Rebirth of the God-level Xueba

"Let me first talk about the current development of medicine and biology at home and abroad. A few words to explain clearly." Yang Rui thought for a moment, and said: "In short, since the 1970s, the world's new drugs have been developed. During the golden age, a series of original drugs and imitated innovative drugs were launched successively. The first β-adrenergic blocker propranolol, the histamine H2 receptor blocker cimetidine and ranitidine were synthesized. These are the first cases. Many patients have been saved and the profits are high. The result is the development of new drug research theories for nearly 20 years, and the development of various technical platforms and methods is also very fast. For now, China has not kept up with the times at all."

Yang Rui glanced at the three of them and saw that they were indeed listening, and continued: "As far as we are concerned, our backwardness in new drug research cannot be changed in a short time. The reason is also very simple. Our country has no money. At present, the investment in new drug research and development is about 400 million US dollars per drug, but this number will soar rapidly. As far as I predict, by the end of the 1980s, the capital cost of a new drug will rise to 1 billion to 15 billion US dollars. Billion U.S. dollars, and the R&D cycle has increased to 10 to 12 years..."

Yang Rui made a prediction indifferently, but he didn't know that this kind of prediction seldom appeared when giving lectures to the big guys-it's okay if you guessed it right, isn't it finished if you guessed it wrong?

Yang Rui was not afraid of this. He talked about many problems in drug research and development without any restraint, and then diverged about the domestic biopharmaceutical industry.

He was so familiar with these contents, he could say it accurately and in detail without thinking too much.

The three listeners also listened very seriously. The pharmaceutical industry is currently one of the few high-tech industries in China that can earn foreign exchange. Although relative to the international level, high-tech is very reluctant, but after all, it is also a very important industry. It is naturally necessary to spend two hours to understand it.

Gong Tang even took out his notebook and made a brief record, and when Yang Rui paused, he asked: "Yang Rui, I heard that you have made a new medicine that has been sold to foreigners. It is of high value?"

Yang Rui did not shy away from saying: "Yes, what I signed is a milestone contract. The total value of the contract exceeds tens of millions of dollars."

The three of them looked at each other, and no one asked the question of where the money went.

Tang Gong asked with great interest: "If such a drug is developed in China, is it possible?"

Yang Rui thought for a while and said, "Although I don't want to say it, I think it's impossible."

"Yep?"

"The research and development of new drugs is a probabilistic issue. Looking at it now, the cost budget for developing a new compound is 50 million U.S. dollars. Of course, 5 million U.S. dollars may be achieved, but 5 million U.S. dollars may not get anything. So, in order not to lose money, a budget of 50 million US dollars needs to be prepared." Yang Rui paused, then said: "The domestic budget cost may have to be higher. After all, there is no equipment. You have to buy all of them. I'm talking about making new compounds, just like what I did before. If a complete drug is developed, it will take longer, less efficient, and even more unrealistic."

"So, domestic pharmaceutical companies can't make original drugs?" Tang Gong looked a little regretful. He was probably the kind of people who could not see the loss of profits.

After thinking about it, Yang Rui said: "I agree to make generic drugs first and then original drugs, but the goal of making generic drugs should be to make original drugs, not just copy them all the way."

Yang Rui paused and said, "Intellectual property rights and patent protection are the basis for new drug research and development. Otherwise, no company would spend $1 billion to make wedding dresses for people."

When he said this, he naturally thought of the history of the development of generic drugs in India. In later generations, India has become a purely generic drug country. Their national policy requires pharmaceutical companies to force authorization. Of course, in India, this system and regulations are not yet perfect.

Therefore, Yang Rui once again said in the form of prediction: "The development of the generic drug industry with the goal of original drugs is fundamentally different from the development of the generic drug industry with the goal of generic drugs. Japan is currently taking the previous path. At first sight, the Indian government is currently taking the next path, and it is expected to have considerable results..."

Immediately afterwards, Yang Rui stated the policies implemented by the Indian Council and said: "I estimate that India's generic drug industry can be expanded. However, the making of generic drugs will ultimately be limited to original drugs, and policy changes , Even changes in the international format will affect their industry, and it is not very suitable for China to study."

What the three big brothers want to hear is naturally the content at the national level, and Yang Rui's answer is also extremely attractive.

The pharmaceutical industry is a trillion-dollar industry in the world, and it is one of the largest industries. Moreover, its consumption of resources is extremely small, and it belongs to the category of extremely high value-added. Countries with a little bit of thinking can't wait for it. See it.

"So, if China is to develop with original drugs as the goal, do you think it is feasible?" Tang Gong asked about the specific steps, which are already at the level of policy consultation.

Yang Rui thought about it for a moment and said: "In general, I think four or five five-year plans should be able to see results. However, the cost of drug research and development is so high, and the company should be the main body and the benefits should be fully considered. Otherwise, no matter how rich the country’s finances are, it will not be able to support such a long and huge investment. For now, I think the implementation of GMP is a good strategy."

