I reach the pinnacle of life by learning

Yu Hanxi stared at the business card with a complicated expression.

But in the end, he accepted it.

Yu Hanxi replied indifferently: "It depends on the situation. If I happen to be free, I will go."

Qiao Yu smiled slightly.

The afternoon tea at Bernard's house is rich in variety and delicious in taste, making Wang Xiaoming, who has never seen the world, eat his belly round and praise it all the time.

The chef was so happy that he was happy.

Although there was an unpleasant episode in the middle, it didn't hinder Bernard's purpose of inviting Qiao Yu over.

He is a businessman, and his family business has been supplying medicine to the front line since World War II; what is going to be discussed is naturally the patent issue in Qiao Yu's hands.

Bernard spoke of the favorable conditions of the Merkel Group in a very casual tone: "Although the patent has not been approved yet, I believe it has only happened in the last one or two months. Do you want to cooperate with our Merkel?"

"I assure you, our Merkel's conditions are the most favorable. We are willing to spend 9000 million knives to buy patents, and you can get a [-]% share of sales profits. It lasts for ten years."

Bernard said very sincerely: "In order to get the approval from the board of directors, I worked hard for a long time to convince those old antiques. They all think that I want to cash out and divide the family property."

Qiao Yu didn't answer this question directly, but asked: "If it finally passes the FDA (US Food and Drug Administration) approval, how much do you plan to sell?"

Bernard obviously conducted an in-depth investigation, and immediately replied: "Hematopoietic stem cell transplantation can restore long-term stable hematopoietic and immune functions, so it is considered to be the most cost-effective gene therapy method, and it does not even require suitable bone marrow. There is a long-term market demand. After obtaining the patent, we plan to establish a specialized medical institution to collect blood samples sent by patients. And rely on repeated experiments to complete the expansion of autologous HSCs."

"For the purpose of technical secrecy, the construction cost of this medical institution may be much higher than that of conventional institutions. In addition, transportation costs are also relatively expensive. We plan to build a small airport near this medical institution... "

When the German was talking about business, his face was bright: "Although the initial investment is huge, Merkel is optimistic about the future market prospects."

A box of Gewei for the treatment of chronic myeloid leukemia costs [-] yuan, and patients consume one box a month.

In 2011, Greenway's sales reached 40 billion US dollars.

From the advent of the drug to the present, the net profit of Nuoan Pharmaceuticals is about 300 billion knives after excluding expenses.

Gewei only inhibits and delays the onset time, and cannot achieve the purpose of treatment.

Even so, because you can live if you eat it, you can only wait for death if you don’t eat it.

There are still people all over the world who are trying to save their lives.

The in vitro expansion of hematopoietic stem cells is different.

It can be said that if clinical trials are passed, blood cancer, like hepatitis B, will gradually fade away from the long river of human history.

"Based on the above situation, the price is tentatively set at 20 knives, and we are responsible for frozen transportation."

20 knives, equivalent to about 140 million Chinese currency.

Today, even if there is a suitable bone marrow transplant for a patient, the cost is around 50 if there is medical insurance in China.

In foreign countries, depending on the region, the general price is around 100 million.The price fluctuates, mainly depending on whether the rejection reaction of the patient is serious or not.

This price includes chemotherapy, first aid, bone marrow matching, surgery fees, and more.

Also, the transplant is not a one-off.Typically, two to three transplants are required.Before each transplant, chemotherapy is required.

But even if you want to spend money, you need a prerequisite: that is, you can find a matching bone marrow.

However, in vitro expansion of autologous hematopoietic stem cells is not used.It only needs to collect the original blood from the patient, let the stem cells differentiate into healthy hematopoietic stem cells, and transport them back to the body to cooperate with the treatment to achieve the goal.

This could save countless lives.

As the researcher of this technology, Qiao Yu is very clear about the cost of HSCs expansion in vitro.

Excluding basic equipment and labor costs, the price is 760 yuan and [-] cents in terms of the chemicals needed for the experiment alone.

If you wholesale from raw material merchants, there is a high probability that you can get another discount.

What is profiteering?This is profiteering.

Scientific profiteering permitted by law.

Borrowing ordinary people's blind worship of science to rationalize unreasonable profits, let tens of millions of ordinary people with mediocre income defend monopoly pharmaceutical companies with annual profits exceeding tens of billions.

Qiao Yu said: "Your conditions are already very favorable. In the past week, I have also received many olive branches from all walks of life. I have to say that the conditions provided by Merkel are the best."

Bernard had expected to experience some haggling.

As a capitalist, he certainly couldn't throw all his cards at once.The bottom line price given by the company's headquarters is about 5000 million knives, and a [-]% share.

He tentatively asked, "Why don't we sign the contract now?"

On the other side, whether it is Wang Xiaoming who is still eating, Zhang Kaiwei who is reading magazines, or Yu Hanxi who is playing Spider Solitaire with a computer, the tips of his ears will inevitably perk up.

However, Qiao Yu just shook his head.

"Sorry." He replied, "I didn't want to sell it for a price. I was just thinking that there are many patients who may not be able to afford the 20 yuan."

Because of language and nationality issues, I am afraid that many people, especially Chinese, still need to seek help from intermediaries.

At that time, the cost will be around 150 million, which is good.

How much is 150 million?

Maybe if you think about it carefully, it’s only a house in a second-tier city.

However, the domestic annual per capita disposable income is 21966 yuan.

Bernard was taken aback, then smiled and said: "Joe, you are so kind. I am afraid that the initial investment alone will cost hundreds of millions of yuan. It is impossible for us to do charity. This is turning the whole industry back, so that pharmaceutical companies have no Capital is used to develop new drugs, and there are still many unsolved problems in human history, and to solve them not only requires the wisdom of scientists; it also requires our money."

