I reach the pinnacle of life by learning

The two quickly agreed on a time and place to meet.

The location is in the genetic laboratory.

For this purpose, Professor Tan went back and changed into an Armani suit to show his respect for the Nobel Prize candidates.

Although the two were not in the same field before, since the other party can get a nomination, it is enough to show their status in the world.

The assistant assigned to him by Yanda University was recruited from Qiantang University. His name was Wei Caijie, and he used to do genetic research.But the academic response was mediocre.It can only be said that the tall one is taller than the short one.

If Tan Zirui hadn't returned to China, Wei Caijie might not have had the opportunity to work at Yanda University.

Assistant Wei said: "I heard that Professor Qiao went to Cold Spring Harbor before..."

Tan Zirui: "Three years. I know."

"But three years is too short. I know where Cold Spring Harbor is, and everyone who studies biology knows it." Tan Zirui said calmly, "I have been studying related fields since I was a graduate student, from biochemistry, Biophysics, mass spectrometry, and immunology have been learned until now, and I think I can be considered a very talented person if I can do what I am today. And it has been 18 years.”

In these 18 years, Tan Zirui can proudly say that he has not wasted a single day.

This is an endless road that can only go forward and cannot retreat. The roadside is full of gravestones of generations of scholars.

Some people have made more contributions, so their tombs are bright and beautiful, and they are covered with flowers and plants every year; some people only have some cold documents left in the world, and because time goes by, the past documents become obsolete, so they will never be buried again. Someone remembered.

Tan Zirui didn't want to be cannon fodder on the road.

"Do you know what I mean?"

Wei Caijie nodded, "Understood."

After two years in the afternoon, Tan Zirui finally met Qiao Yu.

He had seen Qiao Yu's photo before, and knew that he was a very handsome young man.

But Tan Zirui didn't expect that the other party was so... tall.

Qiao Yu, who is 1.8 meters three, will not be submerged in the crowd even if he is standing in Europe and the United States.

Professor Tan, who is only [-] in height, feels very heartbroken.

This may be because he had to look up at Qiao Yu.

"Hi, I'm Qiao Yu. Nice to meet you."

Qiao Yu didn't come alone, he was accompanied by Director Wu, Wang Xiaoming and Assistant Teacher Wang who also had the same pendant.

Apart from Wu Gang and Zhang Kaiwei, this is basically his entire team at Yanda.

On the other hand, Tan Zirui has not only three professors under his banner, but also five or six graduate students or doctoral students under each professor, adding up to more than 20 people, which is a huge momentum.

Before Tan Zirui moved, the eyes of the graduate students recruited by Yanda behind him were already shining, as if they were going to faint from excitement.

It was clearly a friendly academic exchange, but Qiao Yu's every move felt a little bit like an idol meeting.

Qiao Yu even waved to the researchers behind him, signaling them to be calm.

Tan Zirui looked annoyed.

He suspected that this group of graduate students had forgotten who was paying them.

Tan Zirui calmed down: "Tan Zirui, you can call me Kevin. Invited scholar of the Finnish International Cancer Research Center, special reviewer of ACS journals, former researcher of Cambridge Institute of Gene Therapy, currently PI of Yanjing Institute of Life Sciences, Yanda Biological Sciences Distinguished professor of the academy, research fields are receptor structure and signal transduction, cancer metastasis and gene transduction. In 2011, he was nominated as a candidate for the Nobel Prize for his discovery of microRNA, the key regulator of p53 protein."

Tan Zirui thought that at his age, it was amazing to be able to get to this point.

But I'm afraid that Qiao Yu doesn't know how awesome he is, so that he has to show off his position in a long and cumbersome manner, just like a male bird showing off his feathers in courtship season.

Qiao Yu waited for him to finish speaking, and said directly: "I read the papers you published in the last six months, and found that you seem to be researching the field of non-coding RNA recently."

Tan Zirui was a little surprised.

After all, in his script, this kind of speech should start with himself, and then start a series of attacks from this conversation.

"Yes, indeed..."

"So your genetic laboratory at Yanda University is also continuing this research?"

"Yep……"

Specifically, the experiment that Professor Tan is doing now is called "Study on the mechanism of small ribonucleoprotein particles regulating the binding and movement of non-coding RNA on chromatin".

