Let me say that in the first year, the second year, or even the third year, we should not perform even one base pair sequencing except for testing."

Not only Dalbecco, Professor Tsai and Tobias were also stupid.

This is the first time that Yang Rui has put forward his own opinions. He did not agree with Dalbecco's opinions, but contradicted Dalbecco's opinions.

Regarding the relationship between the two people, as well as the relationship and position in the future, Yang Rui's performance at this time is of decisive significance.

Of course, the opinions he put forward are also very decisive.

Dalbecco couldn't help thinking deeply, and after a while, he asked: "Why? By doing this, our pressure will greatly increase."

"As long as the project is established, such a huge project, even those who are eager for quick success and instant benefits, will not require us to give results in one or two years. Therefore, we will completely abandon base pair sequencing in the early stage and focus on technology. I think that although the pressure will increase, it will not increase too much. In the third year, the pressure may increase a lot. At that time, it is possible to do a certain amount of base pair sequencing." Yang Rui explained softly.

"Is it necessary?",

"It's very necessary." Yang Rui said: "We don't sequence any base pair. We can explain to investors or the public that we are adopting a technology-first strategy. Our current preparations are for faster completion in the later stage. Base pair sequencing is more cost-effective. Once we have sequenced, for example, in the first year, we have completed the sequencing of 50,000 base pairs. What is the result? Will investors and the public be happy?"

Dalbek hesitated: "No?"

"Of course not, because anyone knows this simple calculation. It took us a year to complete the sequencing of 50,000 base pairs. It took 10 years to complete the sequencing of 500,000 base pairs, and it was 5 million in 100 years. , Only 50 million sequenced in 1000, so all media will come to a conclusion that the human genome project is over." Yang Rui took out the big trick he had prepared for a long time.

Dalbecco was stunned, and in a flash, he said: "We sequenced 50,000 base pairs in the first year. This does not mean that our progress next year will continue to be the same. Our progress in the second year may be 1 million base pairs. It may be possible to complete the sequencing of 10 million base pairs in three years."

"In that case, why don't we re-sequence the next year? Ordinary people cannot predict the speed of science and technology development. They will use their salary increase to judge technological innovation, such as 10% progress, or more, doubled However, no one would believe a 20-fold increase, and if I want to judge, a 50-fold increase can be achieved."

"You mean, with a technology-first strategy, you can have 50 times the previous rate in one year?"

"Yes, and only with this method can we complete the genome project as quickly as possible and gain a competitive advantage." Yang Rui was actually a little emotional. The Human Genome Project has been underway for more than ten years and spent more than 2 billion US dollars to complete the sequencing of 2.3 billion base pairs of the human body for the first time.

However, by 2015, the cost of sequencing the human body’s 2.3 billion base pairs once has been reduced to $99, and the time consumed is measured in hours.

This speed of technological innovation, even for Dalbecco, may not be predictable.

It should be said that Yang Rui tried to influence Dalbecco's decision based on past experience.

Dalbecco has indeed been affected.

If someone else said this, even Professor Tsai, or even someone like Professor Richard of the University of California, Berkeley, would say this, Dalbecco would not be affected.

But Yang Rui is different. Yang Rui is the inventor of pcr, and Yang Rui is also the pioneer of genomics.

Dalbec has been following Yang Rui's research from beginning to end. As far as the current genetic research scholars are concerned, they have not ignored Yang Rui's work. The so-called name of the shadow man of the tree, Yang Rui's performance in the past two years, determines the value of his thinking.

If Dalbecco chooses, who is most qualified to estimate the development speed of genetic technology, Yang Rui may not be the first candidate, but if Dalbecco is to make a choice between himself and Yang Rui, he believes in Yang Rui more.

The so-called technical expertise, Dalbecco's research in the field of genes, especially in the field of genetic technology, is far less in-depth than Yang Rui, and Dalbecco is no longer young.

A scholar’s ​​research life can last a long time, but he has to rely on himself, especially his own intelligence and physical strength to complete the research work. The age is usually under 40, at least under 50.

This is the golden age of scholars. Scholars who are over 50 years old can be a competent academic leader, a competent laboratory manager, and a competent project manager, but they are not suitable for rejection. The academic achievements of scholars whose energy, physical strength and intelligence are at their peak.

"Do you think that by adopting technology-first means, we can catch up with the results of parallel technology in a few years?" Dalbecco has a tendency in his heart.

"Three years. If the sequencing starts in the third year, it will not be a problem to complete the sequencing of millions of base pairs by the end of the third year. If the sequencing is not performed in the third year, the first half of the fourth year will have a chance to complete thousands 10,000-level sequencing.” Yang Rui is very confident about this. The Human Genome Project is a very large project, which means that it is a project with very substantial personnel and funds. As long as you choose the right direction, the results will be very fast.

"Your prediction ~www.wuxiaspot.com~ is based on it, right?"

"of course."

Dalbeck thought for a long time and admitted: "If you can really achieve a sequencing speed of tens of millions of levels, your plan may be really better."

He raised his head and said, "Would you like to write an article on this?"

"No problem." Yang Rui has been training for so long, and writing an essay is done by hand. As for the basis, it is not difficult to prove that this is the case.

"Our Beijing Conference is fully cooperating." Professor Cai turned it into a cooperative project in a timely manner.

Yang Rui said indifferently: "Then use the ion channel laboratory to do it."

Professor Cai nodded and said, "I agree."

Of course, Dalbecco didn't care any more. After confirming the matter, he asked more actively.

In his heart, there is also a thought that is getting closer and closer.