Rebirth of the God-level Xueba

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When Yang Rui described to Professor Jiang and Academician Zhu, he was an understatement, but in fact, knowing that the use of bovine rhodopsin for the research of g-protein coupled receptors is at least three papers away from the current mainstream scientific research direction.

The first top-level paper is to sequence the adrenal receptor gene; the second is to sequence the bovine rhodopsin; the third paper is to discover the amino acid sequence of the adrenergic receptor gene and g protein-coupled receptor , With a high degree of similarity.

This whole process actually has a certain probability.

What if Kobilka did not sequence the adrenal gland receptive genes? What if no one happens to do the sequencing of cow rhodopsin? What if no one is free to compare the amino acid sequences of the two?

This is actually a layman’s problem.

These three probabilistic questions are like asking, what if no one captures the hills ahead in a heavily assembled siege? What if it doesn’t happen to destroy the enemy’s heavy artillery group? What if it’s not exactly the same time. do……

The g protein-coupled receptors are fighting a war of meat, there is not so much at all. Why, Kobilka didn't do the sequencing of the adrenal glands? Someone will do it soon.

Maybe it will be a year or two late, but not too late.

What if no one does the sequencing of cow rhodopsin? It's like asking what to do if you don't have enough preparation for three hours of artillery fire.

With so many laboratories and spending so much money, the work was in vain, and I didn’t even leave a name. To be a laboratory for adrenaline receptive genes and bovine rhodopsin is just a matter of choosing the right target. It's a result.

There are more soldiers charging, and there are always survivors. It's not that the enemy's machine gun sweeps slowly, and it's not that you have special gun hiding skills. It's that there are enough people blocking your guns and your dog's life is big enough.

Of course, Yang Rui is not going to be cannon fodder.

Therefore, he sacrificed bovine rhodopsin protein.

This is a secret that Europe and the United States have only discovered soon.

Scholars who read the literature relatively quickly have only seen it approximately.

If Yang Rui doesn't always look for it in a targeted manner, he may not be able to see this information in a year or two.

In one or two years, I have been very nervous about other scientific research projects. In terms of g-protein coupled receptors, it is almost equal to giving up completely.

This is also part of the difficulty for scholars in third world countries to do scientific research. If it is in the United States or Europe, especially in a region where a certain project is better, the fluency of information will also be much better, and there will be more exchanges between scholars between regions. , Although it will not be updated in real time, it will not be too slow.

Especially compared with laboratories in backward regions and countries, the time difference is very decisive.

If you change to another domestic laboratory, if you find that you have fallen behind the international mainstream scientific research results by two or one year, will you still participate in such a fierce scientific research competition? Most will choose to back down.

After all, funds are limited and cannot be so wasted.

Also closely related to funding is the time and timing of the paper's publication.

In terms of national and regional prejudice, European laboratories are the laboratories that can hold back the most results. There are a large number of laboratories that have been sharpened in ten years. After that, the Japanese laboratories are more capable. They originally have domestic The tendency of communication, the independence and authority of scientific researchers can be relatively guaranteed, so it is not too much trouble to hold it for three to five years or even seven or eight years.

In comparison, laboratories in the United States are not so capable. Sometimes, for funding, laboratories can't wait to publish results.

For example, the relationship between cow rhodopsin and adrenergic receptor genes, if this result is not published, it may be one or two years ahead of other laboratories-of course, it may be one or two months.

This also depends on the laboratory's requirements for results.

If the goal is only to publish s-level papers, then the relationship between the two is proper and sufficient. If the goal is achieved, it is natural to publish the paper without hesitation.

However, if the goal is a Nobel Prize achievement, it is considered a risk, and it is said that one has to wait until it is published-the benefits of more funds, a wide range of sources, and less restrictions are usually reflected in this.

In terms of reality, the publication of the relationship between bovine rhodopsin protein and adrenal receptor genes also represents a new field of research on g protein-coupled receptors.

Most of the laboratories have once again entered the same starting line.

The cruelty of scientific research competition like a meat grinder is nothing more than that. No matter how deep your previous efforts are, as long as one person has published your results earlier, everyone will have to start all over again.

However, Su Xiankai and others obviously have not yet felt the cruelty of scientific research competition, especially the cruelty of the world's top scientific research competition.

A few of them looked at the literature with a smile, and threw two flatteries to Yang Rui by the way as encouragement.

Including Xu Zhengping, the oldest, also looked at the three with an optimistic smile. He is not going to participate in this project, but it does not hinder his expectations for the project.

Only when the ion channel laboratory develops well can the team in the laboratory live well. This is something that has long been proved.

Yang Rui will not attack them even more. Let them be happy for a while before saying: "Now that the goal is clear, we will follow the direction that our predecessors have developed. The first step is to extract bovine rhodopsin protein. Who Come to do it?"

The three looked at each other, and Su Xiankai said, "I'll be a striker."

"Then leave it to you. I want a large amount of bovine rhodopsin protein, and it must be purified cleanly."

"Leave it to me." Although Su Xiankai was under pressure, he still promised. There is no guarantee of 100% of this thing, I can only say to do my best.

Yang Rui also confirmed the start of the project.

As the person in charge of the project, his instructions can be reached at this point, and then how to extract bovine rhodopsin protein needs to be considered by Su Xiankai himself.

It was like a siege war. Yang Rui wanted to capture a fortress in the front position. He didn't need to describe in detail the tactics for attacking the fortress. That was the responsibility of the frontline commander.

Su Xiankai is the current frontline commander, and he doesn't need to charge independently. The scientific research dogs in a room selected are all used to charge him. Only when it reaches the difficult point, the key point, or when the front is really unable to overcome, will Su Xiankai himself come forward.

Regarding the work of Fan Zhenlong and Wang Sisheng, Yang Rui thought a little, and said: "Now you accompany me to read the literature, and then do a few sets of repeated experiments, and choose a few kinds of g protein to purify yourself. You can use gt, gs, gi, etc. ."

Fan Zhenlong and Wang Sisheng opened their mouths, but finally nodded helplessly ~www.wuxiaspot.com~ They put their ambitions in their hearts and started with basic skills.

The ion channel laboratory of Peking University is still not a world-class laboratory. It is not only the lack of funds and equipment, but also the lack of accumulated scientific research foundation.

Fan Zhenlong and Wang Sisheng had not done work such as g protein purification before, so on this battlefield, they are equivalent to frontline commanders who have not conducted a siege war before. They spend precious money and time, and they are also helpless choice.

In fact, Yang Rui himself has not done the purification of g protein. The complexity of this work has exceeded the scope of masters or ordinary doctoral students. However, Yang Rui has now surpassed the role of frontline commander. In the position of the battle commander, Yang Rui was already experienced.

Even if it was a war of meat, Yang Rui didn't mean anything.

With a funding of US$6 million, there are three active-duty calves with great potential, and three other calves that have not been used for reserve. It is pure resources, and Yang Rui consciously has the opportunity to fight Taierzhuang.

In all **** battles, to the end, the competition is perseverance and willpower. If you want to come, the team that can see the dawn will always take advantage.