Small ribonucleoprotein particles reside in chromatin and participate in the regulation of chromatin structure, transcription, and RNA processing.But how it works is still an unsolved mystery in the biological world.

Of course, there are many unsolved mysteries in the biological world, not bad for this one.

But solving this mystery and publishing a CNS paper is still no problem.

Professor Tan knows that the country pays great attention to publishing papers on CNS. As for whether the specific content of the research is useful or not, and how much it costs, it is not very important-most leaders do not understand the significance of this paper of.

They just say "Yeah, ok, ok!".

Originally, the research for the past two months went smoothly, but Professor Tan got stuck at the door.

Among the many non-coding RNAs, long-chain RNA is the most suitable sample for this experiment, because long-chain RNA contains more recognition sites after transcription, allowing small ribonucleoprotein particles to bind more stably to genes fragment on.

However, when constructing the model, most of the positioning signals in the long-chain RNA disappeared without a trace.

Professor Tan was puzzled by this, so he specially changed several kinds of long-chain RNAs for experiments.

While chatting, Tan Zirui had already forgotten the purpose of wearing a suit today.

He put on a white coat, entered the laboratory with Qiao Yu, showed him the half-made long-strand RNA transcription map, and mentioned his confusion by the way.

Of course, Professor Tan's original intention was to show off his muscles to Qiao Yu, so as not to keep leading the conversation away from this young man.

But he did not expect that after listening quietly, Qiao Yu pondered for a moment and replied: "Use antisense oligodeoxynucleotides to induce protein degradation and inhibit the function of small ribonucleoprotein particles and core protein components SNRNP70."

Because Qiao Yu's words were so sudden, Tan Zirui even froze on the spot, and it took a long time before he understood what the other party meant.

He was silent for a moment, and said to the graduate students behind him, "Go get it."

The graduate student hurriedly took out the required consumables from the drug management room, and completed the experiment under the watchful eyes of the two bosses.

It's also hard for him not to shake his hands, but to succeed in one go.

Next, the conversation between Professor Tan and Professor Qiao entered into a field that the graduate student could not understand very well.

He couldn't help but let go of his thoughts, recalling the braised pork that he ate in the cafeteria at noon...

There are five student canteens in the school, and there are several outsourced canteens.

Recently, the Second Canteen has a new team of chefs. The head chef is from southern Shonan, and the braised pork is simply a masterpiece.So extraordinarily gunslinger.

Five yuan of braised pork, a spoonful full, feeds the students all mouths full of oil.

It was already five o'clock in the afternoon, because Qiao Yu and Tan Zirui had been fighting each other with their professional skills, so the twenty or so people in the laboratory didn't dare to eat.It looked like the two would fight each other for hours.

The little researcher sighed, thinking that the braised pork tonight probably had nothing to do with him.

And at the front, Qiao Yu and Tan Zirui had changed from academic brawls to commercial brawls.

Professor Tan said: "Before, I was prejudiced. I felt that it was impossible to study a subject thoroughly within three years."

Qiao Yu: "You're welcome, three years is really short, and I'm still inexperienced in many areas. But I'm so clear about your experiment because I did it in Cold Spring Harbor before."

Professor Tan's smile suddenly froze on his face.

Qiao Yu recalled: "It should have happened a year and a half ago. At that time, I followed Professor Martin to study the metastasis mechanism of CAR-T in cancer cells. Because I couldn't move, I had to do something else to change my mind. relax for a moment."

Professor Tan: "...then why didn't you publish the paper?"

Qiao Yu said very sincerely: "I didn't think about it. At that time, my mind was full of cancer metastasis. But after graduating from Cold Spring Harbor last week, I brought out the relevant materials, and I was going to submit them for a review."

"I didn't expect it to be such a coincidence."

Qiao Yu turned his head and waved to Wang Xiaoming.

Wang Xiaoming stepped forward and handed over a printed thesis booklet.

"Professor Qiao has already submitted this paper to Nature. Please correct me."

Tan Zirui felt a lump in his throat for no reason.

He took the paper stiffly, and quickly flipped through it.

Everyone has done similar experiments, so the data and images in the paper are very familiar.

