Back in 2002 as a doctor

"do not know."

Xiao Kai was a little confused by what Zhou Congwen said, so he poked his head in the back seat and asked, "Professor Zhou, do you really have this disease? Are you kidding me?"

Zhou Congwen nodded, but did not answer Dean Xiao's words, but continued, "Second, do you two know what aristolochic acid is?"

Director Han and Xiao Kai shook their heads at the same time.

It is now 2003, and Zhou Congwen only remembers that Zhu Yu published the report this year, but he does not remember the exact time.

In his last life, Zhou Congwen was still struggling with pneumonia and femoral head necrosis, so he had no time to pay attention to these.

"Aristolochic acid is a nitrophenanthrene organic acid compound that naturally occurs in plants of the Aristolochiaceae family such as Aristolochia and Asarum, and these plants have been widely processed by traditional Chinese medicine for detoxification It is used as a native medicinal material."

"In the study on the toxicity of aristolochic acid derivatives to porcine renal tubular epithelial cells, it was found that the toxicity of each derivative is related to its chemical structure.

Nitro is the main toxic group in aristolochic acid derivatives, and the presence of methoxy and hydroxyl can further enhance the toxicity of aristolochic acid. "

"But no matter how strong or weak it is, there is no doubt that aristolochic acid is harmful to the kidneys." Zhou Congwen said firmly.

"Woo~~~" Director Han let out a long breath.

Xiao Kai was blindsided by what he heard.

"The Chinese herbal nephropathy just mentioned is also caused by aristolochic acid." Zhou Congwen continued, "Its damage is at the DNA level."

"Uh……"

DNA level, this is a bit scary, Xiao Kai, and even Han Chu didn't expect it to be like this.

"Aristolochic acid forms aristolactam-DNA adducts during renal metabolism.

This adduct substance is stable in nature and difficult to degrade, and will exist in the kidney for a long time, continuously damaging the patient's renal tubules, resulting in renal function damage and inducing cancer. "

"The kidney damage caused by it cannot be recovered, and it is an irreversible reaction. Dean Xiao, remember the patient who ate red sugar cane we met last time."

Xiao Kai's face was a little pale, and he nodded.

"How is the patient?"

"Fortunately, although it's not very serious, there are still some neurological symptoms. It's hard for my family to accept it. I persuaded it for a long time, and finally I reluctantly agreed." Xiao Kai vaguely explained the matter.

But in the case of Red Heart Sugar Cane and Fengming Xiehuo Pill, Zhou Congwen mentioned the word irreversible.

Once it is irreversible... the consequences can only become more and more serious.

"Aristolochic acid probably also belongs to this category, and very small doses can cause renal failure in sensitive patients.

Large doses of aristolochic acid directly cause acute tubular epithelial cell necrosis leading to renal failure.Low dose intake may also cause irreversible damage to the kidneys. "

"That is to say, there is no safe dose of aristolochic acid. As long as it is ingested, it will cause irreversible damage to the human body."

"I'll just say it!" Han Chu slapped the steering wheel.

"Han Chu, drive hard, safety first." Zhou Congwen was taken aback.

"Don't worry, I'm an old driver, so I know it well." Director Han said so, but with a correct attitude, he held the steering wheel seriously.

"Professor Zhou, it's indeed about Fengming Xihuo Pills, right!" Director Han said.

"Well, even if there is no kidney failure... If Director Han is interested... forget it."

"what happened?"

"Aristolochic acid has an extremely long incubation period, which greatly increases the probability of patients suffering from kidney disease and upper tract urothelial cancer." Zhou Congwen said, "If you are interested, you can check the medical history of all patients with kidney disease and ureteral cancer in the Second Hospital of Medical University , See if you have taken this medicine orally."

Han Chu finally knew why Zhou Congwen said let it go.

I am just the director of medical affairs, and I did some things naturally in order to avoid a lot of trouble.But if you really let yourself do academic research, forget it.

But if you don't do this by yourself, you can go to the Department of Urology and Nephrology to do it. Director Han instantly thought of a few familiar faces.

"Professor Zhou, so powerful." Xiao Kai said with lingering fear.

"Is it Professor Zhou who is more powerful, or aristolochic acid?" Zhou Congwen asked.

