Sleepless Doctor

"Wu, I don't want to listen to the final conclusion, can you tell me the most critical theory?" Rodriguez asked.

"My research, the last step-found that the deep brain may be able to reset the unstable pattern of neuronal oscillations in patients with Alzheimer's disease, especially the hippocampal θ rhythm may play an important role in learning and memory."

"..."

"The veterans don't die, they just slowly die." Wu Mian said, "In fact, the cortical cells are not dead, but the neurons oscillate in an unstable pattern."

"You have to use quantum theory to solve..." Rodriguez murmured.

"No, it's just inspired." Wu Mian said, "you will know after reading the final result. The treatment is not as difficult as imagined. The key lies in positioning. Positioning depends on your genius conception— -DST surrounds the matrix gradient system."

Rodriguez was silent.

Neurons oscillate and appear unstable patterns. This kind of sentences and narrative methods often appear in quantum physics.

However, magnetic resonance is a product of classical physics, and has nothing to do with uncertain quantum physics.

"Rhodes, in our previous study, we conducted bilateral low-frequency electrical stimulation of large cells of the basal nucleus in rats, and found that the selective food intake of rats was significantly increased. After electrical stimulation, nerves appeared in the prefrontal cortex, hippocampus CA1CA2CA3 and ventral dentate gyrus. Yuan activation."

Chu Zhixi went to pick up the patient. Wu Mian took advantage of this time and said to Rodriguez, “The large cells of the basal nucleus on both sides are related to the process of memory formation, and this process is mainly through the projection of the large cells of the basal nucleus to the extensive cortical area. The realization of cholinergic neurons was confirmed by a number of subsequent studies."

"Cholinergic neurons, what a wonderful vocabulary."

"Wu, what then?"

"Then it's a trade secret." Wu Mian said with a smile.

"..." Rodriguez really wanted to rush forward, and beat Wu Mian fiercely with his fist.

If it wasn't that he couldn't beat him, he must have rushed to do so early in the morning.

Either don't say it, or finish it if you want to say it, but he actually said the most important point, and then stopped abruptly! Rodriguez almost didn't spray a mouthful of old blood.

"Look at you, my old friend, don't have such an expression." Wu Mian said, "Then I will say more, as a sincere invitation to you."

"This is not an invitation, it's coercion! If I come to you, I will receive a letter from General Medical's lawyer the next day!" Rodriguez said angrily.

"Neuron proliferation-entorhinal zone: After electrical stimulation of the entorhinal zone in rats, it was found that it can induce the proliferation of hippocampal dentate gyrus neurons, and at the same time, the spatial memory function of mice is improved, and..."

"And what?"

"And I found that the improvement of spatial memory function can be antagonized by temozolomide."

Memory, this is the forbidden zone of neurology!

Has Wu's research started to touch the restricted area now? And it's not touch, it's that further research has been done, and even antagonistic drugs have been discovered.

"Electrical stimulation of the prethalamic nucleus can also induce neuronal proliferation in the rat hippocampal dentate gyrus. Neuronal proliferation appears 24 hours after short-term electrical stimulation, reaches a peak on the third day, and can last for 4 weeks. The intensity of proliferation is related to the frequency of stimulation."

"Rhodes, do you know what this means?"

"I don't know if I can treat Alzheimer's disease, **** it, your habits have infected me with Alzheimer's disease!" Rodriguez complained and continued, "But it can already prevent Alzheimer's disease. , Wu, can I understand that?"

"Yes." Wu Mian said, "The Tang team in California first gave the Rett syndrome disease model to fornix electrical stimulation, which can significantly improve the spatial cognitive and memory function, and can return to the normal level of animal cognitive function."

"When did this happen?"

"It was published in the journal Nature 13 months ago."

Rodriguez shrugged his shoulders. He is just an engineer and does not study the basic theory too deeply.

"That is to say, deep brain electrical stimulation can promote the release of nerve growth factor; it can promote the proliferation of neurons in the subgranular area of ​​the dentate gyrus; it can change the electrical activity of hippocampal neurons; it can promote the release of acetylcholine. A theoretical pathway has formed a closed loop, as long as If we can locate it, we can try to treat Alzheimer’s."

"It's Alzheimer's disease!" Rodriguez emphasized.

"It's all the same, you know what I'm talking about." Wu Mian said, "but the research on brain networks is still at a relatively backward stage, but that is the past. From now on, none of this exists."

"Are you really sure?"

"Of course, Rod." Wu Mian said, "What I want to show you is the miracle of breaking the cocoon and transforming the butterfly."

"Broken the cocoon into a butterfly?"

Obviously, Rodriguez could not understand the beauty of Chinese. Wu Mian’s words translated in English were not so clever and vivid~www.wuxiaspot.com~ Wu Mian did not continue to explain, but played back the magnetic resonance images of the small vegetative patient.

This time it's the full version, not the processed version that Jack Jones saw 36 hours ago.

The brain tissue below the hypothalamus is highly active, but the more outward, the worse the activity. It is like a tree, a tree standing in the cold winter of Siberia, with only the trunk and some branches.

It seems to have died and has no life.

The three-dimensional image is slowly rotating, and the gray outer layer resembles a silkworm cocoon, and the inside is empty.

"Wu, why is it so beautifully made? At least 30% of the system's operating speed was wasted!" Rodriguez complained.

"Rhodes, this is the commercial value. Not only you and I can understand, at least Jack can understand to be successful." Wu Mian looked at Jack Jones and said.

"Since 1985, Professor Turnbull has used basal nucleus electrical stimulation to treat dementia. This is not a new technique. It's just that all research has stopped at positioning and has not made breakthrough progress."

"Wu, why?"

"Because...their surgical techniques and positioning are very rudimentary." Wu Mian said frankly.

"I regret what you said."

"The targets of the hypothalamus and fornix nucleus are located below the lateral ventricle, and the front of the third ventricle. The implanted electrode must pass through the lateral ventricle. Since the tip of the implanted electrode is thicker than the microelectrode, the microelectrode should be implanted after recording. When the electrode passes through the lateral ventricle wall, the tip is likely to slide along the lateral ventricle wall, which affects the accuracy of the target."

"There is no accuracy in itself, and it is affected by surgical errors, so the effect can only be unsatisfactory. Everything is taking a chance. This is my summary of the past."