Back To The Age Of The '80s

After Zhao Depei hung up the phone, he was in a daze. He understood every word Li Zheng said, but why couldn't he understand it together?

What do you mean, it is still possible to leave a place for Huaguo.When watching a movie in a movie theater, you can still reserve seats for people.

What experiment, what experiment produced results that could stop the debate in the American scientific research community and greatly promote the advancement of the Human Genome Project?Why hasn't he heard anything about it?

"Zhao...Principal Zhao?" Sun Bin said cautiously. He felt uncomfortable. He was only halfway through talking with Professor Li just now. Professor Li said that each of them can have an individual signature The first SCI paper!

Those are SCI papers. Now those who have published SCI papers on Huaqing campus can count them by counting on their fingers. He can already imagine the envious eyes of his classmates after he publishes the paper.

It's just that this achievement involves patents, so he's not sure what can be written and what can't. President Zhao, you should take your hands off the phone.

"Huh?" Zhao Depei suddenly recovered from his own thoughts. He saw Sun Bin who was looking at him cautiously, and pursed his lips. He had to figure out how to repeat what Li Zheng said to him Chen Anbang and those veterans of the Huaguo biosphere.

"Do your job well." Zhao Depei patted Sun Bin on the shoulder, and walked out of the laboratory quickly with Sun Bin's puzzled expression on his face. What he has to do now is to write the so-called leave note with the reason for asking for leave first. find out!

Meng Jie and Lu Keke walked to Sun Bin.

"School...principal, it's...all right." After entering the ninth laboratory, Meng Jie began to become more confident because of his ability in biological research, and even talked more.

"It's okay, what can the principal do? Sun Bin, did Professor Li ask us to write the paper by ourselves just now?" Lu Keke stared at Sun Bin with burning eyes.

Sun Bin glanced at him, "The ears are really sharp. That's right, that's what the professor meant. This project of unlimited organ storage is called by the Western media as one of the tickets for the future medical industry, and the attention has always been high. The overall Project papers must be published in top international journals such as "Science" and "Cell". Although we are only responsible for a small part of the experiment, when this small part is written as an academic paper, the threshold for SCI papers can still be reached."

Luke let out a burst of cheers, "I feel like I'm dreaming!"

On the other side, Zhao Depei returned to the office, rummaged through the boxes, and finally found the leave note that Li Zheng was talking about.

Person who asked for leave: Li Zheng

请假日期：1986年5月25日到1986年6月18日

Reason for leave: To attend a biology conference on Long Island, New York

Heading to a biology conference on Long Island, New York? !

Cold Spring Harbor Laboratory is indeed in Long Island, New York. That's right, it's okay for the Human Genome Project experts to call it a biology meeting!But can't you be more specific! !

Zhao Depei clutched his chest, almost spurting out a mouthful of old blood.

"Xiao Chen, come here." He called Chen Anbang.

When Chen Anbang knocked on the door and came in, Zhao Depei was still holding the leave note in a daze.

"headmaster."

"Well, sit down." Zhao Depei said, and handed the leave note in his hand to Chen Anbang, "Look, this is the leave note Li Zheng used to ask me for leave after the establishment ceremony of the Huaqing Awards."

Chen An was at a loss. He was so busy these days that he was dizzy. Mr. Meng left. As Mr. Meng's disciple, he received the network resources of Mr. Meng before him. The Human Genome Project was like dripping in a pot of boiling oil. The water inside caused the entire Huaguo biological circle to stir up. Recently, he has been busy using the contacts in front of Mr. Meng to make the Huaguo biological circle make its own voice internationally.

At this time, Zhao Depei asked him to see the leave note?

Chen Anbang is a good-natured guy, so if Zhao Depei asked him to watch it, he would just watch it.At this glance, he saw that the doorway was coming, the Long Island Biology Conference in early June.

"Human Genome Expert Meeting?!" Chen Anbang stood up abruptly, his voice slightly high because of surprise.

"Well, that's right." Why did Chen Anbang see it at a glance, Zhao Depei muttered to himself, it's not his fault, he's not from the biology circle, he's not that sensitive.

"Li Zheng attended the meeting of human genome experts? Then what did he say, did you tell him what we mean?" Chen Anbang looked at Zhao Depei nervously, clutching the fake note tightly in his hand, and tightly gripping the corners of it. Very wrinkled.

"He, he said that now is not a good time for China to participate in the Human Genome Project..." Zhao Depei repeated Li Zheng's words to Chen Anbang.