"Uh... it's aristolochic acid that is powerful...Professor Zhou, you are also powerful." Xiao Kai touched his head and said truthfully, "But I heard that in traditional Chinese medicine, the monarch and his ministers assist and envoy can reduce the toxicity of neutralizing drugs."

"It's not good for aristolochic acid." Zhou Congwen said, "If I remember correctly, there are already 10,000+ victims in the country. Irreversible is irreversible. Among natural plants, I have never heard of anyone who can fight against it. Aristolochic acid reacts and neutralizes the poison."

"10,000+?!"

"Well." Zhou Congwen said, "In 1991, the academic circles discovered that Chinese herbal medicines containing aristolochic acid caused kidney failure. Since then, Belgium, Britain, France, Japan, and the United States... have successively banned Chinese herbal medicines containing aristolochic acid.

In 2000, the WHO even issued a special warning about aristolochic acid herbal medicine causing kidney disease. "

"It's not that traditional Chinese medicine is bad. Let's talk about the facts. We're talking about aristolochic acid."

Director Han glanced at Zhou Congwen, he didn't know why Zhou Congwen repeatedly emphasized this point.

Without the future, Director Han and Xiao Kai would naturally not know Zhou Congwen's mental journey.

But it doesn't matter, the toxicity of aristolochic acid has enough data to support it.

"What is that containing aristolochic acid?" Xiao Kai asked.

"Guan Mutong." Zhou Congwen said, "There are other things, but what Fengming Xiehuo Wan contains is Guan Mutong."

"Is it just diarrhea, and then there is urinary tract infection or something. I have always doubted the concept of getting angry by itself, without data analysis and molecular formula verification. Let's not say whether it is right or not, but whether it is necessary.

Get angry, can't you eat other things, you have to eat Guan Mutong. "

"Professor Zhou, you are right!"

Director Han immediately agreed.

"So, Han Chu, you did the right thing. It seems that Fengming Xiehuo Wan has been changed into a prescription drug, right?"

"Yes."

"Then let's not open the clinic. Even if there is no recall, the manufacturer is unwilling to accept the loss, so it will rot in the warehouse."

As he spoke, Zhou Congwen's voice became softer, as if he was muttering to himself.

Xiao Kai imitated Shen Lang and pricked up his ears, but only heard the second half of the sentence - God knows, what a joke.

What did Professor Zhou say?Xiao Kai was stunned.

Chapter 1126 Big Bad Wolf

When he came to the hotel, Director Han didn't ask for a single room, but sat in the lobby.

Zhou Congwen snickered. Director Han must have done enough homework, and even asked the director of 912 Medical Affairs, and maybe asked his boss's preferences.

This ability to concentrate is enough to make people admire.

Zhou Congwen was not interested in eating and drinking, so he didn't order food, but had nothing to do to look at the people around who were eating and changing glasses.

The boss especially likes to watch the fireworks in the world, so Zhou Congwen also likes it.

Soon the door of the restaurant was pushed open, and the young man looked around, looking for Director Han.

Sales are not easy, but Zhou Congwen has no intention of giving him a hand.

As for Fengming Xiehuo Pill being banned from being prescribed by director Han overtly and secretly, and targeted by director Han, Zhou Congwen thought it was a good thing.

Just like arsenic can cure tumors, it takes at least one research group to devote a lifetime of energy, plus a little luck to achieve results.

If you keep holding on to what is left unfinished, let alone making progress, a person like Wang Chengfa who cherishes himself with his broom can make countless prescriptions that have already formed disappear into history.

After Director Han finished ordering, he saw Zhou Congwen looking at something smiling, he followed Zhou Congwen's gaze, and his face immediately fell down.

"Hehe, is that young man very persistent?" Zhou Congwen said with a smile.

Director Han snorted coldly, turned around and waved.

To those who don't know, the chubby little hands are like Doraemon, who can take out something new from the pocket anytime and anywhere.

But anyone who knows Han Chu knows that he just looks harmless to humans and animals.

The young guy originally wanted to press money at the front desk to pay for Han Chu and buy a chance to speak.

But when he was talking about this with the cashier, he saw Han Chu waving to him, he hesitated for a moment, and walked over boldly.