"GMP is the production quality management practice?"

"Yes, GMP is not an end, but a means. The main problems of domestic pharmaceutical companies are still too many. Whether it is the experience of the United States, Japan, or Northern Europe, pharmaceutical companies are bigger and stronger. Mergers Restructuring is also an inevitable way. There are currently more than 4,000 pharmaceutical companies in China. There are too many. Generic drugs that make generic drugs are not evenly distributed. The development of original drugs..." Yang Rui laughed twice, then shook his head. Constantly said: "I think it is a lot for domestic pharmaceutical companies to keep around 100. In the short term, it is necessary to control the scale of pharmaceutical companies to 1,000."

Historically, the implementation of the GMP system has reduced the number of pharmaceutical companies in China from 4,000 to 2,000. Yang Rui’s attitude is naturally more determined and radical. After all, the current small pharmaceutical companies with an annual output value of tens of millions of RMB Basically, they are caused by local protection. There is no market competitiveness. Even some pharmaceutical companies are currently in a state of loss. Under the situation that the government provides raw material protection and the procurement of drugs is government-based, it can still be Incurring losses, let alone value for such pharmaceutical companies, all they produce are fake and inferior products, but patients have no right to choose and resist.

The three tycoons couldn’t help but fell into deep thought, and Qiao Gong suddenly felt his spirit. He was in favor of large-scale mergers and reorganizations of domestic companies. Starting from pharmaceutical companies, it was a lawful incentive. If so, And being able to implement the shutdown and transfer of the entire industry is naturally more in line with his governance philosophy.

The governance philosophy of Tang Gong and Lao Li should be more peaceful, but Yang Rui's statement has shaken their positions.

Indeed, 4,000 pharmaceutical companies are indeed too many.

China's economic policy has always tended to be large and comprehensive, because under the planned economy system, small and beautiful companies almost do not exist, and it means that management costs are too high to be achieved.

China’s railway industry, heavy machinery manufacturing, petroleum, finance, communications, aerospace and other fields are all dominated or monopolized by several companies. At present, they are all relatively well-operated industries, especially Compared with industries such as coal mines and textiles, the management efficiency and profit margins are not all good.

For the development of the pharmaceutical industry, 4,000 pharmaceutical companies are definitely not enough. It can even be said that the existence of 4,000 pharmaceutical companies has challenged the survival of the entire pharmaceutical industry. Now there are foreign outsourcing orders that make many pharmaceutical companies alive. It's quite moist, but how long can it last by relying on such low-end import and export?

Therefore, it is almost necessary to reduce the scale of pharmaceutical companies.

Tang Gong and Li Lao asked several questions in a row, and after Yang Rui answered them, they gradually fell into contemplation.

Master Qiao said in a hot iron: "Yang Rui, shutting down and transferring is a big proposition, you can talk about it too."

Yang Rui hesitated and said, "This is the content of management."

"You talk about pharmaceutical companies. The pharmaceutical industry is your business. Besides, didn't you have suggestions in this area before?" Qiao Gong sold Yang Rui to the stage without hesitation.

Yang Rui couldn't get rid of it, he hesitated, and said: "In my opinion, what pharmaceutical companies need most is capital, followed by technology and equipment. The demand for manpower is the lowest. Compared with the machinery manufacturing industry, the automation of pharmaceutical companies The degree can be raised very high. Therefore, although skilled workers are required, the number requirements are actually reduced. In other words, the most important financial integration is the merger and reorganization of pharmaceutical companies, followed by technical improvement and complementarity. Then there is the purchase and complementation of equipment, and finally, it is probably to divert a large number of workers."

Yang Rui did not use terms such as elimination or layoffs, because before the concept of "lay-off" was put forward, workers were a life-long occupation, and occasionally state-owned enterprises that were shut down and transferred also had to redistribute workers to work.

Nevertheless, diversion is still a cruel and unavoidable topic.

Qiao Gong had already thought about it. He looked at both Tang and Li and said: "I see, what Yang Rui said is very reasonable~www.wuxiaspot.com~ If we don’t do a pilot, we will use the production law to determine the violation of Beijing. How about the West Pharmaceutical Factory as a pilot project?"

"The scale of Jingxi Pharmaceutical General Factory is very large." Tang Gong looked up.

Qiao Gong just wanted to be big, and immediately said: "There are big benefits, and the problem can be fully discovered. Furthermore, the handling advice reported by the Ministry of Health is to shut down and transfer. This is a ready-made test material."

Tang Gong didn't speak, but Li Lao said: "I agree, but you can't simply shut down the matter, it's just to deal with it, and it's meaningful to deal with it."

"I agree, we can analyze it now." Qiao Gong came to the spirit, both eyes were shining.

...

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