After hearing this, Chen Anbang was speechless for a long time.After a long time, he stood up and said, "This is not something I can decide. I want to discuss it with them."

Not to mention the biologists in China who had been arguing for half a month after hearing the news, Li Zheng and Ruiz finally found a suspected target a month later.

EGFR

“突变集中在EGFR激酶区的18-21号外显子。主要突变情况EGFR的外显子序列18突变G719等；19缺失15BP、19BP、12BP、9BP；20，T790M插入；21突变L85SR等。根据500组对比实验，18、19、20、21突变发生率分别是5%、45%、5%、45%。报告完毕！”理查大声说道。

Ruiz quickly grabbed the data analysis report in Richard's hand, "Li, I have a hunch, this must be what we are looking for!" He said excitedly.

Of course Li Zheng knew that EGRF was the target they were looking for.

Li Zheng chose this target after deliberation. He is one of the most obvious and easy targets to be discovered under the current conditions. At the same time, this mutation is commonly found in Asians and non-smokers. 60%, this is the most important purpose for him to start this project first.

"Obviously, exon 19 deletion and exon 21 mutation L858R are the two most common EGFR mutations. One of us is responsible for one, and we meet every two days to share information, is that okay?" Li Zheng said in a deep voice. Said.

Ruiz nodded vigorously, "Okay, my friend, let's start right away!"

Once the target is found and the corresponding inhibitor is studied, there will be a direction.Both of them are experts in anticancer drug research. Ruiz has studied lung cancer drugs for half his life, and Li Zheng is standing on the shoulders of giants.

In early 1987, the U.S. Department of Energy and the National Academy of Medicine allocated $550 as start-up funds for the Human Genome Project and announced the start of laboratory preparations.

On the second day after the U.S. Department of Energy and the National Research Institute announced the decision, the type 1 human epidermal growth factor receptor in Ruiz's laboratory passed the difficult biological experiment and officially entered the clinical stage!

"I got in touch with the state hospital. In just one week, 120 patients have signed up. They are all patients with advanced lung cancer, and many of them can no longer go to the field." Ruiz handed the registration materials to Li Zheng.

The cooperation between the two of them for half a year has already established a certain tacit understanding. Li Zheng flipped through a little, and said, "Choose sixty, and divide them into three stages according to the severity of the disease for clinical comparison."

After the clinical results of late-stage patients come out, it will be decided whether to conduct clinical trials for mid-stage or even early-stage patients.

"Yeah, okay." Ruiz nodded.

He put down the documents in his hand, with a tangled look on his face, he looked at Li Zheng hesitating to speak, and finally couldn't help but ask.

"Li, have you ever participated in the whole process of drug clinical practice? I mean not only clinical data analysis, but field participation."

Participate in the whole process of clinical medicine?It seems that there is really not.

When it came to Baminoxatin, he deliberately asked the Indian manufacturer to do human clinical trials. When it came to Taxine, his nerves were tense every day because of the war situation in Doman. Doman's army is intriguing, and there is no time to participate in the whole process.

The human drug clinical trial with the highest participation rate was probably the drug clinical trial of carbapenem antibiotics, because there was only one drug experimenter at that time, and he was his respected teacher.

As for the previous life, the third-party outsourcing has been well developed, drug researchers only need to visit occasionally, except for special circumstances, there is no need to participate in the whole process at all.

Seeing Li Zheng's silence, Ruiz understood his answer, "Li, you are amazing. Your academic level is very high, especially your experimental thinking, with clear logic and clear direction. You are a very amazing scientist. But you are still young after all. If you can't stand the next clinical trial, please tell me at any time, we are friends." Ruiz said solemnly.

Li Zheng didn't understand what Ruiz meant at first, but as the project team entered the state hospital, seeing the patients lying on the beds who hardly looked like living people, Li Zheng couldn't help but realize something.

However, in his opinion, Ruiz really underestimated him. As a biopharmaceutical person, this is something that must be experienced.

"Professor Ruiz, Professor Li, sixty applicants are here. They and their family members have signed the drug clinical agreement. This is their case." The doctor at the state hospital handed a stack of cases to the two .

Ruiz nodded, "I see."

Zhouli Hospital has opened up an entire floor as a clinical trial base for this drug, with two patients each having a room.Sixty patients were divided into three stages according to their condition, and the best ones could stand up and walk for a while.

Those in the middle can walk for a while with the support of others.

The worst one was lying on the hospital bed directly. I heard that even touching it hurts a lot.