Qiao Yu hasn't heard others use "kindness" to evaluate herself for a long time.

He has been to the level of the big bourgeoisie, and he understands that the essence of capital is nothing more than layer upon layer of exploitation.

Even if the capitalist cuts the flesh here, he will earn it back by sucking other people's blood elsewhere.

If Qiao Yu agrees now, then he is just a ghost in the hands of the executioner.

It is unscientific to let pharmaceutical companies have no profit at all, or even pay back money.

However, in Qiao Yu's eyes, this kind of abnormal huge profits is also unacceptable.

Qiao Yu said: "Bernard. I have calculated that the number of leukemia patients worldwide is currently around 100 million, and the annual increase ranges from 4 to 8. In addition to leukemia, diseases that require hematopoietic stem cells also include progeria and thalassemia. Wait, that is to say, there are currently about 200 million people waiting for treatment in the world. Assuming that the construction cost is 5 million knives, plus transportation, promotion, labor and other expenses, it is calculated as 10 billion, and each patient only needs to crowdfund [-]. "

"But using the GARCH volatility model, the price can be as low as four thousand three."

Bernard frowned slowly: "But you can't guarantee that all these 200 million people will come for treatment."

"Yes," Qiao Yu said, with a feverish head, so he had to rub his eyebrows, "So I was thinking, if I give up the patent money, let the pharmaceutical companies sell it at a uniform price of 8000 knives, and after ten years Is it feasible to reduce it to $2000?"

The Spider Solitaire on Yu Hanxi's computer remained silent for a long time, and his face was thoughtful, as if what he was facing was not a simple pattern of Spider Solitaire, but a complex biochemical experiment.

After thinking for a moment, Bernard replied: "The profit is too low, and the period to recover the cost is too long. Pharmaceutical companies may prefer to wait for Gwei's option to expire to sell generic drugs, and they will not accept your proposal."

"And in this case, the major groups may instead unite to put pressure on you. At that time, even the FDA audit will not be able to pass... Joe, you don't follow the rules."

Qiao Yu sighed: "In 1984, Merkel's president Genos transferred the hepatitis B vaccine technology to Huaguo at a super low price of 700 million US dollars. I thought it might be the same in 2015."

"In fact, his words still hang on the first floor of our headquarters building, 'We should always remember that medicine is for people, not for profit.'" Bernard replied in a low voice, "But this I might not be able to decide on my own."

Qiao Yu can understand.

Such a long-established company with a century-old history is itself a behemoth. It is normal for the board of directors to have dozens of decision-making layers.A trivial matter may be tossed for several weeks due to internal interest disputes, and the efficiency is extremely low.

"I will disclose these conditions to the pharmaceutical companies that have asked about the price before." Qiao Yu replied, "Let the pharmaceutical companies choose freely. Next month, I will hold an academic report at Yanda University and invite interested companies. final negotiations."

Qiao Yu didn't intend to disclose it to the whole society, lest some companies feel like they were kidnapped by morality.

As for himself, he doesn't care much about fame.

After finishing speaking, Qiao Yu picked up the teacup on the small wooden table next to him, took a sip of water, and moisturized his somewhat dry lips.

Bernard felt a sudden pain in his forehead: "Our pharmaceutical company just earns a lot less, and you directly lose hundreds of millions... and you don't look like a person who is indifferent to fame and wealth, so I may find it difficult to understand your behavior .”

Qiao Yu replied: "My mother also has leukemia. It is inherited in the family, and I may have it too."

He is not short of money, and his material desires are not high.

Qiao Yu felt it was worth losing hundreds of millions and exchanging tens of thousands of lives.

What's more, if you didn't get the money, it's not a loss.

Bernard looked at him with his chin in his hand, and said meaningfully: "Even the profit is so clear, you have calculated it for a long time."

Qiao Yu swallowed slowly: "Not at all, I just calculated it in my head."

Bernard: "..."

You boys who are good at math are disgusting.

Because of Qiao Yu's resolute attitude, Bernard didn't talk about it again in the next few hours.

Instead, everyone is like ordinary friends, drinking and eating meat while chatting about gossip in the industry.

Yu Hanxi looked at the otherworldly fireworks, and was unexpectedly good at grilling meat.

"I grew up in the countryside in elementary school," Yu Hanxi said more than before, "I started chopping firewood and cooking at the age of six."

Yu Hanxi rolled up his sleeves, the exposed half of his arm was very thin.

Both of his parents died since he was a child, and his grandmother brought him up.When I was in junior high school, my grandma got cataracts and went blind.

Fortunately, because of his good grades, the principal of the town middle school managed to scrape together enough tuition fees for him to enter high school.

Yu Hanxi remembered very clearly that the tuition fee for one semester was [-], the accommodation fee was [-], and the board fee was [-] a month.

The school scholarship is 5000 a year, and the impoverished students are subsidized 1600 a semester.

Save it and send it to grandma for one thousand and two.In the third year of high school, there is no need to send it.Grandma fell asleep in the middle of the night and never woke up again.

He is a native of Jizhou Province. When he was a freshman in high school, Shi Wen, who had just become an associate professor at Jizhou University, came to give a speech in their high school and sponsored several poor students by the way.

Yu Hanxi is one of them.

So he still has no embarrassment to go back to see Shi Wen.

At eight o'clock in the evening, Qiao Yu took his two pendants and bid farewell to them in a friendly manner.

Bernard's parting hug was more enthusiastic than when he came: "Joe. You are a true scholar. Even if the headquarters does not accept your proposal, I hope we can be friends forever. You are welcome to come to my house next time to play."