"Han Chu." The young man bowed, his head almost touching his feet, humbled into the dust.

"Sit down." Director Han was unexpectedly gentle.

The young man's expression relaxed a little, but Zhou Congwen knew that he was in serious trouble.

If Director Han was just doing things on instinct to avoid some medical disputes and troubles before, then Director Han must have made up his mind to kick Fengming Xiehuo Pills out of the Second Hospital of Medical University after explaining himself in the car.

Zhou Congwen was able to get along happily with Director Han in his last life because although he has countless shortcomings, his advantages are also very clear-at least he is a qualified medical director and a deputy director in charge of clinical affairs.

He has business to do.

"You have just joined the work not long ago." Director Han asked gently.

"Yes, I've been working for less than a year." The young man said awkwardly, "Director Han, you must be arrogant and treat me like a fart. It's not easy for me, you..."

As he spoke, countless sorrows and depressions flooded his heart, with a mournful face, as if he was about to cry in the next second.

"There's still a lot of experience in society. I'm just trying to solve a problem for you today. The real article is yet to come." Director Han said leisurely.

The young sales manager was taken aback.

"Since you've come along, it's not easy, so I'll give you a chance." Director Han said.

The weeping expression on the young man's face melted a little bit, and a little relief and relief emerged.

Zhou Congwen sighed in his heart, he still didn't know what he was going to face.

"Tell me, what is the meaning of avoiding spicy food in the instructions of the medicine." Han Chu asked.

The young salesman knew that this might be his last chance, or it might be that Director Han was going to spare his life by asking an extremely simple question casually.

He immediately said seriously, "The five flavors of Chinese medicine: pungent, sweet, bitter, salty, and sour. Xin refers to the common spicy, and Gan refers to the common sweet...the so-called pungent and spicy have the same meaning."

"Okay, don't go on talking."

The young salesman had just started, but was stopped by Director Han.

He didn't know what medicine was sold in Director Han's gourd, so he had to shut up when he couldn't figure it out.

"Don't be nervous." Director Han smiled when he saw that the young salesman was sweating, and handed him a tissue, "Take it as a friend chatting."

The young salesman took the tissue in a daze, not daring to make any unnecessary movements.

Be friends with Han Chu?This statement itself is not reliable.

And no matter how slow he was, he could tell that something was wrong, Director Han made it clear that there was a knife behind his smile.

Although he is young, he is not mentally handicapped to this extent.He is a little white rabbit, and Han Chu is a big bad wolf, so he still has a basic positioning.

"What would you like to eat?"

"Everything is fine, nothing special." The young salesman could only follow Han Chu's words.

"Have you ever eaten Sichuan hot pot?" Han Chu asked.

"Hmm." The young salesman nodded.

"When I was young, I went to Huaxi for advanced studies. When I first went there, I didn't eat spicy food, and I didn't have any expectations about it. I have a classmate in Huaxi, and the first meal I received was at a small restaurant called Zhaoxia Restaurant on the tree-lined street. Boiled pork slices eaten in a fly restaurant."

The young salesman was really stunned this time.

Director Han's tone of speech to him was definitely not condescending, but rather like a chat between friends, gentle and casual.

"It's really spicy. It's mainly numb, but it's also enjoyable. The rice is served in buckets and it's hard to eat, but I haven't forgotten the taste of heavy oil, heavy salt and heavy spicy."

"Well, I also like to eat Sichuan hot pot." The young salesman applauded apprehensively.

"How about after eating?" Director Han asked the young salesman with a smile.

After eating?

The young salesman turned his brain's CPU to the maximum and ran it quickly, looking for the true meaning of Director Han's words.

"I still want to eat after eating." The young salesman could only reply dryly.

He didn't have enough social experience, so he couldn't figure out the hidden meaning of a big bad wolf like Director Han.

Zhou Congwen smiled slightly, "After eating when I first went, must I have diarrhea the next morning?"

"Hahaha." Director Han clapped his hands and smiled, "Yes, Professor Zhou is right. The anus is hot, hot and painful. If you ask me, there must be a lot of hemorrhoid operations there. If I retire in the future , go to Rongcheng to open an anorectal hospital."

The young salesman is speechless, that's it?Is Director Han driving with him?