Bai Zhanguang through the gate of the mansion

Biological medicine wants to make money, so biological medicine is the fastest way to make money!Moreover, his home is Baicao Hall, which sells medicines!Thinking back to his grandfather, Qi Ye developed a new glue-making method in Jinan, opened a shop to sell it, and then became very good in Jinan, which shows how much money medicine makes!

Besides, the impression he has left on his grandfather's side now is that he is reading medical books, learning medical skills, and researching out any medicines is not so obtrusive.So as a matter of urgency, he should develop and research what kind of medicine is better.

Well, after recalling it carefully, he found that around 1950, in 1951, tuberculosis had physical therapy.Then, in 1951, came the anti-TB drug isoniazid! In 1963, rifampicin came out, and the treatment of tuberculosis made epoch-making progress, and the global tuberculosis epidemic was quickly brought under control.

Tuberculosis, also known as "consumption disease", is not curable. (The following information is really from Baidu, (∩_∩))

How is isoniazid prepared?Bai Zhanguang searches for information.

Isoniazid is an anti-tuberculosis drug for tuberculosis, skin tuberculosis and so on.The product is a colorless crystal, or white to off-white crystalline powder; odorless, slightly sweet and then bitter; gradually deteriorates when exposed to light.The product is easily soluble in water, slightly soluble in ethanol, and very slightly soluble in methacrylate.The melting point of this product is 170-173°C.Invented in 1952, isoniazid revolutionized the treatment of tuberculosis.In the following decades of use history, although the tuberculosis bacteria infected by patients have developed drug resistance, most doctors still believe that it is an indispensable main drug for the treatment of tuberculosis.

In 1912, isoniazid was originally synthesized by Hans Meyer and Josef Mally, graduate students of the Department of Chemistry at Charles University in Prague (then part of Germany), during their doctoral dissertation in 1912.They are completely unaware of the enormous medicinal value of their products.After about 40 years of oblivion, researchers at Ross and Bristol-Myers Squibb in the United States and Bayer in West Germany independently discovered that isoniazid had potent anti-tuberculosis activity.

In 1915, clinical trials of isoniazid began in New York in 1951.

In 1952, isoniazid was first listed in the United States by Roche, with the trade name Remifen.

It is derived from the condensation of isonicotinic acid and hydrazine hydrate.Dissolve isonicotinic acid in hydrazine hydrate, add the previous batch of crude mother liquor, and distill under reduced pressure to 79-82°C (13.3-14.7kpa).Raise the temperature to 129-130°C and react for 3h.Add half the amount of mother liquor to the reaction solution for dilution, add activated carbon for decolorization, and filter.The filtrate is cooled and crystallized, filtered at about 10°C, and the filter cake is washed with crude mother liquor to obtain crude isoniazid.Then recrystallization, activated carbon decolorization, filtration, and drying to obtain the finished product.The yield is 90%.

Well, the drug will be on the market in 1952, and he needs to be faster to drive out isoniazid before these pharmaceutical companies.Oral isoniazid can cure the disease, and he can develop a drug named after himself, just like Qi Ye.

After making up his mind, Bai Zhanguang started to prepare professional tools, raw materials for synthesizing isonicotinic acid and experimental materials. He bought a large group of mice and rabbits, which made the people in the mansion think that he was crazy and said behind his back Gossip.

After Tang Youqiong found out, she educated the gossipers at home and went to Bai Zhanguang.

"Son, what have you been doing lately?" Tang Youqiong didn't enter her son's house, and there was a huge sign "No entry for idlers!", so she still didn't enter, so as not to be blamed by her son when she turned around. "Also keep mice!"

"Mom, your son, I'm doing something big. I'm researching a medicine, just like grandpa!" Bai Zhanguang was still in the mood to coax his mother. He took over someone's body, and he must bear the responsibility.

"Still researching medicine, just like the old man? Why haven't I heard that the old man invented the medicine to ask for mice!" Tang Youqiong didn't believe it, "You, you must be trying to make me happy."

"How come? Don't worry, Mom, you will know in a few days."

Bai Jingye let his son fool around, but he didn't care.

As for the others, while conducting experiments in the laboratory, Bai Zhanguang had to educate the servants at home how to take good care of his little animals, and he had no time to deal with those gossiping people.

Qiye also heard from Xiangxiu that his grandson, who has recently been reformed, is doing something, and that no one else is allowed to enter his yard. If he goes by himself or the servants who take care of small animals go to the yard, they have to wrap themselves in rice dumplings. inexplicable.The eldest daughter-in-law said that Zhanguang was researching drugs, but she didn't know if it was true or not?

The whole family gathers to eat together.

As long as everyone eats together, Bai Zhanguang will usually be there. After all, he is confident in his experiments, so he wants to show his presence in front of the old man. After all, the later clinical trials and the promotion of medicine depend on the old man.Well, hug the old man's thigh!

Qi Ye looked at Bai Zhanguang, his face was flushed red, and he was surprised: "Zhanguang, what's the happy event today? Look at you happy. You can't hold it back."

Bai Zhanguang put down his chopsticks, touched his face, "Grandpa, is my behavior so obvious?" O(∩_∩)O~~

"..."

"Nonsense!" Qi Ye thought it was an idiotic question.

"Grandpa, I wanted to tell you after dinner," Bai Zhanguang couldn't help it, "Ahem, today I successfully developed a drug and tested it on small animals. It really works."

Qi Ye was also interested, "Let's hear it, what kind of medicine? What kind of disease?"

"Well, I haven't figured out the name yet." Bai Zhanguang paused, making sure everyone was listening to him, "it's a medicine for tuberculosis."

Bang, Master Qi's bowl was overturned.

He "swiped" all of a sudden and stood up.He asked sharply, "Really?"

Bai Zhanguang nodded.

Qiye stopped eating, and walked directly to the door, saying as he walked, "Zhanguang, let's go, take Grandpa to have a look!"

Bai Zhanguang hurried out with him, leaving a whole room behind.It was very quiet in the huge room.

After a while, Tang Youqiong asked, "I, did I hear correctly just now? Lord, just now Zhanguang said that he has developed a cure for tuberculosis."

Bai Jingye nodded heavily, extremely proud, "Hahaha, he is indeed my son, he really makes me look good!"