If Qiao Yu hadn't just returned to China this week, Tan Zirui would have suspected that there was an inner ghost in the laboratory.

The other party's thesis is written in English, as Kevin Tan's first language, there is no dyslexia.

Because of this, he can understand at a glance the weight of this paper.

After a long silence, Professor Tan had no choice but to say, "Sorry, I'm going to the bathroom."

Professor Tan was a crying bag when he was a child.

At that time, he didn't like to study, and he played wildly outside every day. His father used a three-finger-wide rolling pin to make dough.

His father was beating someone, panting heavily, his eyes were red, and he said viciously: "If you want to get ahead, then learn from me!"

When he was beaten, Tan Zirui was tough and would not cry.

But afterwards, hiding in the bathroom at home, counting the injuries on my body, I couldn't help sobbing.

Because of holding back his breath, he was finally admitted to a public middle school from the church primary school, which became one of the turning points in his life.

He was the only person of yellow race in the class, short and thin, and made more malicious jokes. Tan Zirui could only pretend he didn't understand, and giggled along with him.

After laughing, I secretly went to the school toilet to cry, not daring to make a sound, so as not to be laughed at through a door.

But that was all a long time ago.

As a mature middle-aged man, the current Professor Tan generally does not cry.

Back then, when his wife left with the child, he didn't cry, since the child wasn't his own anyway.

Later, when he was nominated for the Nobel Prize but didn't win, he didn't cry, anyway, he knew he couldn't be selected.

But now, Tan Zirui's eyes were red in the cubicle.

He feels he has been cheated.His father said that it is impossible to cultivate good scholars in China; when he was studying for a master's degree, his advisor said the same thing; and later when he was working, his colleagues said the same thing.

After a long time, Tan Zirui also believed in this.He came to TOP University and felt that he would be the No.1 gene therapy in China from now on.

As a result, Qiao Yu came out halfway.

It's okay to be taller than him, and he's 15 years younger than him.

What was he doing when he was 25?It seems that he has just graduated from Harvard and is going to Cambridge as a teaching assistant.

It is already considered good, and it is also a winner in life in the eyes of many people.

But people are afraid of comparison.

This kind of frustration caused Tan Zirui's heart to be torn apart.

He is a person who is unwilling to face failure, but willing to admit failure.

Tan Zirui opened the paper reel next to it, trying to wipe his tears and nose, but found that some ugly researcher didn't install a new one after using it.

"Shit." He cursed under his breath.

Professor Tan fished in the pocket of his white coat, only to find two used pH test strips.

He had no choice but to open the door.

In the end, it was so sudden that Qiao Yu just walked in from the outside.

Qiao Yu glanced over his reddened eye sockets, and explained: "You haven't come out for a long time, Director Wu entrusted me to see if you need any help."

Professor Tan replied weakly: "No need, thank you."

He turned on the faucet and slapped the cold water on his face.

"Don't look at me like that, well, I admit that you may be better than me in some aspects, but I..."

will not give in!

Fighting spirit was rekindled in Tan Zirui's eyes.

So what if he failed once, he will stay at Yanda for four years, and he doesn't believe that he will always be crushed by Qiao Yu in these four years.

Qiao Yu asked: "Since you don't need to do the experiment in hand now, and you don't have any new subjects in a short time, would you like to come to my laboratory to help?"

Tan Zirui asked: "What do you do in the laboratory?"

"Car-T cells and related gene therapy."

"Study targeted drugs?"

"Ah."

Tan Zirui was silent for a moment, then continued to wash his face.

Damn, are you crazy?

It is true that targeted drugs are a hot field of genetic biotechnology, but in more cases, laboratories in various countries invest a lot of money, and then waste money in vain.

In Tan Zirui's eyes, rather than chasing hot spots, the country is more suitable for carrying forward basic biology with peace of mind.

But the person who said this was Qiao Yu.

Tan Zirui: "Okay, I'll see what tricks you want to come up with."

The author has something to say: the academic content in the article has a reference "U1snRNPregulateschromatinretentionofnoncodingRNAs", first published in "Nature".

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Try to be as rigorous as possible, and if you are not rigorous, you will not get the law. Just think that the laws of life in the parallel world are different, and you will feel sick when you check the information.